Effects of acute acidemia on the fetal cardiovascular defense to acute hypoxemia

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 296, Issue 1, 2009, Pages

  Thakor, A S ^a   Giussani, D A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

ACTH; Catecholamines; Cortisol; Femoral vascular resistance; Umbilical vascular conductance

Indexed keywords

CATECHOLAMINE; CORTICOTROPIN; GLUCOSE; HYDROCORTISONE; SODIUM CHLORIDE;

ACIDEMIA; ANIMAL EXPERIMENT; ARTICLE; BRADYCARDIA; CARDIOVASCULAR FUNCTION; CATECHOLAMINE BLOOD LEVEL; CATHETER; CHEMORECEPTOR REFLEX; CONCENTRATION (PARAMETERS); CONDUCTANCE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; DEFENSE MECHANISM; FETUS; FETUS HYPOXIA; GENERAL ANESTHESIA; GLUCOSE BLOOD LEVEL; HEMODYNAMICS; HORMONE RELEASE; HYDROCORTISONE BLOOD LEVEL; IN VIVO STUDY; NERVE CELL; NONHUMAN; PH; PREGNANCY; PRIORITY JOURNAL; SHEEP; UMBILICAL ARTERY; VASOCONSTRICTION;

ACIDOSIS; ACUTE DISEASE; ADRENOCORTICOTROPIC HORMONE; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; BRADYCARDIA; CARBON DIOXIDE; CATECHOLAMINES; CHEMORECEPTOR CELLS; DISEASE MODELS, ANIMAL; FEMALE; FEMORAL ARTERY; FETAL HYPOXIA; GESTATIONAL AGE; HEART RATE; HEMODYNAMICS; HYDROCORTISONE; HYDROGEN-ION CONCENTRATION; OXYGEN; PREGNANCY; REFLEX; REGIONAL BLOOD FLOW; SHEEP; TIME FACTORS; UMBILICAL ARTERIES; VASCULAR RESISTANCE;

EID: 58149522000     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90689.2008     Document Type: Article

References (53)

