Infection, Inflammation, and the Downward Spiral of Cystic Fibrosis Lung Disease

Journal of Pediatrics

Volumn 154, Issue 2, 2009, Pages 162-163

  Moss, Richard B ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT;

ANTIMICROBIAL THERAPY; CYSTIC FIBROSIS; DISEASE COURSE; EDITORIAL; HUMAN; INFLAMMATION; PATHOGENESIS; PRIORITY JOURNAL;

BRONCHOALVEOLAR LAVAGE FLUID; CHILD; CYSTIC FIBROSIS; HUMANS; INFLAMMATION; LUNG; OROPHARYNX; PREDICTIVE VALUE OF TESTS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 58149486670     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2008.09.042     Document Type: Editorial

References (18)

1. Knowles M.R., and Boucher R.C. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 109 (2002) 571-577
2. Worlitzsch D., Tarran R., Ulrich M., Schwab U., Cekici A., Meyer K.C., et al. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest 109 (2002) 317-325
3. Boucher R.C. Evidence for airway surface dehydration as the initiating event in CF airway disease. J Intern Med 261 (2007) 5-16
4. Rao S., and Grigg J. New insights into pulmonary inflammation in cystic fibrosis. Arch Dis Child 91 (2006) 786-788
5. Machen T.E. Innate immune response in CF airway epithelia: hyperinflammatory?. Am J Physiol Cell Physiol 291 (2006) C218-C230
6. Elizur A., Cannon C.L., and Ferkol T.W. Airway inflammation in cystic fibrosis. Chest 133 (2008) 489-495
7. Nichols D., Chmiel J., and Berger M. Chronic inflammation in the cystic fibrosis lung: alterations in inter- and intracellular signaling. Clinic Rev Allerg Immunol 34 (2008) 146-162
8. Jacquot J., Tabary O., and Clement A. Hyperinflammation in airways of cystic fibrosis patients: what's new?. Expert Rev Mol Diagn 8 (2008) 359-363
9. Sagel S.D., Gibson R.L., Emerson J., McNamara S., Burns J.L., Wagener J.S., et al. Impact of Pseudomonas and Staphylococcal infection on inflammation and clinical status in young children with cystic fibrosis. J Pediatr 154 (2009) 183-188
10. Rosenfeld M., Emerson J., Accurso F., Armstrong D., Castile R., Grimwood K., et al. Diagnostic accuracy of oropharyngeal cultures in infants and young children with cystic fibrosis. Pediatr Pulmonol 28 (1999) 321-328
11. Treggiari M.M., Rosenfeld M., Retsch-Bogart G., Gibson R., and Ramsey B. Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis. Pediatr Pulmonol 42 (2007) 751-756
12. Stone A., and Saiman L. Update on the epidemiology and management of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, in patients with cystic fibrosis. Curr Opin Pulm Med 13 (2007) 515-521
13. Steinkamp G., Wiedemann B., Rietschel E., Krahl A., Gielen J., Bärmeier H., et al. Prospective evaluation of emerging bacteria in cystic fibrosis. J Cyst Fibros 4 (2005) 41-48
14. Tunney M.M., Field T.R., Moriarty T.F., Patrick S., Doering G., Muhlebach M.S., et al. Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis. Am J Respir Crit Care Med 177 (2008) 995-1001
15. Harris J.K., De Groote M.A., Sagel S.D., Zemanick E.T., Kapsner R., Penvari C., et al. Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis. Proc Natl Acad Sci USA 104 (2007) 20529-20533
16. Bittar F., Richet H., Dubus J.C., Reynaud-Gaubert M., Stremler N., Sarles J., Raoult D., and Rolain J.M. Molecular detection of multiple emerging pathogens in sputa from cystic fibrosis patients. PLoS ONE 3 (2008) e2908
17. Davis S.D., Fordham L.A., Brody A.S., Noah T.L., Retsch-Bogart G.Z., Qaqish B.F., et al. Computed tomography reflects lower airway inflammation and tracks changes in early cystic fibrosis. Am J Respir Crit Care Med 175 (2007) 943-950
18. Syhre M., Scotter J.M., and Chambers S.T. Investigation into the production of 2-Pentylfuran by Aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples. Med Mycol 46 (2008) 209-215