Tracheostomy and related host-patogen interaction are associated with airway inflammation as characterized by tracheal aspirate analysis

Respiratory Medicine

Volumn 103, Issue 2, 2009, Pages 201-208

  Pignatti, Patrizia ^a,c   Balestrino, Antonella ^a   Herr, Christian ^b   Bals, Robert ^b   Moretto, Dania ^c   Corradi, Massimo ^d   Alinovi, Rossella ^d   Delmastro, Monica ^a   Vogelmeier, Claus ^b   Nava, Stefano ^a   Moscato, Gianna ^a,c   Balbi, Bruno ^a  

^a IRCCS   (Italy)

^b UNIVERSITY HOSPITAL MARBURG   (Germany)

^c ISPESL   (Italy)

^d UNIVERSITY OF PARMA   (Italy)

Author keywords

Cytokines; Defensins; Infection; Neutrophils; Tracheostomy

Indexed keywords

DEFENSIN; STEROID;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; ASPIRATION CYTOLOGY; BACTERIAL COLONIZATION; BACTERIAL INFECTION; BACTERIUM CULTURE; CELL COUNT; CELL VIABILITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; EOSINOPHIL; FEMALE; HOST PATHOGEN INTERACTION; HUMAN; INFLAMMATORY CELL; INNATE IMMUNITY; LYMPHOCYTE; MALE; NEUROLOGIC DISEASE; NEUTROPHIL; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RESPIRATORY FAILURE; RESPIRATORY TRACT INFECTION; RESPIRATORY TRACT INFLAMMATION; SPUTUM ANALYSIS; TRACHEAL ASPIRATION PROCEDURE; TRACHEOSTOMY;

ADULT; AGED; AGED, 80 AND OVER; BRONCHITIS; CELLS, CULTURED; FEMALE; HOST-PATHOGEN INTERACTIONS; HUMANS; MALE; MIDDLE AGED; PSEUDOMONAS INFECTIONS; RESPIRATORY INSUFFICIENCY; RESPIRATORY TRACT INFECTIONS; SPUTUM; TRACHEA; TRACHEOSTOMY;

EID: 58249083746     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2008.09.008     Document Type: Article

References (26)

