Physical and psychosexual pubertal development: Physiology and pathophysiology of puberty with lessons learned from those with disorders of sex development

Pediatric Endocrinology Reviews

Volumn 6, Issue 2, 2008, Pages 248-256

  Lee, Peter A ^a,b   Houk, Christopher P ^c  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Adolescence; Precocious puberty; Puberty; Sexual behavior

Indexed keywords

ANDROGEN; ANTIANDROGEN; AROMATASE INHIBITOR; CHORIONIC GONADOTROPIN; G PROTEIN COUPLED RECEPTOR 54; GONADORELIN; GONADORELIN DERIVATIVE; GONADORELIN RECEPTOR; GONADOTROPIN; GROWTH FACTOR RECEPTOR; KETOCONAZOLE; LUTEINIZING HORMONE RECEPTOR; NEUROTRANSMITTER; PARATHYROID HORMONE; SEX HORMONE; SPIRONOLACTONE;

ALBRIGHT SYNDROME; BEHAVIOR CHANGE; GENE EXPRESSION REGULATION; GENE MUTATION; GONADORELIN RELEASE; HUMAN; LEYDIG CELL TUMOR; MALE GENITAL SYSTEM DISEASE; PATHOPHYSIOLOGY; PHYSICAL DEVELOPMENT; PRECOCIOUS PUBERTY; PSYCHOSEXUAL DEVELOPMENT; PSYCHOSEXUAL DISORDER; PSYCHOSOCIAL DISORDER; PUBERTY DISORDERS; REVIEW; SEXUAL BEHAVIOR; SEXUAL DEVELOPMENT; SEXUAL MATURITY; SOMATIC MUTATION;

BRAIN; GONADAL STEROID HORMONES; HUMANS; MODELS, BIOLOGICAL; PSYCHOSEXUAL DEVELOPMENT; PUBERTY; PUBERTY, PRECOCIOUS; SEX DIFFERENTIATION; SEX DIFFERENTIATION DISORDERS; SEXUAL MATURATION;

EID: 58149481382     PISSN: 15654753     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (54)

