Gender-incompatible liver transplantation is not a risk factor for patient survival

Liver International

Volumn 29, Issue 2, 2009, Pages 196-202

  Lehner, Frank ^a   Becker, Thomas ^a   Klempnauer, Jürgen ^a   Borlak, Jürgen ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Gender incompatibility; Livertrans plantation; Steroid metabolism; Survival

Indexed keywords

6 ALPHA HYDROXYTESTOSTERONE; ANDROGEN; STEROID; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AGED; ANDROGEN METABOLISM; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; FEMALE; GRAFT SURVIVAL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL; LIVER DISEASE; LIVER ISCHEMIA; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; ORGAN DONOR; OUTCOME ASSESSMENT; RECIPIENT; RISK FACTOR; SEX DIFFERENCE; STEROID METABOLISM; TESTOSTERONE METABOLISM;

FEMALE; GRAFT SURVIVAL; HEPATOCYTES; HUMANS; LIVER TRANSPLANTATION; MALE; SEX FACTORS; SURVIVAL ANALYSIS; TESTOSTERONE; TREATMENT OUTCOME;

EID: 58149479841     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2008.01827.x     Document Type: Article

References (39)

1. Adam R, Mcmaster P, O'Grady JG, et al. Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry. Liver Transpl 2003; 9: 1231-43.
2. Northup PG, Pruett TL, Stukenborg GJ, Berg CL. Survival after adult liver transplantation does not correlate with transplant center case volume in the MELD era. Am J Transpl 2006; 6: 2455-62.
3. Maluf DG, Edwards EB, Kauffman HM. Utilization of extended donor criteria liver allograft: Is the elevated risk of failure independent of the model for end-stage liver disease score of the recipient? Transplantation 2006; 82: 1653-7.
4. Tector AJ, Mangus RS, Chestovich P, et al. Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival. Ann Surg 2006; 244: 439-50.
5. Northup PG, Pruett TL, Kashmer DM, Argo CK, Berg CL, Schmitt TM. Donor factors predicting recipient survival after liver retransplantation: The retransplant donor risk index. Am J Transpl 2007; 7: 1984-8.
6. De Santo LS, Marra C, De Feo M, Amarelli C, Romano G, Cotrufo M. The impact of gender on heart transplantation outcomes: A single center experience. Ital Heart J 2002; 3: 419-23.
7. Jindal RM, Ryan JJ, Sajjad I, Murthy MH, Baines LS. Kidney transplantation and gender disparity. Am J Nephrol 2005; 25: 474-83.
8. Wittnich C, Belanger MP, Askin N, Boscarino C, Wallen WJ. Lower liver transplant success in females: Gender differences in metabolic response to global ischemia. Transpl Proc 2004; 36: 1485-8.
9. Marino IR, Doyle HR, Aldrighetti L, et al. Effect of donor age and sex on the outcome of liver transplantation. Hepatology 1995; 22: 1754-62.
10. Rustgi VK, Marino G, Halpern MT, Johnson LB, Umana WO, Tolleris C. Role of gender and race mismatch and graft failure in patients undergoing liver transplantation. Liver Transpl 2002; 8: 514-8.
11. Zeier M, Dohler B, Opelz G, Ritz E. The effect of donor gender on graft survival. J Am Soc Nephrol 2002; 13: 2570-6.
12. Gaynor JJ, Moon JI, Kato T, et al. A cause-specific hazard rate analysis of prognostic factors among 877 adults who received primary orthotopic liver transplantation. Transplantation 2007; 84: 155-65.
13. Nair S, Eustace J, Thuluvath PJ. Effect of race on outcome of orthotopic liver transplantation: A cohort study. Lancet 2002; 359: 287-93.
14. Agrawal AK, Shapiro BH. Intrinsic signals in the sexually dimorphic circulating growth hormone profiles of the rat. Mol Cell Endocrinol 2001; 173: 167-81.
15. Mode A, Gustafsson JA, Jansson JO, Eden S, Isaksson O. Association between plasma level of growth hormone and sex differentiation of hepatic steroid metabolism in the rat. Endocrinology 1982; 111: 1692-7.
