Markers of vascular endothelial cell damage and P. falciparum malaria: Association between levels of both sE-selectin and thrombomodulin, and cytokines, hemoglobin and clinical presentation

European Cytokine Network

Volumn 19, Issue 3, 2008, Pages 123-130

  Maya, Davy W Matondo ^a,b   Mewono, Ludovic ^a,b   Nkoma, Anne Marie ^a   Issifou, Saadou ^a   Mavoungou, Elie ^a  

^a ALBERT SCHWEITZER HOSPITAL   (Gabon)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Adhesion molecules; Plasmodium falciparum

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GAMMA INTERFERON; HEMOGLOBIN; PADGEM PROTEIN; THROMBOMODULIN; TUMOR NECROSIS FACTOR ALPHA; VON WILLEBRAND FACTOR; BIOLOGICAL MARKER;

ADOLESCENT; ADULT; ARTICLE; BODY TEMPERATURE; CHILD; CONTROLLED STUDY; DISEASE MARKER; ENDOTHELIUM CELL; ENDOTHELIUM LESION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; PROTEIN BLOOD LEVEL; VASCULAR ENDOTHELIUM; VOMITING; BLOOD; INFANT; METABOLISM; PATHOLOGY; PRESCHOOL CHILD;

PLASMODIUM FALCIPARUM;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; E-SELECTIN; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMOGLOBINS; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; P-SELECTIN; THROMBOMODULIN;

EID: 58149398569     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: 10.1684/ecn.2008.0129     Document Type: Article

References (75)