1. Grumbach MM, Auchus RJ. Estrogen: consequences and implications of human mutations in synthesis and action. J Clin Endocrinol Metab 1999;84:4677-4694
2. Wilson JD. Androgens, androgen receptors, and mate gender role behavior. Horm Behav 2001;40:358-366
3. Arnold AP, Burgoyne PS. Are XX and XY brain cells intrinsically different? Trends Enclocrinot Metab 2004;15:6-11
4. Bocklandt S, Vilain E. Sex differences in brain behavior: hormone versus gene. Adv Genet 2007;59:245-266
5. de Courten-Myers G M. The human cerebral cortex: gender differences in structure and function. J Neuropathol Exp Neurol 1999;58:217-226
6. Rabinowicz T, Dean DE, Petetot JM, de Courten-Myers GM. Gender differences in the human cerebral cortex: more neurons in males; more processes in females. J Child Neurol 1999;14:98-107
7. Dewing P, Shi T, Horvath S, Vilain E. Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. Molecular Brain Research 2003;118:82-90
8. Galatzer A, Beth-Halachmi N, Kauli R, Laron Z. Intellectual function of girls with precocious puberty. Pediatrics 1984;74;246-249
9. Seminara S, Messager S, Chatzidaki E, Thresher RR, Acierno Jr J S, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF Jr, Aparicio SA, Colledge WH. The GPR54 gene as a regulator of puberty. N Engt J Med 2003;349:1614-1627
10. Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, Colledge WH, Caraty A, Aparicio SA. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc. Natl Acad. Sci. USA 2005;102:1761-1766
11. Plant TM, Ramaswamy S, Dipietro MJ. Repetitive activation of hypothalamic GPR54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of GnRH discharges. Endocrinology 2006;147:1007-1013
12. Semple RK, Achermann JC, Ellery J, Farooqi IS, Karet FE, Stanhope RG, O'rahilly S, Aparicio SA. Two novel missense mutations in a g protein - coupled receptor 54 in a patient with hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2005;90:1849-1855
13. Teles MG, Bianco SD, Brito VN, Trarbach EB, Kuohung W, Xu S, Seminara SD, Mendonca BB, Kaiser UB, LaTronico AC. A GPF54-activating mutation in a patient with central precocious puberty. N Engl J Med 2008;358:709-715
14. Dode C, Hardelin JP. Kallmann syndrome: fibroblast growth factor signaling insufficiency? J Mol Med 2004;82:725-734
15. Shenker A, Laue L, Kosugi S, Merendion Jr.J J, Minegish T, Cutler Jr GB. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature 1993;365:652-654
16. Shenker A, Weinstein LS, Moran A, Pescovitz OH, Charest NJ, Boney CM, Van Wyk JJ, Merinom J, Feuillan PP, Speigel AM. Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein GS. J Pediatr 1993;123:509-518
17. Latronico AC, Lins TS, Brito VN, Arnhold IJ, Mendonca BB. The effect of distinct activating mutations of the luteinizing hormone receptor gene on the pituitary-gonadal axis in both sexes. Clin Endocrinot (Oxf) 2000;53:609-613
18. Leschek EW, Chan WY, Diamond DA. Nodular Leydig cell hyperplasia in a boy with familial male-limited precocious puberty. J Pediatr 2001;138:949-951
19. Bertelloni S, Baroncelli G I, Lala R, Cappa M, Matarazzo P, De Sanctis C, Saggese G. Long-term outcome of male-limited gonadotropin independent precocious puberty. Horm Res 1997;48:235-239
20. Soriano-Guillen L, Lahlou N, Chauvet G, Roger M, Chaussain JL, Carel JC. Adult height after ketoconazole treatment in patients with familial male-limited precocious puberty. J Clin Endocrinol Metab 2005;90:147-151
21. Eugster EA. Aromatase inhibitors in precocious puberty: rationale and experience to date. Treat Endocrinol 2004;3:141-151
22. Reiter EO, Norjavaara E. Testotoxicosis: current viewpoint. Pediatr Endocrinol Rev 2005;3:77-86
23. d'Alva CB, Brito VN, Pathares; HM, Carvalho FM, Arnhold IJ, Mendonca BB, Latronico AC. A single somatic activating Asp578His mutation of the luteinizing hormone receptor causes Leydig cell tumour in boys with gonadotropin-independent precocious puberty. Clin Endocrinol. 2006;65:408-410
24. Starzyk J, Starzyk B, Bartnik-Mikuta A, Urbanowicz W, Dziatkowick H. Gonadotropin releasing hormone-independent precocious puberty in a 5 year-oid girl with suprasellar germ cell tumor secreting beta-hCG and alpha-fetoprotein. J Pediatr Endocrinol Metab 2001;14:789-796
25. de Monleon JV, Simonin G, Pincemaille O, Buttin C, Sartes J. Precocious puberty secondary to an intramedullary germinoma. Arch Pediatr 1999;6:46-49
26. Sisk CL, Foster DL. The neural basis of puberty and adolescence. Nature Neuroscience 2004;7:1040-1047
27. Finkelstein J W, Susman EJ, Chinchilli VM, D'Arcangeto MR, Kunselman SJ, Schwab J, Demers LM, Liben LS, Kulin HE. Effects of estrogen or testosterone on self-reported sexual response and behaviors in hypogonadal adolescents. J Clin Endocrinol Metab 1998;83:2281-2228
28. Hines M, Brook C, Conway GS. Androgen and psychosexual development: core gender identity, sexual orientation and recalled childhood gender role behavior in women and men with congenital adrenal hyperplasia (CAH). J Sex Res 2004;41:75-81
