Delineation of additional PSD-95 binding domains within NMDA receptor NR2 subunits reveals differences between NR2A/PSD-95 and NR2B/PSD-95 association

Neuroscience

Volumn 158, Issue 1, 2009, Pages 89-95

  Cousins, S L ^a   Kenny, A V ^a   Stephenson, F A ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

glutamate; glutamate receptor; receptor trafficking; scaffolding proteins

Indexed keywords

GUANYLATE KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; POSTSYNAPTIC DENSITY PROTEIN 95; POSTSYNAPTIC DENSITY PROTEIN 95ALPHA; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, N-METHYL-D-ASPARTATE; RODENTIA; SEQUENCE HOMOLOGY, AMINO ACID; SYNAPSES; SYNAPTIC MEMBRANES; SYNAPTIC TRANSMISSION;

EID: 58149466994     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.12.051     Document Type: Article

References (22)

1. Bassand P., Bernard A., Rafiki A., Gayet D., and Khrestchatisky M. Differential interaction of the tSXV motifs of the NR1 and NR2A receptor subunits with PSD-95 and SAP97. Eur J Neurosci 11 (1999) 2031-2043
2. Chazot P.L., Coleman S.K., Cik M., and Stephenson F.A. Molecular characterisation of NMDA receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. J Biol Chem 29 (1994) 24403-24409
3. Cik M., Chazot P.L., and Stephenson F.A. Optimal expression of cloned NMDAR1/NMDAR2A heteromeric glutamate receptors: A biochemical characterisation. Biochem J 296 (1993) 877-883
4. Cousins S.L., Papadakis M., Rutter A.R., and Stephenson F.A. Differential interaction of NMDA receptor subtypes with the PSD-95 family of MAGUK proteins. J Neurochem 104 (2008) 901-913
5. Dingledine R., Borges K., Bowie D., and Traynelis S.F. The glutamate receptor ion channels. Pharmacol Rev 51 (1999) 7-61
6. Furukawa H., Singh S.K., Mancusso R., and Gouaux E. Subunit arrangement and function in NMDA receptors. Nature 438 (2005) 185-192
7. Groc L., Heine M., Cognet L., Brickley K., Stephenson F.A., Lounis B., and Choquet D. Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors. Nat Neurosci 7 (2004) 695-696
8. Groc L., Heine M., Cousins S.L., Stephenson F.A., Lounis B., Cognet L., and Choquet D. NMDA receptor surface trafficking depends on NR2A/NR2B subunits. Proc Natl Acad Sci U S A 103 (2006) 18769-18774
9. Hawkins L.M., Chazot P.L., and Stephenson F.A. Biochemical evidence for the co-association of three NR2 subunits in recombinant N-methyl-D-aspartate receptors. J Biol Chem 274 (1999) 27211-27218
10. Kalia L.V., Pitcher G.M., Pelkey K.A., and Salter M.W. PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex. EMBO J 25 (2007) 4971-4982
11. Kim E., and Sheng M. PDZ domain proteins of synapses. Nat Rev Neurosci 5 (2004) 771-781
12. Kornau H.C., Schenker L.T., Kennedy M.B., and Seeburg P.H. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269 (1995) 1737-1740
13. Ll S.S.-C. Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction. Biochem J 390 (2005) 641-653
14. Niethammer M., Kim E., and Sheng M. Interaction between the C-terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci 16 (1996) 2157-2163
15. Papadakis M., Hawkins L.M., and Stephenson F.A. Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors. J Biol Chem 279 (2004) 14703-14712
16. Prybylowski K., Fu Z., Losi G., Hawkins L.M., Luo J., Chang K., Wenthold R.J., and Vicini S. Relationship between availability of NMDA receptor subunits and their expression at the synapse. J Neurosci 22 (2002) 8902-8910
17. Prybylowski K., Chang K., Sans N., Kan L., Vicini S., and Wenthold R.J. The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2. Neuron 47 (2005) 845-857
18. Rutter A.R., and Stephenson F.A. Co-expression of PSD-95 with NMDA receptors results in enhanced receptor expression together with a decreased sensitivity to l-glutamate. J Neurochem 75 (2000) 2501-2510
19. Shawn S.C.L. Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction. Biochem J 390 (2005) 641-653
20. 2+ channel by INAD in Drosophila photoreceptor. Neuron 16 (1996) 991-998
21. Tovar K.R., and Westbrook G.L. Mobile NMDA receptors at hippocampal synapses. Neuron 34 (2002) 255-264
22. Ulbrich M.H., and Isacoff E.Y. Subunit counting in membrane-bound proteins. Nat Methods 4 (2007) 319-321