Disruption of nectin-like 1 cell adhesion molecule leads to delayed axonal myelination in the CNS

Journal of Neuroscience

Volumn 28, Issue 48, 2008, Pages 12815-12819

  Park, Jinsil ^b   Liu, Ben ^a,b   Chen, Tao ^a   Li, Hong ^b   Hu, Xuemei ^b   Gao, Jing ^a   Zhu, Ying ^b   Zhu, Qiang ^b   Qiang, Boqin ^a   Yuan, Jiangang ^a   Peng, Xiaozhong ^a   Qiu, Mengsheng ^b,c  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b University of Louisville School of Medicine   (United States)

^c TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Cell adhesion molecule; Gene targeting; Knock out; Myelination; Optic nerve; Spinal cord

Indexed keywords

CELL ADHESION MOLECULE; PROTEIN NECTIN LIKE 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE MUTATION; MOUSE; MYELINATION; NECTIN LIKE 1 GENE; NERVE GROWTH; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; SPINAL CORD;

ANIMALS; AXONS; CELL ADHESION; CELL COMMUNICATION; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; GENES, REPORTER; IMMUNOGLOBULINS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; NERVE FIBERS, MYELINATED; NEURAL CELL ADHESION MOLECULES; NEUROGENESIS; OLIGODENDROGLIA; OPTIC NERVE; SPINAL CORD; TIME FACTORS; TRANSPLANTATION CHIMERA;

EID: 58149383268     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2665-08.2008     Document Type: Article

References (22)

1. Biederer T (2006) Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules. Genomics 87:139-150.
2. Biederer T, Sara Y, Mozhayeva M, Atasoy D, Liu X, Kavalali ET, Südhof TC (2002) SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297:1525-1531.
3. Colello RJ, Pott U (1997) Signals that initiate myelination in the developing mammalian nervous system. Mol Neurobiol 15:83-100.
4. Colognato H, Ramachandrappa S, Olsen IM, ffrench-Constant C (2004) Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development. J Cell Biol 167:365-375.
5. Edgar JM, Garbern J (2004) The myelinated axon is dependent on the myelinating cell for support and maintenance: molecules involved. J Neurosci Res 76:593-598.
6. Fogel A, Akins MR, Krupp AJ, Stagi M, Stein V, Biederer T (2007) SynCAMs organize synapses through heterophilic adhesion. J Neurosci 27:12516-12530.
7. Fujita E, Urase K, Soyama A, Kouroku Y, Momoi T (2005) Distribution of RA175/TSLC1/SynCAM, a member of the immunoglobulin superfamily, in the developing nervous system. Brain Res Dev Brain Res 154-2:199-209.
8. Fukuhara H, Kuramochi M, Nobukuni T, Fukami T, Saino M, Maruyama T, Nomura S, Sekiya T, Murakami Y (2001) Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. Oncogene 20:5401-5407.
9. Kakunaga S, Ikeda W, Itoh S, Deguchi-Tawarada M, Ohtsuka T, Mizoguchi A, Takai Y (2005) Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. J Cell Sci 118:1267-1277.
10. Maurel P, Einheber S, Galinska J, Thaker P, Lam I, Rubin MB, Scherer SS, Murakami Y, Gutmann DH, Salzer JL (2007) Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination. J Cell Biol 178:861-874.
11. Miyoshi J, Takai Y (2007) Nectin and nectin-like molecules: biology and pathology. Am J Nephrol 27:590-604.
12. Mullen RJ, Buck CR, Smith AM (1992) "NeuN, a neuronal specific nuclear protein in vertebrates". Development 116:201-211.
13. Pellissier F, Gerber A, Bauer C, Ballivet M, Ossipow V (2007) The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons binds to oligodendrocytes and promotes cell adhesion. BMC Neurosci 29-8:90.
14. Perlin JR, Talbot WS (2007) Putting the glue in glia: Necls mediate Schwann cell axon adhesion. J Cell Biol 178:721-723.
15. Sara Y, Biederer T, Atasoy D, Chubykin A, Mozhayeva MG, Südhof TC, Kavalali ET (2005) Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci 25:260-270.
16. Sarnat HB, Nochlin D, Born DE (1998) Neuronal nuclear antigen (NeuN): a marker of neuronal maturation in early human fetal nervous system. Brain Dev 20:88-94.
17. Schaeren-Wiemers N, Gerfin-Moser A (1993) A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labeled cRNA probes. Histochemistry 100:431-440.
18. Spiegel I, Adamsky K, Eshed Y, Milo R, Sabanay H, Sarig-Nadir O, Horresh I, Scherer SS, Rasband MN, Peles E (2007) A central role for Necl4 (Syn-CAM4) in Schwann cell-axon interaction and myelination. Nat Neurosci 10:861-869.
19. Takai Y, Irie K, Shimizu K, Sakisaka T, Ikeda W (2003) Nectins and nectinlike molecules: roles in cell adhesion, migration, and polarization. Cancer Sci 94:655-667.
20. Urase K, Soyama A, Fujita E, Momoi T (2001) Expression of RAI75 mRNA, a new member of the immunoglobulin superfamily, in developing mouse brain. Neuroreport 12:3217-3221.
21. Wakayama T, Ohashi K, Mizuno K, Iseki S (2001) Cloning and characterization of a novel mouse immunoglobulin superfamily gene expressed in early spermatogenic cells. Mol Reprod Dev 60:158-164.
22. Zhou Y, Du G, Hu X, Yu S, Liu Y, Xu Y, Huang X, Liu J, Yin B, Fan M, Peng X, Qiang B, Yuan J (2005) Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. Biochim Biophys Acta 1669:142-154.