Male gender identity in an XX individual with congenital adrenal hyperplasia

Journal of Sexual Medicine

Volumn 5, Issue 1, 2008, Pages 122-131

  Jorge, Juan Carlos ^a,b   Echeverri, Carolina ^a   Medina, Yailis ^a   Acevedo, Pedro ^a  

^a UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^b University of Puerto Rico Medical Sciences Campus   (Puerto Rico)

Author keywords

Congenital adrenal hyperplasia; Gender identity; Intersexuality

Indexed keywords

17 HYDROXYCORTICOSTEROID; 17 OXOSTEROID; CORTISONE ACETATE; DEXAMETHASONE; HYDROCORTISONE; PREDNISONE;

ADRENAL SUPPRESSION; ADULT; ANAMNESIS; ARTICLE; CASE REPORT; CONGENITAL ADRENAL HYPERPLASIA; DISEASE ASSOCIATION; GENDER IDENTITY; HETEROSEXUAL MALE; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT COMPLIANCE; PRIORITY JOURNAL; PSEUDOHERMAPHRODITISM; SEMI STRUCTURED INTERVIEW; STANDARDIZATION; URINALYSIS; UTERUS MALFORMATION; VIRILIZATION; XX MALE;

EID: 37549053605     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2007.00558.x     Document Type: Article

References (61)