16. Borlak J, Hock A, Hansen T, Richter E. DNA adducts in cultures of polychlorinated biphenyl-treated human hepatocytes. Toxicol Appl Pharmacol 2003; 188: 81-91.
17. Borlak J, Thum T. Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures. Biochem Pharmacol 2001; 61: 145-53.
18. Sanfey H. Gender-specific issues in liver and kidney failure and transplantation: A review. J Women's Health (2002) 2005; 14: 617-26.
19. Brooks BK, Levy MF, Jennings LW, et al. Influence of donor and recipient gender on the outcome of liver transplantation. Transplantation 1996; 62: 1784-7.
20. Kahn D, Gavaler JS, Makowka L, Van Thiel DH. Gender of donor influences outcome after orthotopic liver transplantation in adults. Dig Dis Sci 1993; 38: 1485-8.
21. Burroughs AK, Sabin CA, Rolles K, et al. 3-month and 12-month mortality after first liver transplant in adults in Europe: Predictive models for outcome. Lancet 2006; 367: 225-32.
22. Neipp M, Bektas H, Lueck R, et al. Liver transplantation using organs from donors older than 60 years. Transpl Int 2004; 17: 416-23.
23. Dahm F, Georgiev P, Clavien PA. Small-for-size syndrome after partial liver transplantation: Definition, mechanisms of disease and clinical implications. Am J Transpl 2005; 5: 2605-10.
24. Perkins JD. Using extended criteria donor (ECD) livers: Three strikes and you're almost out. Liver Transpl 2006; 12: 1554-5.
25. Francavilla R, Hadzic N, Heaton ND, et al. Gender matching and outcome after pediatric liver transplantation. Transplantation 1998; 66: 602-5.
26. Al-Khaldi A, Oyer PE, Robbins RC. Outcome analysis of donor gender in heart transplantation. J Heart Lung Transpl 2006; 25: 461-8.
27. Sato M, Gutierrez C, Kaneda H, Liu M, Waddell TK, Keshavjee S. The effect of gender combinations on outcome in human lung transplantation: the International Society of Heart and Lung Transplantation Registry experience. J Heart Lung Transpl 2006; 25: 634-7.
28. Kwon OJ, Kwak JY. The impact of sex and age matching for long-term graft survival in living donor renal transplantation. Transpl Proc 2004; 36: 2040-2.
29. Gu Y, Dirsch O, Dahmen U, et al. Impact of donor gender on male rat recipients of small-for-size liver grafts. Liver Transpl 2005; 11: 669-78.
30. Alvaro D, Mancino MG, Onori P, et al. Estrogens and the pathophysiology of the biliary tree. World J Gastroenterol 2006; 12: 3537-45.
31. Kuebler JF, Yokoyama Y, Jarrar D, et al. Administration of progesterone after trauma and hemorrhagic shock prevents hepatocellular injury. Arch Surg 2003; 138: 727-34.
32. Reckelhoff JF, Yanes LL, Iliescu R, Fortepiani LA, Granger JP. Testosterone supplementation in aging men and women: Possible impact on cardiovascular-renal disease. Am J Physiol Renal Physiol 2005; 289: F941-8.
33. Ide T, Tsutsui H, Ohashi N, et al. Greater oxidative stress in healthy young men compared with premenopausal women. Arterioscler Thromb Vasc Biol 2002; 22: 438-42.
34. Shimizu I. Impact of oestrogens on the progression of liver disease. Liver Int 2003; 23: 63-9.
35. Pfeilschifter J, Koditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause. Endoc Rev 2002; 23: 90-119.
36. Yokoyama Y, Nimura Y, Nagino M, Bland KI, Chaudry IH. Current understanding of gender dimorphism in hepatic pathophysiology. J Surg Res 2005; 128: 147-56.
37. Federman DD. The biology of human sex differences. New Engl J Med 2006; 354: 1507-14.
38. Valle A, Guevara R, Garcia-Palmer FJ, Roca P, Oliver J. Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions. Am J Physiol Cell Physiol 2007; 293: C1302-8.
39. Wang H, Liu H, Liu RM. Gender difference in glutathione metabolism during aging in mice. Exp Gerontol 2003; 38: 507-17.