메뉴 건너뛰기




Volumn 89, Issue 1, 2009, Pages 71-76

L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B100; CARNITINE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXIDIZED LOW DENSITY LIPOPROTEIN; PLACEBO; THIOBARBITURIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL;

EID: 58149379405     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2008.26251     Document Type: Article
Times cited : (100)

References (54)
  • 3
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective metaanalysis of data from 90,056 participants in 14 randomised trials of statins. Cholesterol Treatment Trialists' Collaborators
    • Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective metaanalysis of data from 90,056 participants in 14 randomised trials of statins. Cholesterol Treatment Trialists' Collaborators. Lancet 2005;366:1267-78.
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3
  • 4
    • 0030799043 scopus 로고    scopus 로고
    • Low density lipoprotein oxidation and its pathobiological significance
    • Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 1997;272:20963-6.
    • (1997) J Biol Chem , vol.272 , pp. 20963-20966
    • Steinberg, D.1
  • 5
    • 0028934468 scopus 로고
    • Atherogenic dyslipidemia: Lipoprotein abnormalities and implications for therapy
    • Grundy SM. Atherogenic dyslipidemia: lipoprotein abnormalities and implications for therapy. Am J Cardiol 1995;75:45B-52B.
    • (1995) Am J Cardiol , vol.75
    • Grundy, S.M.1
  • 6
    • 0026695202 scopus 로고
    • Role of oxidized low density lipoprotein in atherogenesis
    • Parthasarathy S, Rankin SM. Role of oxidized low density lipoprotein in atherogenesis. Prog Lipid Res 1992;31:127-43.
    • (1992) Prog Lipid Res , vol.31 , pp. 127-143
    • Parthasarathy, S.1    Rankin, S.M.2
  • 7
    • 18244363912 scopus 로고    scopus 로고
    • Scavenger receptors, oxidized LDL, and atherosclerosis
    • Boullier A, Bird DA, Chang MK, et al. Scavenger receptors, oxidized LDL, and atherosclerosis. Ann N Y Acad Sci 2001;947:214-22.
    • (2001) Ann N Y Acad Sci , vol.947 , pp. 214-222
    • Boullier, A.1    Bird, D.A.2    Chang, M.K.3
  • 8
    • 0027393052 scopus 로고
    • Determination of lipid hydroperoxides in native low-density lipoprotein by a chemiluminescent flow-injection assay
    • Cominacini L, Pastorino AM, McCarthy A, et al. Determination of lipid hydroperoxides in native low-density lipoprotein by a chemiluminescent flow-injection assay. Biochim Biophys Acta 1993;1165:279-87.
    • (1993) Biochim Biophys Acta , vol.1165 , pp. 279-287
    • Cominacini, L.1    Pastorino, A.M.2    McCarthy, A.3
  • 9
    • 0029588497 scopus 로고
    • Enhanced susceptibility of low-density lipoproteins to oxidation in coronary bypass patients with progression of atheroscerosis
    • De Rijke YB, Verwey HF, Vogelezang CJ, et al. Enhanced susceptibility of low-density lipoproteins to oxidation in coronary bypass patients with progression of atheroscerosis. Clin Chim Acta 1995;243:137-49.
    • (1995) Clin Chim Acta , vol.243 , pp. 137-149
    • De Rijke, Y.B.1    Verwey, H.F.2    Vogelezang, C.J.3
  • 11
    • 0030808843 scopus 로고    scopus 로고
    • Studies on hepatic injury and antioxidant enzyme activities in rat subcellular organelles following in vivo ischemia and reperfusion
    • Gupta M, Dobashi K, Greene EL, Orak JK, Singh I. Studies on hepatic injury and antioxidant enzyme activities in rat subcellular organelles following in vivo ischemia and reperfusion. Mol Cell Biochem 1997;176:337-47.
    • (1997) Mol Cell Biochem , vol.176 , pp. 337-347
    • Gupta, M.1    Dobashi, K.2    Greene, E.L.3    Orak, J.K.4    Singh, I.5
  • 12
    • 0023687897 scopus 로고
    • Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits
    • Haberland ME, Fong D, Cheng L. Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits. Science 1988;241:215-8.
    • (1988) Science , vol.241 , pp. 215-218
    • Haberland, M.E.1    Fong, D.2    Cheng, L.3
  • 16
    • 0036929262 scopus 로고    scopus 로고
    • Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats
    • Pari L, Latha M. Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats. Singapore Med J 2002;43:617-21.