1. Fausto-Sterling A. Sexing the body: Gender politics and the construction of sexuality. New York, NY: Basic Books; 2000.
2. Fausto-Sterling A. The five sexes, revisited. Sciences 2000; 40: 18-23.
3. Dreger AD. Hermaphrodites and the medical invention of sex. Cambridge, MA: Harvard University Press; 1998.
4. Blackless M, Charuvastra A, Derryck A, Fausto-Sterling A, Lauzanne K, Lee E. How sexually dimorphic are we? Review and synthesis. Amer J Human Biol 2000; 12: 151-66.
5. Sax L. How common is intersex? A response to Anne Fausto-Sterling. J Sex Res 2002; 39: 174-8.
6. Diamond M. Sex, gender, and identity over the years: A changing perspective. Child Adolesc Psychiatr Clin N Am 2004; 13: 591-607.
7. Lee PA, Witchel SF. Genital surgery among females with congenital adrenal hyperplasia: Changes over the past five decades. J Pediatr Endocrinol Metab 2002; 15: 1473-7.
8. Daaboul J, Frader J. Ethics and the management of the patient with intersex: A middle way. J Pediatr Endocrinol Metab 2001; 14: 1575-83.
9. Nelson CP, Gearhart JP. Current views on evaluation, management, and gender assignment of the intersex infant. Nature Clin Pract Urol 2004; 1: 38-43.
10. Thyen U, Ritcher-Applet H, Wiesemann C, Martin-Holterhus P, Hiort O. Deciding on gender in children with intersex conditions: Considerations and controversies. Treat Endocrinol 2005; 4: 1-8.
11. Hampson JG, Money J, Hampson JL. Hermaphroditism: Recommendations concerning case management. J Clin Endocrinol Metab 1956; 16: 547-56.
12. Money J, Hampson JG, Hampson JL. Imprinting and the establishment of gender role. AMA Arch Neurol Psychiatry 1957; 77: 333-6.
13. Diamond M. Pediatric management of ambiguous and traumatized genitalia. J Urol 1999; 162: 1021-8.
14. Diamond M, Sigmundson HK. Sex assignment at birth: Long-term review and clinical implications. Arch Pediatr Adolesc Med 1997; 151: 298-304.
15. Wilson BE, Reiner WG. Management of intersex: A shifting paradigm. J Clin Ethics 1998; 9: 360-9.
16. Lee PA. A perspective on the approach to the intersex child born with genital ambiguity. J Pediatr Endocrinol Metab 2004; 17: 133-40.
17. American Academy of Pediatrics, Committee on Genetics, Section on Endocrinology, Section on Urology. Evaluation of the newborn with developmental anomalies of the external genitalia. Pediatrics 2000; 106: 138-42.
18. Chase C. Letter to the editor. Arch Sex Behav 1999; 28: 103-5.
19. Haas K. Who will make room for the intersexed? Am J Law Med 2004; 30: 41-68.
20. Martin PL. Moving toward an international standard in informed consent: the impact of intersexuality and the internet on the standard of care. Duke J Gend Law Policy 2002; 9: 135-69.
21. Frimberger D, Gearhart JP. Ambiguous genitalia and intersex. Urol Int 2005; 75: 291-7.
22. White PC, Speiser PW. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Endocr Rev 2000; 21: 245-91.
23. Grumbach MM, Hughes IA, Conte FA. Disorders of sex differentiation. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, eds. Williams textbook of endocrinology. Philadelphia: Saunders 10th edition. 2003; 22: 842-1002.
24. Meyer-Bahlburg HFL, Dolezal C, Baker SW, Carlson AD, Obeid JS, New MI. Prenatal androgenization affects gender-related behavior but not gender identity in 5-12 year-old girls with congenital adrenal hyperplasia. Arch Sex Behav 2004; 33: 97-104.
25. Meyer-Bahlburg HFL. Gender and sexuality in classic congenital adrenal hyperplasia. Endocrinol Metab Clin 2001; 30: 155-71.
26. Ruble DN, Martin CL. Gender development. In: Damon W, Eisenberg N, eds. Handbook of child psychology. 5th edition, Vol 3. Social, emotional, and personality development. New York, NY: John Wiley & Sons; 1998: 933-1016.
27. Hines M, Golombok S, Rust J, Johnston K, Golding J. Testosterone during pregnancy and gender role behavior of preschool children: A longitudinal study. Child Dev 2002; 73: 1678-87.
28. Zucker K, Bradley S, Oliver G, Blake J, Fleming S, Hood J. Psychosexual development of women with congenital adrenal hyperplasia. Horm Behav 1996; 30: 300-18.
29. Long DN, Wisniewski AB, Migeon CJ. Gender role across development in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Pediatr Endocrinol Metab 2004; 17: 1367-73.
30. Prader A. Der genital befund bein pseudohermaphroditismus femeninus des kongenitalen androgenitalen síndrome. Helv Paediatr Acta 1954; 9: 231-48.
31. Bullough V. Sexual variance in society and history. New York, NY: John Wiley and Sons; 1976.
