The leptin/adiponectin ratio in mid-infancy correlates with weight gain in healthy term infants, but is unrelated to serum insulin concentrations, body mass index, or skin fold thickness

Journal of Pediatric Endocrinology and Metabolism

Volumn 21, Issue 12, 2008, Pages 1133-1138

  Diamond, Frank ^a,e   Dharamraj, Claude ^c   Luther, Stephen ^d   Eichler, Duane ^b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b JOHNS HOPKINS ALL CHILDREN S HOSPITAL   (United States)

^c Pinellas County Health Department   (United States)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

^e NONE   (United States)

Author keywords

Adiponectin; Growth; High molecular weight adiponectin; Infancy; Insulin

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; GLUCOSE; HEMOGLOBIN; INSULIN; LEPTIN;

ARM CIRCUMFERENCE; ARTICLE; BIRTH WEIGHT; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; BOTTLE FEEDING; CHILD GROWTH; FEMALE; GLUCOSE BLOOD LEVEL; HEAD CIRCUMFERENCE; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFANT; INFANT NUTRITION; INSULIN BLOOD LEVEL; MALE; MOTHER; NUTRITIONAL ASSESSMENT; PROTEIN BLOOD LEVEL; SKINFOLD THICKNESS; TRICEPS BRACHII MUSCLE; WAIST CIRCUMFERENCE; WEIGHT GAIN;

EID: 58149491967     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2008.21.12.1133     Document Type: Article

References (19)

1. Stettler N, Stallings VA, Troxel AB, Stettler N, Stallings VA, Troxel AB, Zhao J, Schinnar R, Nelson SE, Ziegler EE, Strom BL. Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula. Circulation 2005; 111: 1897-1903.
2. Inami I, Okada T, Fujita H, Makimoto M, Hosono S, Minato, M, Takahashi S, Harada K, Yamamoto T. Impact of serum adiponectin concentration on birth size and early postnatal growth. Pediatr Res 2007; 61: 604-606.
3. Ong KK, Ahmed ML, Sherriff A, Woods KA, Watts A, Golding J, Dunger DB. Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans. J Clin Endocrinol Metab 1999; 84: 1145-1148.
4. Cianfarani S, Marinez C, Maiorana A, Scirè G, Spadoni GL, Boemi S. Adiponectin levels are reduced in children born small for gestational age and are inversely related to postnatal catch-up growth. J Clin Endocrinol Metab 2004; 89: 1346-1351.
5. Diamond FB Jr, Cuthbertson D, Hanna S, Eichler D. Correlates of adiponectin and the leptin/adiponectin ratio in obese and non-obese children. J Pediatr Endocrinol Metab 2004; 17: 1069-1075.
6. Chala E, Manes C, Iliades H, Skaragkas G, Mouratidou D, Kapantais E. Insulin resistance, growth factors and cytokine levels in overweight women with breast cancer before and after chemotherapy. Hormones (Athens) 2006; 5: 137-146.
7. Dennison BA, Edmunds LS, Stratton HH, Pruzek RM. Rapid infant weight gain predicts childhood over-weight. Obesity 2006; 14: 491-499.
8. Von Kries R, Koletzko B, Sauerwald T, von Mutius E, Barnert D, Grunert V, von Voss H. Breast feeding and obesity: cross sectional study. BJM 1999; 319: 147-150.
9. Inigüez G, Soto N, Avila A, Salazar T, Ong K, Dunger D, Mericq V. Adiponectin levels in the first two years of life in a prospective cohort: relations with weight gain, leptin levels and insulin sensitivity. J Clin Endocrinol Metab 2004; 89: 5500-5503.
10. Böttner A, Kratzsch J, Müller G, Kapellen TM, Blüher S, Keller E, Blüher M, Kiess W. Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab 2004; 89: 4053-4061.
11. Nemet D, Wang P, Funahashi T, Matsuzawa Y, Tanaka S, Engelman L, Cooper DM. Adipocytokines, body composition, and fitness in children. Pediatr Res 2003; 53: 148-152.
12. Kim J-Y, Scherer PE. Adiponectin, an adipocyte-derived hepatic insulin sensitizer regulation during development. Pediatr Endocrinol Rev 2004; 1 (Suppl 3): 428-430.
13. Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem 2003; 278: 9073-9085.
14. Araki S, Dobashi K, Kubo K, Asayama K, Shirahata A. High molecular weight, rather than total, adiponectin levels better reflect metabolic abnormalities associated with childhood obesity. J Clin Endocrinol Metab 2006; 91: 5113-5116.
15. Andersen KK, Frystyk J, Wolthers OD, Heuck C, Flyvbjerg A. Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children. J Clin Endocrinol Metab 2007; 92: 1857-1862.
16. Caminos JE, Nogueiras R, Gallego, R, Bravo S, Tovar S, Garcia-Caballero T, Casanueva FF, Diéguez C. Expression and regulation of adiponectin and receptor in human and rat placenta. J Clin Endocrinol Metab 2005; 90: 4276-4286.
17. Kadowaki K, Waguri M, Nakanishi I, Miyashita Y, Nakayama M, Suehara N, Funahashi T, Shimomura I, Fujita T. Adiponectin concentration in umbilical cord serum is positively associated with the weight ratio of fetus to placenta. J Clin Endocrinol Metab 2006; 91: 5090-5094.
18. Corbetta S, Bulfamante G, Cortelazzi D, Barresi V, Cetin I, Mantovani G, Bondioni S, Beck-Peccoz P, Spada A. Adiponectin expression in human fetal tissues during mid- and late gestations. J Clin Endocrinol Metab 2005; 90: 2397-2402.
19. Sivan E, Mazaki-Tovi S, Pariente C, Efraty Y, Schiff E, Hemi R, Kanety H. Adiponectin in human cord blood: relation to fetal birth weight and gender. J Clin Endocrinol Metab 2003; 88: 5656-5660.