Effects of hypertension on vasorelaxation to endocannabinoids in vitro

European Journal of Pharmacology

Volumn 603, Issue 1-3, 2009, Pages 79-85

  Wheal, Amanda J ^a   Randall, Michael D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Anandamide; Cannabinoids; Hypertension; Nitric oxide synthase; Sensory nerves; SHR

Indexed keywords

ANANDAMIDE; CANNABINOID RECEPTOR; CAPSAICIN; ENDOCANNABINOID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTANOID;

ANIMAL MODEL; ARTERY PERFUSION; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; DRUG POTENCY; ENDOTHELIUM; ENZYME INHIBITION; HYPERTENSION; IN VITRO STUDY; MALE; MESENTERIC ARTERY; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SPONTANEOUSLY HYPERTENSIVE RAT; SPRAGUE DAWLEY RAT; THORACIC AORTA; VASCULAR RING; VASCULARIZATION; VASODILATATION;

ANIMALS; AORTA; ARACHIDONIC ACIDS; CAPSAICIN; CARBACHOL; ENDOCANNABINOIDS; ENDOTHELIUM; HYPERTENSION; MALE; MESENTERIC ARTERIES; NEUROTRANSMITTER AGENTS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POLYUNSATURATED ALKAMIDES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; SENSORY RECEPTOR CELLS; TRPV CATION CHANNELS; VASODILATION;

EID: 58249123663     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.11.061     Document Type: Article

References (25)

1. Bátkai S., Pacher P., Osei-Hyiaman D., Radaeva S., Liu J., Harvey-White J., Offertaler L., Mackie K., Rudd M.A., Bukoski R.D., and Kunos G. Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation 110 (2004) 1996-2002
2. Chang H.R., Lee R.P., Wu C.Y., and Chen H.I. Nitric oxide in mesenteric vascular reactivity: a comparison between rats with normotension and hypertension. Clin. Exp. Pharmacol. Physiol. 29 (2002) 275-280
3. Harris D., McCulloch A.I., Kendall D.A., and Randall M.D. Characterization of vasorelaxant responses to anandamide in the rat mesenteric arterial bed. J. Physiol. 539 (2002) 893-902
4. Herradon E., Martin M.I., and Lopez-Miranda V. Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. Br. J. Pharmacol. 152 5 (2007) 699-708
5. Ho W.S., and Randall M.D. Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. Br. J. Pharmacol. 150 (2007) 641-651
6. Le Marquer-Domagala F., and Finet M. Comparison of the nitric oxide and cyclo-oxygenase pathway in mesenteric resistance vessels of normotensive and spontaneously hypertensive rats. Br. J. Pharmacol. 121 (1997) 588-594
7. Lewis S.J., Hashmi-Hill M.P., Owen J.R., Sandock K., Robertson T.P., and Bates J.N. The vasodilator potency of the endothelium-derived relaxing factor, L-S-nitrosocysteine, is impaired in conscious spontaneously hypertensive rats. Vascul. Pharmacol. 44 (2006) 476-490
8. Li J., Kaminski N.E., and Wang D.H. Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor. Hypertension 41 (2003) 757-762
9. Limas C., Westrum B., and Limas C.J. The evolution of vascular changes in the spontaneously hypertensive rat. Am. J. Pathol. 98 (1980) 357-384
10. Luscher T.F., and Vanhoutte P.M. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension 8 (1986) 344-348
11. Marin J., Ferrer M., and Balfagon G. Role of protein kinase C in electrical-stimulation-induced neuronal nitric oxide release in mesenteric arteries from hypertensive rats. Clin. Sci. (Lond.) 99 (2000) 277-283
12. Matrougui K., Maclouf J., Levy B.I., and Henrion D. Impaired nitric oxide- and prostaglandin-mediated responses to flow in resistance arteries of hypertensive rats. Hypertension 30 (1997) 942-947
13. Mendizábal V.E., Orliac M.L., and Adler-Graschinsky E. Long-term inhibition of nitric oxide synthase potentiates effects of anandamide in the rat mesenteric bed. Eur. J. Pharmacol. 427 (2001) 251-262
14. O'Sullivan S.E., Kendall D.A., and Randall M.D. Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries. Br. J. Pharmacol. 142 (2004) 435-442
15. O'Sullivan S.E., Kendall D.A., and Randall M.D. Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta. Eur. J. Pharmacol. 507 (2005) 211-221
16. Peroni R.N., Orliac M.L., Abramoff T., Ribeiro M.L., Franchi A.M., and Adler-Graschinsky E. Participation of CGRP and prostanoids in the sex-linked differences of vascular anandamide effects in mesenteric beds of Sprague-Dawley rats. Eur. J. Pharmacol. 557 (2007) 49-57
17. Randall M.D., Thomas G.R., and Hiley C.R. Effect of destruction of the vascular endothelium upon pressure/flow relations and endothelium-dependent vasodilatation in resistance beds of spontaneously hypertensive rats. Clin. Sci. (Lond.) 80 (1991) 463-469
18. Randall M.D., Kendall D.A., and O'Sullivan S. The complexities of the cardiovascular actions of cannabinoids. Br. J. Pharmacol. 142 (2004) 20-26
19. Rapp J.P. Use and misuse of control strains for genetically hypertensive rats. Hypertension 10 (1987) 7-10
20. St Lezin E., Simonet L., Pravenec M., and Kurtz T.W. Hypertensive strains and normotensive 'control' strains. How closely are they related?. Hypertension 19 (1992) 419-424
21. Tep-Areenan P., March J.E., Kemp P.A., Randall M.D., Kendall D.A., Bennett T., and Gardiner S.M. Effects of chronic in vivo treatment with nitric oxide synthase inhibitor on vasorelaxant responses to anandamide in rat isolated arteries. Br. J. Pharmacol. 137 (2002) 55P
22. Wang Y., Kaminski N.E., and Wang D.H. VR1-mediated depressor effects during hih-salt intake: role of anandamide. Hypertension 46 (2005) 986-991
23. Wheal A.J., Bennett T., Randall M.D., and Gardiner S.M. Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats. Br. J. Pharmacol. 152 5 (2007) 717-724
24. Wheal A.J., Bennett T., Randall M.D., and Gardiner S.M. Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro. Br. J. Pharmacol. 150 (2007) 662-671
25. Zygmunt P.M., Petersson J., Andersson D.A., Chuang H., Sorgard M., Di Marzo V., Julius D., and Hogestatt E.D. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400 (1999) 452-457