1. i. Brain Res 916: 50-60, 2001.
2. Akagi K, Challis JR. Threshold of hormonal and biophysical responses to acute hypoxemia in fetal sheep at different gestational ages. Can J Physiol Pharmacol 68: 549-555, 1990.
3. Apatu RS, Barnes RJ. Release of glucose from the liver of fetal and postnatal sheep by portal vein infusion of catecholamines or glucagon. J Physiol 436: 449-468, 1991.
4. Armitage P, Berry G. Further analyses of straight-line data. In: Statistical Methods in Medical Research. Oxford, UK: Blackwell, 1994.
5. Bartelds B, van Bel F, Teitel DF, Rudolph AM. Carotid, not aortic, chemoreceptors mediate the fetal cardiovascular response to acute hypoxemia in lambs. Pediatr Res 34: 51-55, 1993.
6. Bennet L, Peebles DM, Edwards AD, Rios A, Hanson MA. The cerebral hemodynamic response to asphyxia and hypoxia in the near-term fetal sheep as measured by near infrared spectroscopy. Pediatr Res 44: 951-957, 1998.
7. Boddy K, Dawes GS, Fisher R, Pinter S, Robinson JS. Foetal respiratory movements, electrocortical and cardiovascular responses to hypoxaemia and hypercapnia in sheep. J Physiol 243: 599-618, 1974.
8. Bodelsson G, Stjernquist M. Characterization of contractile adrenoceptors in human umbilical artery. Eur J Pharmacol 282: 95-101, 1995.
9. Boyle DW, Hirst K, Zerbe GO, Meschia G, Wilkening RB. Fetal hind limb oxygen consumption and blood flow during acute graded hypoxia. Pediatr Res 28: 94-100, 1990.
10. Brooks AN, Hagan DM, Howe DC. Neuroendocrine regulation of pituitary-adrenal function during fetal life. Eur J Endocrinol 135: 153-165, 1996.
11. Chrousos GP. Stressors, stress, and neuroendocrine integration of the adaptive response. Ann NY Acad Sci 851: 311-335, 1998.
12. Cudd TA, Wood CE. Thromboxane A2 receptor antagonism prevents hormonal and cardiovascular responses to mineral acid infusion. Am J Physiol Regul Integr Comp Physiol 267: R1235-R1240, 1994.
13. Cudd TA, Wood CE. Does thromboxane mediate the fetal ACTH response to acidemia? Am J Physiol Regul Integr Comp Physiol 270: R594-R598, 1996.
14. Dweck HS, Huggins W, Dorman LP, Saxon SA, Benton JW Jr, Cassady G. Developmental sequelae in infants having suffered severe perinatal asphyxia. Am J Obstet Gynecol 119: 811-815, 1974.
15. Eyzaguirre C, Abudara V. Possible role of coupling between glomus cells in carotid body chemoreception. Biol Signals 4: 263-270, 1995.
16. Faucher DJ, Laptook AR, Parker CR, Porter JC, Rosenfeld CR. Increased fetal secretion of ACTH and cortisol by arginine vasopressin. Am J Physiol Regul Integr Comp Physiol 254: R410-R416, 1988.
17. Fee SC, Malee K, Deddish R, Minogue JP, Socol ML. Severe acidosis and subsequent neurologic status. Am J Obstet Gynecol 162: 802-806, 1990.
18. Fowden AL, Forhead AJ. Effects of pituitary hormone deficiency on growth and glucose metabolism of the sheep fetus. Endocrin 148: 4812-4820, 2007.
19. Fujiwara N, Warashina A, Shimoji K. Characterization of low pH-induced catecholamine secretion in the rat adrenal medulla. J Neurochem 62: 1809-1815, 1994.
20. Gardner DS, Fletcher AJ, Bloomfield MR, Fowden AL, Giussani DA. Effects of prevailing hypoxaemia, acidaemia or hypoglycaemia upon the cardiovascular, endocrine and metabolic responses to acute hypoxaemia in the ovine fetus. J Physiol 540: 351-366, 2002.
21. Gardner DS, Giussani DA, Fowden AL. Hindlimb glucose and lactate metabolism during umbilical cord compression and acute hypoxaemia in the late-gestation ovine fetus. Am J Physiol Regul Integr Comp Physiol 284: R954-R964, 2003.
22. Giussani DA, Gardner DS, Cox DT, Fletcher AJ. Purinergic contribution to circulatory, metabolic and adrenergic responses to acute hypoxemia in fetal sheep. Am J Physiol Regul Integr Comp Physiol 280: R678-R685, 2001.
23. Giussani DA, Riquelme RA, Hanson MA, Llanos AJ. Is the rapid and intense peripheral vasoconstriction occurring during acute hypoxaemia in the llama fetus an arterial chemoreflex? Adv Exp Med Biol 360: 341-344, 1994.
24. Giussani DA, Spencer JA, Hanson MA. Fetal cardiovascular reflex responses to acute hypoxaemia. Fetal Maternal Med Rev 6: 17-37, 1994.
25. Giussani DA, Spencer JA, Moore PJ, Bennet L, Hanson MA. Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep. J Physiol 461: 431-449, 1993.
26. Hooper SB. Fetal metabolic responses to hypoxia. Reprod Fertil Dev 7: 527-538, 1995.
27. Jones CT. The development of some metabolic responses to hypoxia in the foetal sheep. J Physiol 265: 743-762, 1977.
