Developmental motor deficits induced by combined fetal exposure to lipopolysaccharide and early neonatal hypoxia/ischemia: A novel animal model for cerebral palsy in very premature infants

Neuroscience

Volumn 158, Issue 2, 2009, Pages 673-682

  Girard, S ^a   Kadhim, H ^b   Beaudet, N ^a   Sarret, P ^a   Sebire G ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

brain damages; cerebral palsy; hypoxia ischemia; motor behavior; neuroinflammation; prematurity

Indexed keywords

LIPOPOLYSACCHARIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CEREBRAL PALSY; CONTROLLED STUDY; DISEASE MODEL; FETUS; FRONTAL CORTEX; HISTOPATHOLOGY; MOTOR DYSFUNCTION; NEWBORN; NONHUMAN; PATHOPHYSIOLOGY; PREMATURITY; PRIORITY JOURNAL; RAT; WHITE MATTER;

EID: 58149477522     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.10.032     Document Type: Article

References (34)

1. Bell M.J., and Hallenbeck J.M. Effects of intrauterine inflammation on developing rat brain. J Neurosci Res 70 4 (2002) 570-579
2. Bracci R., and Buonocore G. Chorioamnionitis: a risk factor for fetal and neonatal morbidity. Biol Neonate 83 2 (2003) 85-96
3. Coumans A.B., Middelanis J.S., Garnier Y., Vaihinger H.M., Leib S.L., Von Duering M.U., Hasaart T.H., Jensen A., and Berger R. Intracisternal application of endotoxin enhances the susceptibility to subsequent hypoxic-ischemic brain damage in neonatal rats. Pediatr Res 53 5 (2003) 770-775
4. Dell'Anna E., Iuvone L., Calzolari S., and Geloso M.C. Effect of acetyl-L-carnitine on hyperactivity and spatial memory deficits of rats exposed to neonatal anoxia. Neurosci Lett 223 3 (1997) 201-205
5. Eklind S., Mallard C., Leverin A.L., Gilland E., Blomgren K., Mattsby-Baltzer I., and Hagberg H. Bacterial endotoxin sensitizes the immature brain to hypoxic-ischaemic injury. Eur J Neurosci 13 6 (2001) 1101-1106
6. Fan L.W., Lin S., Pang Y., Lei M., Zhang F., Rhodes P.G., and Cai Z. Hypoxia-ischemia induced neurological dysfunction and brain injury in the neonatal rat. Behav Brain Res 165 1 (2005) 80-90
7. Ferriero D.M. Neonatal brain injury. N Engl J Med 351 (2004) 1985-1995
8. Girard S., Kadhim H., Larouche A., Roy M., Gobeil F., and Sebire G. Pro-inflammatory disequilibrium of the IL-1beta/IL-1ra ratio in an experimental model of perinatal brain damages induced by lipopolysaccharide and hypoxia-ischemia. Cytokine 43 (2008) 54-62
9. Girard S., Larouche A., Kadhim H., Rola-Pleszczynski M., Gobeil F., and Sebire G. Lipopolysaccharide and hypoxia/ischemia induced IL-2 expression by microglia in neonatal brain. Neuroreport 19 (2008) 997-1002
10. Grether J.K., Nelson K.B., Emery III E.S., and Cummins S.K. Prenatal and perinatal factors and cerebral palsy in very low birth weight infants. J Pediatr 128 (1996) 407-414
11. Ikeda T., Mishima K., Aoo N., Egashira N., Iwasaki K., Fujiwara M., and Ikenoue T. Combination treatment of neonatal rats with hypoxia-ischemia and endotoxin induces long-lasting memory and learning impairment that is associated with extended cerebral damage. Am J Obstet Gynecol 191 6 (2004) 2132-2141
12. Inder T., Neil J., Kroenke C., Dieni S., Yoder B., and Rees S. Investigation of cerebral development and injury in the prematurely born primate by magnetic resonance imaging and histopathology. Dev Neurosci 27 (2005) 100-111
13. Kuban K.C., and Leviton A. Cerebral palsy. N Engl J Med 330 (1994) 188-195
14. Larouche A., Roy M., Kadhim H., Tsanaclis A.M., Fortin D., and Sebire G. Neuronal injuries induced by perinatal hypoxic-ischemic insults are potentiated by prenatal exposure to lipopolysaccharide: animal model for perinatally acquired encephalopathy. Dev Neurosci 27 (2005) 134-142
