"Pulse" treatment with high-dose angiotensin blocker reverses renal arteriolar hypertrophy and regresses hypertension

Hypertension

Volumn 53, Issue 1, 2009, Pages 83-89

  Ishiguro, Kimiko ^a   Hayashi, Kaori ^a   Sasamura, Hiroyuki ^a   Sakamaki, Yusuke ^a   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Angiotensin receptor blocker; Calcium channel blocker; MMP; Regression; Renal arteriolar hypertrophy; Spontaneously hypertensive rat

Indexed keywords

ALDOSTERONE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; CANDESARTAN HEXETIL; COLLAGENASE 3; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL MALEATE; GELATINASE A; GELATINASE B; HYDRALAZINE; MATRIX METALLOPROTEINASE; NIFEDIPINE; RENIN; RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; VASODILATOR AGENT; BENZIMIDAZOLE DERIVATIVE; CANDESARTAN; ENALAPRIL; TETRAZOLE DERIVATIVE;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG MEGADOSE; GENE EXPRESSION; HISTOLOGY; HYPERTENSION; KIDNEY; MALE; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RENAL ARTERY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SODIUM RESTRICTION; SPONTANEOUSLY HYPERTENSIVE RAT; THORACIC AORTA; TREATMENT RESPONSE; WISTAR KYOTO RAT; ANIMAL; ARTERIOLE; BLOOD; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; HYPERTROPHY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ALDOSTERONE; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ARTERIOLES; BENZIMIDAZOLES; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENALAPRIL; HYDRALAZINE; HYPERTENSION; HYPERTROPHY; KIDNEY; MALE; MATRIX METALLOPROTEINASE 13; NIFEDIPINE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RENIN; TETRAZOLES; VASODILATOR AGENTS;

EID: 58149384447     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.108.122721     Document Type: Article

References (22)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005; 365:217-223.
2. Lawes CM, Vander Hoorn S, Rodgers A. Global burden of blood-pressure-related disease, 2001. Lancet. 2008;371:1513-1518.
3. Harrap SB, Van der Merwe WM, Griffin SA, Macpherson F, Lever AF. Brief angiotensin converting enzyme inhibitor treatment in young spontaneously hypertensive rats reduces blood pressure long-term. Hypertension. 1990;16:603-614.
4. Richer C, Mulder P, Fornes P, Richard V, Camilleri JP, Giudicelli JF. Hemodynamic and morphological effects of quinapril during genetic hypertension development. J Cardiovasc Pharmacol. 1991;18:631-642.
5. Nakaya H, Sasamura H, Hayashi M, Saruta T. Temporary treatment of prepubescent rats with angiotensin inhibitors suppresses the development of hypertensive nephrosclerosis. J Am Soc Nephrol. 2001;12:659-666.
6. Nakaya H, Sasamura H, Mifune M, Shimizu-Hirota R, Kuroda M, Hayashi M, Saruta T. Prepubertal treatment with angiotensin receptor blocker causes partial attenuation of hypertension and renal damage in adult Dahl salt-sensitive rats. Nephron. 2002;91:710-718.
7. Ishiguro K, Sasamura H, Sakamaki Y, Itoh H, Saruta T. Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury. Hypertens Res. 2007;30:63-75.
8. Julius S, Nesbitt SD, Egan BM, Weber MA, Michelson EL, Kaciroti N, Black HR, Grimm RH Jr, Messerli FH, Oparil S, Schork MA. Feasibility of treating prehypertension with an angiotensin-receptor blocker. N Engl J Med. 2006;354:1685-1697.
9. Smallegange C, Hale TM, Bushfield TL, Adams MA. Persistent lowering of pressure by transplanting kidneys from adult spontaneously hypertensive rats treated with brief antihypertensive therapy. Hypertension. 2004;44:89-94.
10. Skov K, Mulvany MJ. Structure of renal afferent arterioles in the pathogenesis of hypertension. Acta Physiol Scand. 2004;181:397-405.
11. Gattone VH, II, Evan AP, Willis LR, Luft FC. Renal afferent arteriole in the spontaneously hypertensive rat. Hypertension. 1983;5:8-16.
12. Ahmed AK, Haylor JL, El Nahas AM, Johnson TS. Localization of matrix metalloproteinases and their inhibitors in experimental progressive kidney scarring. Kidney Int. 2007;71:755-763.
13. Ibrahim J, Berk BC, Hughes AD. Comparison of simultaneous measurements of blood pressure by tail-cuff and carotid arterial methods in conscious spontaneously hypertensive and Wistar-Kyoto rats. Clin Exp Hypertens. 2006;28:57-72.
14. Feihl F, Liaudet L, Levy BI, Waeber B. Hypertension and microvascular remodelling. Cardiovasc Res. 2008;78:274-285.
15. Sasamura H, Shimizu-Hirota R, Saruta T. Extracellular matrix remodeling in hypertension. Curr Hypertens Rev. 2005;1:51-60.
16. Woessner JF Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 1991;5:2145-2154.
17. Mao D, Lee JK, Van Vickle SJ, Thompson RW. Expression of collagenase-3 (MMP-13) in human abdominal aortic aneurysms and vascular smooth muscle cells in culture. Biochem Biophys Res Commun. 1999; 261:904-910.
18. Kelly BA, Bond BC, Poston L. Gestational profile of matrix metalloproteinases in rat uterine artery. Mol Hum Reprod. 2003;9:351-358.
19. Zijlstra A, Aimes RT, Zhu D, Regazzoni K, Kupriyanova T, Seandel M, Deryugina EI, Quigley JP. Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3). J Biol Chem. 2004;279:27633-27645.
20. Yu VM, Lin HC, Chang WC. Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-9. Br J Nutr. 2008:1-8.
21. Guo RW, Yang LX, Li MQ, Liu B, Wang XM. Angiotensin II induces NF-kappa B activation in HUVEC via the p38MAPK pathway. Peptides. 2006;27:3269-3275.
22. Sasamura H, Nakaya H, Julius S, Takebayashi T, Sato Y, Uno H, Takeuchi M, Ishiguro K, Murakami M, Ryuzaki M, Itoh H. Short treatment with the angiotensin receptor blocker candesartan surveyed by telemedicine (STAR CAST) study: rationale and study design. Hypertens Res. 2008;31:1851-1857.