Synthesis of haloperidol prodrugs and their hydrolysis by porcine liver esterase

Drug Metabolism Letters

Volumn 2, Issue 4, 2008, Pages 275-279

  Morris, Andrew P ^a,b   Brain, Keith R ^a   Heard, Charles M ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM MALAYSIA CAMPUS   (Malaysia)

Author keywords

Ester; Haloperidol; Hydrolysis; Porcine liver esterase; Prodrug; Transdermal

Indexed keywords

ESTERASE; HALOPERIDOL BUTANOATE; HALOPERIDOL DECANOATE; HALOPERIDOL OCTANOATE; HALOPERIDOL PROPANOATE; PRODRUG; UNCLASSIFIED DRUG; HALOPERIDOL; NEUROLEPTIC AGENT;

ARTICLE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HYDROPHOBICITY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SWINE; ANIMAL; CHEMISTRY; ENZYMOLOGY; HYDROLYSIS; INTRADERMAL DRUG ADMINISTRATION; LIVER; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

SUS;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIPSYCHOTIC AGENTS; ESTERASES; HALOPERIDOL; HYDROLYSIS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PRODRUGS; SWINE;

EID: 58249116337     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208786734111     Document Type: Article

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