1. Snow RW, Guerra CA, Noor AM, et al. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 2005; 434: 214.
2. Cohen S, Mc Gregor I, Carrington S. Gamma-globulin and acquired immunity to human malaria. Nature 1961; 192: 733.
3. Grau GE, Del Giudice G, Lambert PH. Host immune response and pathological expression in malaria: possible implications for malaria vaccines. Parasitology 1987; 94(Suppl): S123.
4. Kern P, Hemmer CJ, Van Damme J, et al. Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated Plasmodium falciparum malaria. Am J Med 1989; 87: 139.
5. Rogier C, Ly AB, Tall A, et al. Plasmodium falciparum clinical malaria in Dielmo, a holoendemic area in Senegal: no influence of acquired immunity on initial symptomatology and severity of malaria attacks. AmJTropMedHyg1999; 60: 410.
6. Williams TN, Mwangi TW, Wambua S, et al. Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases. J Infect Dis 2005; 192: 178.
7. Matondo Maya DW, Mavoungou E, et al. Distribution of IgG subclass antibodies specific for Plasmodium falciparum glutamate- rich-protein molecule in sickle cell trait children with asymptomatic infections. Exp Parasitol 2006; 112: 92.
8. MacPherson GG, Warrell MJ, White NJ, et al. Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. Am J Pathol 1985; 119: 385.
9. Pouvelle B, Buffet PA, Lepolard C, et al. Cytoadhesion of Plasmodium falciparum ring-stage-infected erythrocytes. Nat Med 2000; 6: 1264.
10. Turner GD, Morrison H, Jones M, et al. An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration. Am J Pathol 1994; 145: 1057.
11. Garcia F, Cebrian M, Dgedge M, et al. Endothelial cell activation in muscle biopsy samples is related to clinical severity in human cerebral malaria. J Infect Dis 1999; 179: 475.
12. Hollestelle MJ, Donkor C, Mantey EA, et al. von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation. Br J Haematol 2006; 133: 562.
13. Ockenhouse CF, Tegoshi T, Maeno Y, et al. Human vascular en- dothelial cell adhesion receptors for Plasmodium falciparum- infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. J Exp Med 1992; 176: 1183.
14. Berendt AR, Simmons DL, Tansey J, et al. Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmo- dium falciparum. Nature 1989; 341: 57.
15. Barnwell JW, Asch AS, Nachman RL, et al. A human 88-kD membrane glycoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected eryth- rocytes. J Clin Invest 1989; 84: 765.
16. Treutiger CJ, Heddini A, Fernandez V, et al. PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes. Nat Med 1997; 3: 1405.
17. Ho M, Schollaardt T, Niu X, et al. Characterization of Plasmo- dium falciparum-infected erythrocyte and P-selectin interaction under flow conditions. Blood 1998; 91: 4803.
18. Roberts DD, Sherwood JA, Spitalnik SL, et al. Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence. Nature 1985; 318: 64.
19. Gimbrone Jr. MA. Endothelial dysfunction, hemodynamic forces, and atherosclerosis. Thromb Haemost 1999; 82: 722.
20. Kozuka K, Kohriyama T, Nomura E, et al. Endothelial markers and adhesion molecules in acute ischemic stroke--sequential change and differences in stroke subtype. Atherosclerosis 2002; 161: 161.
21. Combes V, Taylor TE, Juhan-Vague I, et al. Circulating endothe- lial microparticles in Malawian children with severe falciparum malaria complicated with coma. JAMA 2004; 291: 2542.
22. Erdbruegger U, Haubitz M, Woywodt A. Circulating endothelial cells: a novel marker of endothelial damage. Clin Chim Acta 2006; 373: 17.
23. Hattori R, Hamilton KK, Fugate RD, et al. Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140. J Biol Chem 1989; 264: 7768.
24. Wagner DD, Olmsted JB, Marder VJ. Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. J Cell Biol 1982; 95: 355.
25. Takano S, Kimura S, Ohdama S, et al. Plasma thrombomodulin in health and diseases. Blood 1990; 76: 2024.
26. Ishii H, Uchiyama H, Kazama M. Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells. Thromb Haemost 1991; 65: 618.
27. Blann AD, McCollum CN. von Willebrand factor and soluble thrombomodulin as predictors of adverse events among subjects with peripheral or coronary atherosclerosis. Blood Coagul Fibrin- olysis 1999; 10: 375.
28. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991; 67: 1033.
29. Blann AD, Miller JP, McCollum CN. von Willebrand factor and soluble E-selectin in the prediction of cardiovascular disease progression in hyperlipidaemia. Atherosclerosis 1997; 132: 151.
30. Frijns CJ, Kappelle LJ, van Gijn J, et al. Soluble adhesion molecules reflect endothelial cell activation in ischemic stroke and in carotid atherosclerosis. Stroke 1997; 28: 2214.
31. Gearing AJ, Hemingway I, Pigott R, et al. Soluble forms ofvascu- lar adhesion molecules, E-selectin, ICAM-1, and VCAM-1: pathological significance. Ann N Y Acad Sci 1992; 667: 324.
32. Cella G, Bellotto F, Tona F, et al. Plasma markers of endothelial dysfunction in pulmonary hypertension. Chest 2001; 120: 1226.
33. Gando S, Kameue T, Matsuda N, et al. Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation. Thromb Res 2005; 116: 91.
34. Pober JS. Warner-Lambert/Parke-Davis award lecture. Cytokine- mediated activation of vascular endothelium. Physiology and pathology. Am J Pathol 1988; 133: 426.
35. May J, Lell B, Luty AJ, et al. Plasma interleukin-10:Tumor necrosis factor (TNF)-alpha ratio is associated with TNF promoter variants and predicts malarial complications. J Infect Dis 2000; 182: 1570.
36. Dodoo D, Omer FM, Todd J, et al. Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodium falciparum malaria. J Infect Dis 2002; 185: 971.
37. Lyke KE, Burges R, Cissoko Y, et al. Serum levels of the proin- flammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. Infect Immun 2004; 72: 5630.
38. Hviid L, Theander TG, Elhassan IM, et al. Increased plasma levels of soluble ICAM-1 and ELAM-1 (E-selectin) during acute Plas- modium falciparum malaria. Immunol Lett 1993; 36: 51.