32. Fiedler L. Freaks: Myths and images of the second self. New York, NY: Simon and Schuster; 1978.
33. Kunhle U, Krahl W. The impact of culture on sex assignment and gender development in intersex patients. Perspect Biol Med 2002; 45: 85-103.
34. Boyle ME, Smith S, Liao LM. Adult genital surgery for intersex: A solution to what problem? J Health Psychol 2005; 10: 573-84.
35. Money J, Ehrhardt AA. Man & wowan, boy & girl. Baltimore, MD: John Hopkins University Press; 1972.
36. Barreto-Estrada J, Parrilla J, Jorge JC. Exposure to an anabolic steroid changes female mice sexual responses according to sex partner. J Sex Med 2007; 4: 878-85.
37. Chudakov B, Ben Zion IZ, Belmaker RH. Transdermal testosterone gel prn application for hypoactive sexual desire disorder in premenopausal women: A controlled pilot study of the effects on the Arizona Sexual Experiences Scale for females and sexual function questionnaire. J Sex Med 2007; 4: 204-8.
38. Heard-Davison A, Heiman JR, Kuffel S. Genital and subjective measurement of time course effects of an acute dose of testosterone vs. placebo in postmenopausal women. J Sex Med 2007; 4: 209-17.
39. Swaab DF, Chung WC, Krujiver FPM, Hofman MA, Ishunina TA. Sexual differentiation of the human hypothalamus. Adv Exp Med Biol 2002; 511: 75-100 (Discussion 100-5).
40. Swaab DF. Sexual differentiation of the human brain: Relevance for gender identity, transsexualism, and sexual orientation. Gynecol Endocrinol 2004; 19: 301-12.
41. Meyer-Bahlburg HFL. Intersexuality and the diagnosis of gender identity disorder. Arch Sex Behav 1994; 23: 21-40.
42. Slijper FME, Drop SLS, Molenaar JC, Muinck Keizer-Schrama SMPF. Long-term psychological evaluation of intersex children. Arch Sex Behav 1998; 27: 125-44.
43. Kolon TF, Ferrer FA, McKenna PH. Clinical and molecular analysis of XX sex reversed patients. J Urol 1998; 160: 1169-72.
44. Minto CL, Crouch NS, Conway GS, Creighton SM. XY females: Revisiting the diagnosis. BJOG 2005; 112: 1407-10.
45. Dewing P, Shi T, Horvath S, Vilain E. Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. Brain Res Mol Brain Res 2003; 118: 82-90.
46. De Jong TPVM, Boemers TML. Neonatal management of female intersex by clitorovaginoplasty. J Urol 1995; 154: 830-2.
47. Creighton S. Surgery for intersex. J R Soc Med 2001; 94: 218-20.
48. Creighton SM. Adult female outcomes of feminizing surgery for ambiguous genitalia. Pediatr Endocrinol Rev 2004; 2: 199-202.
49. Eroglu E, Tekant G, Gundogdu G, Emir H, Ercan O, Soyet Y, Danismend N. Feminizing surgical management of intersex patients. Pediatr Surg Int 2004; 20: 543-7.
50. Greenfield SP, Sadler BT, Wan J. Two-stage repair for severe hypospadias. J Urol 1994; 152: 498-501.
51. Hendren WH, Atala A. Repair of the high vagina in girls with severely masculinized anatomy from the adrenogenital syndrome. J Pediat Surg 1995; 30: 91-4.
52. Hrabovszky Z, Hutson JM. Surgical treatment of intersex abnormalities: A review. Surg 2002; 131: 92-104.
53. Lean WL, Desphande A, Hutson J, Grover SR. Cosmetic and anatomic outcomes after feminizing surgery for ambiguous genitalia. J Pediat Surg 2005; 40: 1856-60.
54. Minto CL, Liao LM, Woodhouse CRJ, Ransley PG, Creighton SM. The effect of clitoral surgery on sexual outcome in individuals who have intersex conditions with ambiguous genitalia: A cross-sectional study. Lancet 2003; 361: 1252-7.
55. Schober JM. Feminizing genitoplasty: A synopsis of issues relating to genital surgery in intersex individuals. J Pediatr Endocrinol Metab 2004; 17: 697-703.
56. Brinkmann, L. Gender assignment and medical history of individuals with different forms of intersexuality: Evaluation of medical records and the patients' perspective. J Sex Med 2007 (in press).
57. Johnson TW, Brett MA, Roberts LF, Wassersug RJ. Eunuchs in contemporary society: Characterizing men who are voluntarily castrated (Part I). J Sex Med 2007 (in press).
58. Johnson TW, Brett MA, Roberts LF, Wassersug RJ. Eunuchs in contemporary society: Expectations, consequences and adjustments to castration (Part II). J Sex Med 2007 (in press).
59. Jacobeit, J. Long-acting intramuscular testosterone undecanoate for treatment of female to male transgender individuals. J Sex Med 2007 (in press).
60. Sohn M, Bosinski HAG. Gender identity disorders: Diagnostic and surgical aspects. J Sex Med 2007 (in press).
61. Schultheiss D, Herrmann TRW, Jonas U. Early photo-illustration of a hermaphrodite by the French photographer and artist Nadar in 1860. J Sex Med 2007; 3: 355-60.