1. Hill N.S. Neuromuscolar disease in respiratory and critical care medicine. Respir Care 51 (2006) 1065-1071
2. Kanna B., Ayman H.A., and Soni A. Early tracheostomy in intensive care trauma patient improves resource utilization: a cohort study and literature review. Crit Care 9 (2005) 414-416
3. Cox C.E., Carson S.S., Holmes G.M., Howard A., and Carey T.S. Increase in tracheostomy for prolonged mechanical ventilation in North Carolina, 1993-2002. Crit Care Med 32 (2004) 2219-2226
4. Harlid R., Andersson G., Frostell C.G., Jorbeck H.J., and Ortqvist A.B. Respiratory tract colonization and infection in patients with chronic tracheostomy. A one-year study in patients living at home. Am J Respir Crit Care Med 154 (1996) 124-129
5. Palmer L.B., Smaldone G.C., Simon S., O'Riordan T., and Morra L. Tracheal aspirates in long-term mechanically ventilated patients. Chest 108 (1995) 1326-1332
6. Djukanovic R., Sterk P., Fahy J.V., and Hargreave F.E. Standardized methodology of sputum induction and processing. Eur Respir J 20 Suppl.37 (2002) 1s-55s
7. Pignatti P., Delmastro M., Perfetti L., Bossi A., Balestrino A., Di Stefano A., et al. Is dithiothreitol affecting cells and soluble mediators during sputum processing? A modified methodology to process sputum. J Allergy Clin Immunol 110 (2002) 667-668
8. Berthoin K., Broeckaert F., Robin M., Haufroid V., De Burbure C., and Bernard A. Serum pneumoproteins and biomarkers of exposure to urban air pollution: a cross-sectional comparison of policemen and foresters. Biomarkers 9 (2004) 341-352
9. Mutti A., Alinovi R., Bergamaschi E., Biagini C., Cavazzini S., Franchini I., et al. Nephropathies and exposure to perchloroethylene in dry-cleaners. Lancet 340 (1992) 189-193
10. Bals R., Wang X., Wu Z., Freeman T., Bafna V., Zasloff M., et al. Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 102 (1998) 874-880
11. Ekekezie II, Thibeault D.W., Simon S.D., Norberg M., Merrill J.D., Ballard R.A., et al. Low levels of tissue inhibitors of metalloproteinases with a high metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio are present in tracheal aspirate fluids of infants who develop chronic lung disease. Pediatrics 113 (2004) 1709-1714
12. Adcock K.G., Martin J., Loggins J., Kruger T.E., and Baier R.J. Elevated platelet-derived growth factor-BB concentrations in premature neonates who develop chronic lung disease. BMC Pediatr 15 (2004) 4-10
13. Baier R.J., Majid A., Parupia H., Loggins J., and Kruger T.E. CC chemokine concentrations increase in respiratory distress syndrome and correlate with development of bronchopulmonary dysplesia. Pediatr Pulomunol 37 (2004) 137-148
14. Kobayashi S.D., Voyich J.M., Whitney A.R., and DeLeo F.R. Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor. J Leukoc Biol 78 (2005) 1408-1418
15. Vento G., Matassa P.G., Zecca E., Tortorolo L., Martelli M., De Carolis M.P., et al. Effect of dexamethasone on tracheobronchial aspirate fluid cytology and pulmonary mechanics in preterm infants. Pharmacology 71 (2004) 113-119
16. Ahmed Q.A., and Niederman M.S. Respiratory infection in the chronically ill patient. Ventilator-associated pneumonia and tracheobronchitis. Clin Chest Med 22 (2001) 71-85
17. Lusuardi M., Capelli A., Di Stefano A., Zaccaria S., Balbi B., and Donner C.F. Lower respiratory tract infections in chronic obstructive pulmonary disease outpatients with tracheostomy and persistent colonization by P. aeruginosa. Respir Med 97 (2003) 1205-1210
18. Levine S.A., and Niederman M.S. The impact of tracheal intubation on host defenses and risks of nosocomial pneumoniae. Clin Chest Med 12 (1991) 523-543
19. Morar P., Singh V., Makura Z., Jones A.S., Baines P.B., Selby A., et al. Oropharyngeal carriage and lower airway colonisation/infection in 45 tracheotomised children. Thorax 57 (2002) 1015-1020
20. Lusuardi M., Capelli A., Cerutti C.G., Gnemmi I., Zaccaria S., and Donner C.F. Influence of clinical history on airways bacterial colonization in subjects with chronic tracheostomy. Respir Med 94 (2000) 436-440
21. Giannoni E., Sawa T., Allen L., Wiener J., Wiener-Kronish J., and Hawgood S. Surfactant proteins A and D enhance pulmonary clearance of Pseudomonas aeruginosa. Am J Respir Cell Mol Biol 34 (2006) 704-710
22. Schaller-Bals S., Schulze A., and Bals R. Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection. Am J Respir Crit Care Med 165 (2002) 992-995
23. Sorensen O., Arnljots K., Cowland J.B., Bainton D.F., and Borregaard N. The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils. Blood 90 (1997) 2796-2803
24. Bals R., and Wilson J.M. Cathelicidins - a family of multifunctional antimicrobial peptides. Cell Mol Life Sci 60 (2003) 711-720
25. Tjabringa G.S., Ninaber D.K., Drijfhout J.W., Rabe K.F., and Hiemstra P.S. Human cathelicidin LL-37 is chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors. Int Arch Allergy Immunol 140 (2006) 103-112
26. Harder J., Meyer-Hoffert U., Teran L.M., Schwichtenberg L., Bartels J., Maune S., et al. Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respirator epithelia. Am J Respir Cell Mol Biol 22 (2000) 714-721