Infliximab therapy rescues cyclophosphamide failure in severe central nervous system sarcoidosis

Respiratory Medicine

Volumn 103, Issue 2, 2009, Pages 268-273

  Sodhi, Manica ^a   Pearson, Karla ^a   White, Eric S ^b   Culver, Daniel A ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Central nervous system; Cyclophosphamide; Infliximab; Neurosarcoidosis; Sarcoidosis; Tumor necrosis factor

Indexed keywords

CYCLOPHOSPHAMIDE; DEXAMETHASONE; INFLIXIMAB; METHOTREXATE; METHYLPREDNISOLONE SODIUM SUCCINATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BLURRED VISION; CASE REPORT; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL ASSESSMENT; CLINICAL FEATURE; DIPLOPIA; DISEASE COURSE; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG INFUSION; DRUG MEGADOSE; DRUG PULSE THERAPY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; HUMAN; MALE; NEUROIMAGING; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PARESTHESIA; PRIORITY JOURNAL; SARCOIDOSIS; THORAX RADIOGRAPHY; TREATMENT FAILURE; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; CENTRAL NERVOUS SYSTEM DISEASES; CYCLOPHOSPHAMIDE; DISEASE PROGRESSION; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PRACTICE GUIDELINES AS TOPIC; SALVAGE THERAPY; SARCOIDOSIS; TREATMENT OUTCOME;

EID: 58249087010     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2008.08.016     Document Type: Article

References (17)

1. Burns T.M. Neurosarcoidosis. Arch Neurol 60 8 (2003) 1166-1168
2. Stern B.J., Krumholz A., Johns C., Scott P., and Nissim J. Sarcoidosis and its neurological manifestations. Arch Neurol 42 9 (1985) 909-917
3. Marino M.W., Dunn A., Grail D., Inglese M., Noguchi Y., Richards E., et al. Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci U S A 94 15 (1997) 8093-8098
4. Ziegenhagen M.W., Benner U.K., Zissel G., Zabel P., Schlaak M., and Muller-Quernheim J. Sarcoidosis: TNF-alpha release from alveolar macrophages and serum level of sIL-2R are prognostic markers. Am J Respir Crit Care Med 156 5 (1997) 1586-1592
5. Scallon B.J., Moore M.A., Trinh H., Knight D.M., and Ghrayeb J. Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions. Cytokine 7 3 (1995) 251-259
6. Wong M., Ziring D., Korin Y., Desai S., Kim S., Lin J., et al. TNFalpha blockade in human diseases: mechanisms and future directions. Clin Immunol 126 2 (2008) 121-136
7. Baughman R.P., and Lower E.E. Infliximab for refractory sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 18 1 (2001) 70-74
8. Doty J.D., Mazur J.E., and Judson M.A. Treatment of sarcoidosis with infliximab. Chest 127 3 (2005) 1064-1071
9. Toth C., Martin L., Morrish W., Coutts S., and Parney I. Dramatic MRI improvement with refractory neurosarcoidosis treated with infliximab. Acta Neurol Scand 116 4 (2007) 259-262
10. Doty J.D., Mazur J.E., and Judson M.A. Treatment of corticosteroid-resistant neurosarcoidosis with a short-course cyclophosphamide regimen. Chest 124 5 (2003) 2023-2026
11. Hunninghake G.W., Costabel U., Ando M., Baughman R., Cordier J.F., du Bois R., et al. ATS/ERS/WASOG statement on sarcoidosis. American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and other Granulomatous Disorders. Sarcoidosis Vasc Diffuse Lung Dis 16 2 (1999) 149-173
12. Zajicek J.P., Scolding N.J., Foster O., Rovaris M., Evanson J., Moseley I.F., et al. Central nervous system sarcoidosis - diagnosis and management. QJM 92 2 (1999) 103-117
13. Lower E.E., Broderick J.P., Brott T.G., and Baughman R.P. Diagnosis and management of neurological sarcoidosis. Arch Intern Med 157 16 (1997) 1864-1868
14. Mohan N., Edwards E.T., Cupps T.R., Oliverio P.J., Sandberg G., Crayton H., et al. Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides. Arthritis Rheum 44 12 (2001) 2862-2869
15. Magnano M.D., Robinson W.H., and Genovese M.C. Demyelination and inhibition of tumor necrosis factor (TNF). Clin Exp Rheumatol 22 5 Suppl. 35 (2004) S134-S140
16. Baughman R.P., Drent M., Kavuru M., Judson M.A., Costabel U., du Bois R., et al. Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement. Am J Respir Crit Care Med 174 7 (2006) 795-802
17. Judson M.A., Baughman R.P., Costabel U., Flavin S., Lo K.H., Kavuru M.S., et al. Efficacy of infliximab in extrapulmonary sarcoidosis: results from a randomised trial. Eur Respir J 31 6 (2008) 1189-1196