28. Jones CT, Ritchie JW. The effects of adrenergic blockade on fetal response to hypoxia. J Dev Physiol 5: 211-222, 1983.
29. Jones CT, Ritchie JW, Walker D. The effects of hypoxia on glucose turnover in the fetal sheep. J Dev Physiol 5: 223-235, 1983.
30. Jones CT, Robinson RO. Plasma catecholamines in foetal and adult sheep. J Physiol 248: 15-33, 1975.
31. Jones CT, Roebuck MM, Walker DW, Johnston BM. The role of the adrenal medulla and peripheral sympathetic nerves in the physiological responses of the fetal sheep to hypoxia. J Dev Physiol 10: 17-36, 1988.
32. Jones CT, Wei G. Adrenal-medullary activity and cardiovascular control in the fetal sheep. In: Fetal Heart Rate Monitoring, edited by Kunzel W. Berlin: Springer-Verlag, 1985, p. 127-135.
33. Lewis AB, Sadeghi M. Acidemia potentiates the plasma catecholamine response to hypoxemia in fetal sheep. Biol Neonate 52: 285-291, 1987.
34. Matthews JN, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. Br Med J 300: 230-235, 1990.
35. McDonald TJ, Le WW, Hoffman GE. Brainstem catecholaminergic neurons activated by hypoxemia express GR and are coordinately activated with fetal sheep hypothalamic paraventricular CRH neurons. Brain Res 885: 70-78, 2000.
36. Nicolaides KH, Economides DL, Soothill PW. Blood gases, pH, and lactate in appropriate- and small-for-gestational-age fetuses. Am J Obstet Gynecol 161: 996-1001, 1989.
37. Palmer SK. Anesthesia care for obstetric patients in the United States. In: Regional Analgesia in Obstetrics - A Millennium Update, edited by Reynolds F. London: Springer, 2000, p. 3-10.
38. Radke KJ, Schneider EG, Taylor RE Jr, Kramer RE. Effect of hydrogen ion concentration on corticosteroid secretion. Am J Physiol Endocrinol Metab 250: E259-E264, 1986.
39. Rebolledo OR, Hernandez RE, Zanetta AC, Gagliardino JJ. Insulin secretion during acid-base alterations. Am J Physiol Endocrinol Metab Gastrointest Physiol 234: E426-E429, 1978.
40. Reynolds F, Seed PT. Anaesthesia for caesarean section and neonatal acid-base status: a meta-analysis. Anaesthesia 60: 636-653, 2005.
41. Rico AJ, Prieto-Lloret J, Gonzalez C, Rigual RJ. Hypoxia and acidosis increase the secretion of catecholamines in the neonatal rat adrenal medulla. An in vitro study. Am J Physiol Cell Physiol 289: C1417-C1425, 2005.
42. Robinson PM, Comline RS, Fowden AL, Silver M. Adrenal cortex of fetal lamb: changes after hypophysectomy and effects of Synacthen on cytoarchitecture and secretory activity. Q J Exp Physiol 68: 15-27, 1983.
43. Rudolph AM. Distribution and regulation of blood flow in the fetal and neonatal lamb. Circ Res 57: 811-821, 1985.
44. Ruth VJ, Raivio KO. Perinatal brain damage: predictive value of metabolic acidosis and the Apgar score. Br Med J 297: 24-27, 1988.
45. Sestoft L, Marshall MO. Hepatic lactate uptake is enhanced by low pH at low lactate concentrations in perfused rat liver. Clin Sci (Lond) 70: 19-22, 1986.
46. Slotkin TA, Seidler FJ. Adrenomedullary catecholamine release in the fetus and newborn: secretory mechanisms and their role in stress and survival. J Dev Physiol 10: 1-16, 1988.
47. Soothill PW, Ajayi RA, Campbell S, Ross EM, Nicolaides KH. Fetal oxygenation at cordocentesis, maternal smoking and childhood neurodevelopment. Eur J Obstet Gynecol Reprod Biol 59: 21-24, 1995.
48. Thakor AS, Giussani DA. Calcitonin gene-related peptide contributes to the umbilical haemodynamic defence response to acute hypoxaemia. J Physiol 563: 309-317, 2005.
49. Wood CE, Chen HG. Acidemia stimulates ACTH, vasopressin, and heart rate responses in fetal sheep. Am J Physiol Regul Integr Comp Physiol 257: R344-R349, 1989.
50. Wood CE, Cudd TA, Kane C, Engelke K. Fetal ACTH and blood pressure responses to thromboxane mimetic U-46619. Am J Physiol Regul Integr Comp Physiol 265: R858-R862, 1993.
51. Wood CE, Isa A. Intravenous acid infusion stimulates ACTH secretion in sheep. Am J Physiol Endocrinol Metab 260: E154-E161, 1991.
52. Young IR, Chan EC, Smith R, Chrousos GP, Veldhuis JD, Canny BJ. Effect of antalarmin, a novel corticotropin-releasing hormone antagonist, on the dynamic function of the preterm ovine fetal hypothalamo-pituitary-adrenal axis. Neuroendocrinology 76: 47-54, 2002.
53. Zhang L, Dyer DC. Characterization of α-adrenoceptors mediating contraction in isolated ovine umbilical vein. Eur J Pharmacol 197: 63-67, 1991.