29. Berenbaum SA, Bailey JM. Effects on gender identity of prenatal androgens and genital appearance: evidence from girls with congenital adrenal hyperplasia. J Clin Endocrinol Metab 2003;88:1102-1106
30. Michael RT, Gagnon JH, Laumann EO, Kolata G. Sex in America: A Definitive Survey. Boston: Little Brown 1994 Chapter 2, pp 15
31. Sun SS, Schubert CM, Chumlea WC, Roche AF, Kulin HE, Lee PA, Himes JH, Ryan AS. National estimates of the timing of sexual maturation and racial differences in US children. Pediatrics 2002;110:911-919
32. Grunbaum JA, Kann L, Kinchen SA, Williams B, Ross JG, Lowry R, Kolbe L. Youth risk behavior surveillance, United States, 2001. MMWR CDC Surveillance Summaries 2002;51:1-62
33. Cuffee JJ, Hallfors DD, Walter MW. Racial and gender differences in adolescent sexual attitudes and longitudinal associations with coital debut. J Adolesc Health 2007;41:19-26
34. Gates GJ, Sonenstein FL. Heterosexual genital sexual activity in adolescent males: 1988 and 1995. Fam Plann Perspect 2000;32:295-297
35. Martino SC, Collins RL, Elliott MN, Strachman A, Kanouse DE, Berry SH. Exposure to degrading versus nondegrading music lyrics and sexual behavior in youth. Pediatrics 2006; 118:e430-e441
36. Collins RL, Elliott MN, Berry SH, Kanouse DE, Kunkel D, Hunter SB, Miu A. Watching sex on television predicts adolescent initiation of sexual behavior. Pediatrics 2004;114:e280-e289
37. Fortenberry JD, Temkit M, Tu W, Graham CA, Katz BP, Orr DP. Daily mood, partner support, sexual interest, and sexual activity in adolescent women. Health Psychol 2005;24:252-257
38. Ott MA, Pfeiffer EJ, Fortenberry JD. Perceptions of sexual abstinence in high-risk early and middle adolescents. J Adolesc Health 2006;39:192-198
39. Susman EJ, Finkelstein JW, Chinchilli VM, Schwab J, Liben LS, D'Arcangeto MR, Meinke J, Demers LM, Lookingbill G, Kulin HE. The effect of sex hormone replacement therapy on behavior problems and moods in adolescents with delayed puberty. J Pediatr 1998;133:521-525
40. Meyer-Bahlburg HF, Dolezal C, Baker SW, Carlson AD, Obeid JS, New MI. Prenatal androgenization affects gender-related behavior but not gender identity in 5-12-year old girls with congenital adrenal hyperplasia. Arch Sex Behav 2004;33:97-104
41. Wisniewski AB, Migeon CJ, Malouf MA, Geargart JP. Psychosexual outcome in women affected by congenital adrenal hyperplasia due to 21 -hydroxylase deficiency. J Urol 2004;171:2497-2501
42. Meyer-Bahlberg HF, Dolezal C, Baker SW, Ehrhardt AA, New MI Gender development in women with congenital adrenal hyperplasia as a function of disorder severity. Arch Sex Behav 2006;35:667-684
43. Meyer-Bahlberg HF, Gruen RS, New MI, Bell JJ, Morishima A, Shimshi M, Bueno Y, Vargas I, Baker SW. Gender change from female to male in classical congenital adrenal hyperplasia. Horm. Behav 1996;30:319-332
44. Jorge JC, Echeverri C, Medina Y, Acevedo P. Male gender identity in an XX individual with congenital adrenal hyperplasia. J Sex Med 2008;5:122-131
45. Long DN, Wisniewski AB, Migeon CJ. Gender role across development in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Pediatr Endocrinol Metab 2004;17:1367-1373
46. Malouf MA, Migeon CJ, Carson KA, Petrucci L, Wisniewski AB. Cognitive outcome in adult women affected by congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Horm Res 2006;65:142-150
47. Dittmann RW, Kappes ME, Kappes MH. Sexual behavior in adolescent and adult females with congenital adrenal hyperptasia. Psychoneuroendocrinology 1992;17:153-170
48. Zucker KJ, Bradley SJ, Oliver G, Blake J, Fleming S, Hood J. Psychosexual development of women with congenital adrenal hyperplasia. Horm Behav 1996;30:300-314
49. Meyer-Bahlberg HF. Gender and sexuality in classic congenital adrenal hyperplasia. Endocrinol Metab Clin North AM 2001;30:155-171
50. Schober JM, Meyer-Bahlburg HF, Ransley PG. Self-assessment of genital anatomy, sexual sensistivity and function in women: implications for genitoplasty. BJU Int 2004;94:589-594
51. Crouch NS, Minto CL, Laio LM, Woodhouse CR, Creighton SM. Genital sensation after feminizing genitoplasty from congenital adrenal hyperplasia: a pilot study. BJU Int 2004;93:135-138
52. Ebert A, Scheuering S, Schott G, Roesch WH. Psychosocial and psychosexual development in childhood and adolescence within the exstrophy-epispadias complex. J Urol 2005;174:1094-1098
53. Reiner WG, Gearhart J P, Jeffs R. Psychosexual dysfunction in males with genital anomalies: late adolescence, Tanner stages IV to VI. J Am Acad Child Adolesc Psychiatry 1999;38:865-872
54. Stikkelbroeck MM, Beerendonk CC, Willemsen WN, Schreuders-Bais CA, Feitz WF, Rieu PN, Hermus AR, Otten BJ. The long term outcome of feminizing genital surgery for congential adrenal hyperplasia: anatomical, functional and cosmetic outcomes, psychosexual development, and satisfaction in adult female patients. J Pediatr Adolesc Gynecol 2003;16:289-296