Chapter 6 Forster Resonance Energy Transfer Measurements of Transmembrane Helix Dimerization Energetics

Methods in Enzymology

Volumn 450, Issue , 2008, Pages 107-127

  Mikhail, Merzlyakov ^a   Kalina, Hristova ^a  

^a Johns Hopkins University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILAYER MEMBRANE; DIMERIZATION; ENERGY TRANSFER; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIPID BILAYER; PRIORITY JOURNAL; REVIEW; THERMODYNAMICS; ARTICLE; CHEMISTRY;

PROTEIN;

DIMERIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIPID BILAYERS; PROTEINS; THERMODYNAMICS;

EID: 58249091559     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(08)03406-X     Document Type: Review

References (25)

1. Adair B.D., and Engelman D.M. Glycophorin A helical transmembrane domains dimerize in phospholipid bilayers-A resonance energy transfer study. Biochemistry 33 (1994) 5539-5544
2. Cho J.Y., Guo C.S., Torello M., Lunstrum G.P., Iwata T., Deng C.X., and Horton W.A. Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc. Natl Acad. Sci. USA 101 (2004) 609-614
3. Iwamoto T., Grove A., Montal M.O., Montal M., and Tomich J.M. Chemical synthesis and characterization of peptides and oligomeric proteins designed to form transmembrane. Int. J. Pept. Protein Res. 43 (1994) 597-607
4. Iwamoto T., You M., Li E., Spangler J., Tomich J.M., and Hristova K. Synthesis and initial characterization of FGFR3 transmembrane domain: Consequences of sequence modifications. Biochim. Biophys. Acta 1668 (2005) 240-247
5. Li E., and Hristova K. Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies. Biochemistry 45 (2006) 6241-6251
6. Li E., You M., and Hristova K. SDS-PAGE and FRET suggest weak interactions between FGFR3 TM domains in the absence of extracellular domains and ligands. Biochemistry 44 (2005) 352-360
7. Li E., You M., and Hristova K. FGFR3 dimer stabilization due to a single amino acid pathogenic mutation. J. Mol. Biol. 356 (2006) 600-612
8. MacKenzie K.R. Folding and stability of alpha-helical integral membrane proteins. Chem. Rev. 106 (2006) 1931-1977
9. Merzlyakov M., Li E., Casas R., and Hristova K. Spectral Forster resonance energy transfer detection of protein interactions in surface-supported bilayers. Langmuir 22 (2006) 6986-6992
10. Merzlyakov M., Li E., Gitsov I., and Hristova K. Surface-supported bilayers with transmembrane proteins: Role of the polymer cushion revisited. Langmuir 22 (2006) 10145-10151
11. Merzlyakov M., Li E., and Hristova K. Directed assembly of surface-supported bilayers with transmembrane helices. Langmuir 22 (2006) 1247-1253
12. Merzlyakov M., You M., Li E., and Hristova K. Transmembrane helix heterodimerization in lipids bilayers: Probing the energetics behind autosomal dominant growth disorders. J. Mol. Biol. 358 (2006) 1-7
13. Merzlyakov M., Chen L., and Hristova K. Studies of receptor tyrosine kinase transmembrane domain interactions: The EmEx-FRET method. J. Membrane Biol. 215 (2007) 93-103
14. Meyers G.A., Orlow S.J., Munro I.R., Przylepa K.A., and Jabs E.W. Fibroblast-growth-factor-receptor-3 (Fgfr3) transmembrane mutation in Crouzon- syndrome with acanthosis nigricans. Nat. Genet. 11 (1995) 462-464
15. Otsuki T., Nakazawa N., Taniwaki M., Yamada O., Sakaguchi H., Wada H., Yawata Y., and Ueki A. Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia. Int. J. Oncol. 12 (1998) 545-552
16. Sackmann E. Supported membranes: Scientific and practical applications. Science 271 (1996) 43-48
17. Sackmann E., and Tanaka M. Supported membranes on soft polymer cushions: Fabrication, characterization and applications. Trends Biotechnol. 18 (2000) 58-64
18. van Rhijin B., van Tilborg A., Lurkin I., Bonaventure J., de Vries A., Thiery J.P., van der Kwast T.H., Zwarthoff E., and Radvanyi F. Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders. Eur. J. Hum. Genet. 10 (2002) 819-824
19. Webster M.K., and Donoghue D.J. Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia. EMBO J. 15 (1996) 520-527
20. White S.H., and Wimley W.C. Membrane protein folding and stability: Physical principles. Annu. Rev. Biophys. Biomol. Struct. 28 (1999) 319-365
21. Wimley W.C., and White S.H. Designing transmembrane α-helices that insert spontaneously. Biochemistry 39 (2000) 4432-4442
22. Wolber P.K., and Hudson B.S. An analytic solution to the Förster energy transfer problem in two dimensions. Biophys. J. 28 (1979) 197-210
23. You M., Li E., Wimley W.C., and Hristova K. FRET in liposomes: Measurements of TM helix dimerization in the native bilayer environment. Anal. Biochem. 340 (2005) 154-164
24. You M., Li E., and Hristova K. The achondroplasia mutation does not alter the dimerization energetics of FGFR3 transmembrane domain. Biochemistry 45 (2006) 5551-5556
25. You M., Spangler J., Li E., Han X., Ghosh P., and Hristova K. Effect of pathogenic cysteine mutations on FGFR3 transmembrane domain dimerization in detergents and lipid bilayers. Biochemistry 46 (2007) 11039-11046