15. Liu X.H., Eun B.L., and Barks J.D. Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res 49 6 (2001) 804-811
16. Lubics A., Reglodi D., Tamás A., Kiss P., Szalai M., Szalontay L., and Lengvári I. Neurological reflexes and early motor behavior in rats subjected to neonatal hypoxic-ischemic injury. Behav Brain Res 157 1 (2005) 157-165
17. McQuillen P.S., and Ferriero D.M. Selective vulnerability in the developing central nervous system. Pediatr Neurol 30 4 (2004) 227-235
18. Nelson K.B. Can we prevent cerebral palsy?. N Engl J Med 349 18 (2003) 1765-1769
19. Nelson K.B., and Chang T. Is cerebral palsy preventable?. Curr Opin Neurol 21 2 (2008) 129-135
20. Nyakas C., Buwalda B., and Luiten P.G. Hypoxia and brain development. Prog Neurobiol 49 1 (1996) 1-51
21. Poggi S.H., Park J., Toso L., Abebe D., Roberson R., Woodard J.E., and Spong C.Y. No phenotype associated with established lipopolysaccharide model for cerebral palsy. Am J Obstet Gynecol 192 3 (2005) 727-733
22. Roberson R., Woodard J.E., Toso L., Abebe D., Poggi S.H., and Spong C.Y. Postnatal inflammatory rat model for cerebral palsy: too different from humans. Am J Obstet Gynecol 195 4 (2006) 1038-1044
23. Sheldon R.A., Chuai J., and Ferriero D.M. A rat model for hypoxic-ischemic brain damage in very premature infants. Biol Neonate 69 5 (1996) 327-341
24. Srinivasan L., Dutta R., Counsell S.J., Allsop J.M., Boardman J.P., Rutherford M.A., and Edwards A.D. Quantification of deep gray matter in preterm infants at term-equivalent age using manual volumetry of 3-tesla magnetic resonance images. Pediatrics 119 (2007) 759-765
25. Toso L., Poggi S., Park J., Einat H., Roberson R., Dunlap V., Woodard J., Abebe D., and Spong C.Y. Inflammatory-mediated model of cerebral palsy with developmental sequelae. Am J Obstet Gynecol 193 3 Pt 2 (2005) 933-941
26. Towfighi J., Housman C., Vannucci R.C., and Heitjan D.F. Effect of unilateral perinatal hypoxic-ischemic brain damage on the gross development of opposite cerebral hemisphere. Biol Neonate 65 2 (1994) 108-118
27. Vannucci R.C., Connor J.R., Mauger D.T., Palmer C., Smith M.B., Towfighi J., and Vannucci S.J. Rat model of perinatal hypoxic-ischemic brain damage. J Neurosci Res 55 (1999) 158-163
28. Volpe J. Neurology of the newborn (2001), WB Saunders Company, Philadelphia
29. Wang X., Hagberg H., Nie C., Zhu C., Ikeda T., and Mallard C. Dual role of intrauterine immune challenge on neonatal and adult brain vulnerability to hypoxia-ischemia. J Neuropathol Exp Neurol 66 6 (2007) 552-561
30. Wilson-Costello D., Friedman H., Minich N., Fanaroff A.A., and Hack M. Improved survival rates with increased neurodevelopmental disability for extremely low birth weight infants in the 1990s. Pediatrics 115 4 (2005) 997-1003
31. Winter S., Autry A., Boyle C., and Yeargin-Allsopp M. Trends in the prevalence of cerebral palsy in a population-based study. Pediatrics 110 6 (2002) 1220-1225
32. Wu Y.W., Escobar G.J., Grether J.K., Croen L.A., Greene J.D., and Newman T.B. Chorioamnionitis and cerebral palsy in term and near-term infants. JAMA 290 20 (2003) 2677-2684
33. Yager J.Y. Animal models of hypoxic-ischemic brain damage in the newborn. Semin Pediatr Neurol 11 (2004) 31-46
34. Yang L., Sameshima H., Ikeda T., and Ikenoue T. Lipopolysaccharide administration enhances hypoxic-ischemic brain damage in newborn rats. J Obstet Gynaecol Res 30 2 (2004) 142-147