39. Boehme MW, Werle E, Kommerell B, et al. Serum levels ofadhe- sion molecules and thrombomodulin as indicators of vascular injury in severe Plasmodium falciparum malaria. Clin Investig 1994; 72: 598.
40. Hemmer CJ, Bierhaus A, von Riedesel J, et al. Elevated thrombo- modulin plasma levels as a result of endothelial involvement in Plasmodium falciparum malaria. Thromb Haemost 1994; 72: 457.
41. Wenisch C, Varijanonta S, Looareesuwan S, et al. Soluble intercellular adhesion molecule-1 (ICAM-1), endothelial leukocyte adhesion molecule-1 (ELAM-1), and tumor necrosis factor receptor (55 kDa TNF-R) in patients with acute Plasmodium falciparum malaria. Clin Immunol Immunopathol 1994; 71: 344.
42. Boubou MI. Prevalence of circulating endothelial cells (CEC) and expression profile in cerebral malaria. Bull Soc Pathol Exot 2000; 93: 226.
43. Combes V, Taylor TE, Juhan-Vague I, et al. Circulating endothe- lial microparticles in malawian children with severe falciparum malaria complicated with coma. JAMA 2004; 291: 2542.
44. Hollestelle MJ, Donkor C, Mantey EA, et al. von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation. Br J Haematol 2006; 133: 562.
45. de Mast Q, Groot E, Lenting PJ, et al. Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria. J Infect Dis 2007; 196: 622.
46. Tchinda VH, Tadem AD, Tako EA, et al. Severe malaria in Cam- eroonian children: correlation between plasma levels of three soluble inducible adhesion molecules and TNF-alpha. Acta Trop 2007; 102: 20.
47. Peyron F, Caux-Menetrier C, Roux-Lombard P, et al. Soluble intercellular adhesion molecule-1 and E-selectin levels in plasma of falciparum malaria patients and their lack of correlation with levels of tumor necrosis factor alpha, interleukin 1 alpha (IL-1 alpha), and IL-10. Clin Diagn Lab Immunol 1994; 1: 741.
48. Hashimoto Y, Hirohata S, Kashiwado T, et al. Cytokine regulation of hemostatic property and IL-6 production of human endothelial cells. Inflammation 1992; 16: 613.
49. Moore KL, Esmon CT, Esmon NL. Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood 1989; 73: 159.
50. Ohnishi K. Serum levels of thrombomodulin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin in the acute phase of Plasmodium vivax malaria. AmJTropMed Hyg 1999; 60: 248.
51. Kwiatkowski D, Hill AV, Sambou I, et al. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet 1990; 336: 1201.
52. Kassa D, Petros B, Mesele T, et al. Characterization of peripheral blood lymphocyte subsets in patients with acute Plasmodium fal- ciparum and P. vivax malaria infections at Wonji Sugar Estate, Ethiopia. Clin Vaccine Immunol 2006; 13: 376.
53. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994; 84: 2068.
54. Haraldsen G, Kvale D, Lien B, et al. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human mi- crovascular endothelial cells. J Immunol 1996; 156: 2558.
55. Thornhill MH, Haskard DO. IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-gamma. J Immunol 1990; 145: 865.
56. Weiser S, Miu J, Ball HJ, et al. Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells. Cytokine 2007; 37: 84.
57. Sylla EH, Kun JF, Kremsner PG. Mosquito distribution and entomological inoculation rates in three malaria-endemic areas in Gabon. Trans R Soc Trop Med Hyg 2000; 94: 652.
58. Planche T, Krishna S, Kombila M, et al. Comparison of methods for the rapid laboratory assessment of children with malaria. Am J Trop Med Hyg 2001; 65: 599.
59. Akanmori BD, Kurtzhals JA, Goka BQ, et al. Distinct patterns of cytokine regulation in discrete clinical forms of Plasmodium fal- ciparum malaria. Eur Cytokine Netw 2000; 11: 113.
60. Yoshida M, Takano Y, Sasaoka T, et al. E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte- endothelial interactions under flow conditions. Arterioscler Thromb Vasc Biol 2003; 23: 783.
61. Testa A, Benedetto FA, Spoto B, et al. The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease. Nephrol Dial Transplant 2006; 21: 1921.
62. Liu X, Spolarics Z. Methemoglobin is a potent activator of endot- helial cells by stimulating IL-6 and IL-8 production and E-selectin membrane expression. Am J Physiol 2003; 285: C1036.
63. Wang SC, Borison HL. The vomiting center: a critical experimental analysis. Arch Neurol Psychiatry 1950; 63: 928.
64. Maruyama I, Bell CE, Majerus PW. Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblastofhuman placenta. JCell Biol 1985; 101: 363.
65. Ishii H, Salem HH, Bell CE, et al. Thrombomodulin, an endothe- lial anticoagulant protein, is absent from the human brain. Blood 1986; 67: 362.
66. McCachren SS, Diggs J, Weinberg JB, et al. Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages. Blood 1991; 78: 3128.
67. Grey ST, Hancock WW. A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes. J Immunol 1996; 156: 2256.
68. rd Ed.Philadelphia: J. B. Lippincott Company, 1994: 259.
69. Moore KL, Andreoli SP, Esmon NL, et al. Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J Clin Invest 1987; 79: 124.
70. Krishnan A, Karnad DR, Limaye U, et al. Cerebral venous and dural sinus thrombosis in severe falciparum malaria. J Infect 2004; 48: 86.
71. SenGupta SK, Naraqi S. The brain in cerebral malaria: apathologi- cal study of 24 fatal cases in Papua New Guinea. PNG Med J 1992; 35: 270.
72. Uthman's home page. Hemolytic anemias (web2.iadfw.net/ uthman/index.html.Ed) Last update 9.05.2007.
73. Essex DW, Li M. Redox control of platelet aggregation. Biochemistry 2003; 42: 129.
74. Wassmer SC, de Souza JB, Frere C, et al. TGF-beta1 released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: a new mechanism for microvascular lesion during cerebral malaria. J Immunol 2006; 176: 1180.
75. Nan B, Lin P, Lumsden AB, et al. Effects of TNF-alpha and cur- cumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Thromb Res 2005; 115: 417.