    • (2002) Singapore Med J , vol.43 , pp. 617-621
    • Pari, L.1    Latha, M.2
  • 17
    • 0025732948 scopus 로고
    • Role of oxidative stress in development of complications in diabetes
    • Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991;40:405-12.
    • (1991) Diabetes , vol.40 , pp. 405-412
    • Baynes, J.W.1
  • 18
    • 0001937655 scopus 로고
    • The potential role of oxidative stress in diabetes and ist complications: Novel implications for theory and therapy
    • Crabbe MJC, ed, London, United Kingdom: Churchill Livingstone
    • Wolff SP. The potential role of oxidative stress in diabetes and ist complications: novel implications for theory and therapy. In: Crabbe MJC, ed. Diabetic complications: scientific and clinical aspects. London, United Kingdom: Churchill Livingstone, 1987:167-221.
    • (1987) Diabetic complications: Scientific and clinical aspects , pp. 167-221
    • Wolff, S.P.1
  • 19
    • 33846871234 scopus 로고    scopus 로고
    • Cardio-cerebrovascular complications in elderly with diabetes
    • Motta M, Bennati E, Ferlito L, et al. Cardio-cerebrovascular complications in elderly with diabetes. Arch Gerontol Geriatr 2007;44:261-9.
    • (2007) Arch Gerontol Geriatr , vol.44 , pp. 261-269
    • Motta, M.1    Bennati, E.2    Ferlito, L.3
  • 20
    • 38849199866 scopus 로고    scopus 로고
    • Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
    • Bonnard C, Durand A, Peyrol S, et al. Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest 2008;118:789-800.
    • (2008) J Clin Invest , vol.118 , pp. 789-800
    • Bonnard, C.1    Durand, A.2    Peyrol, S.3
  • 21
    • 0028823795 scopus 로고
    • Biosynthesis and metabolism of carnitine
    • Carter AL, Abney TO, Lapp DF. Biosynthesis and metabolism of carnitine. J Child Neurol 1995;10(suppl 2):S3-7.
    • (1995) J Child Neurol , vol.10 , Issue.SUPPL. 2
    • Carter, A.L.1    Abney, T.O.2    Lapp, D.F.3
  • 22
    • 0023463883 scopus 로고    scopus 로고
    • Seccombe DW, James L, Hahn P, Jones E. L-Carnitine treatment in the hyperlipidemic rabbit. Metabolism 1987;36:1192-6.
    • Seccombe DW, James L, Hahn P, Jones E. L-Carnitine treatment in the hyperlipidemic rabbit. Metabolism 1987;36:1192-6.
  • 23
    • 0142183261 scopus 로고    scopus 로고
    • Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin-diabetic rat aorta
    • Irat AM, Aktan F, Ozansoy G. Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin-diabetic rat aorta. J Pharm Pharmacol 2003;55:1389-95.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 1389-1395
    • Irat, A.M.1    Aktan, F.2    Ozansoy, G.3
  • 24
    • 0034834828 scopus 로고    scopus 로고
    • Sayed-Ahmed MM, Khattab MM, Gad MZ, Mostafa N. L-Carnitine prevents the progression of atherosclerotic lesions in hypercholesterolaemic rabbits. Pharmacol Res 2001;44:235-42.
    • Sayed-Ahmed MM, Khattab MM, Gad MZ, Mostafa N. L-Carnitine prevents the progression of atherosclerotic lesions in hypercholesterolaemic rabbits. Pharmacol Res 2001;44:235-42.
  • 25
    • 58149387523 scopus 로고    scopus 로고
    • Mitwalli AH, Al-Wakeel JS, Alam A, et al. L-Carnitine supplementation in hemodialysis patients. Saudi J Kidney Dis Transpl 2005;16:17-22.
    • Mitwalli AH, Al-Wakeel JS, Alam A, et al. L-Carnitine supplementation in hemodialysis patients. Saudi J Kidney Dis Transpl 2005;16:17-22.
  • 26
    • 11844299586 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • American Diabetes Association
    • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2005;28:S37-42.
    • (2005) Diabetes Care , vol.28
  • 27
    • 0035897696 scopus 로고    scopus 로고
    • Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel on Detection
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-97.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 28
    • 0031578033 scopus 로고    scopus 로고
    • Recommendations guiding physicians in biomedical research involving human subjects
    • World Medical Association Declaration of Helsinki
    • World Medical Association Declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. JAMA 1997;277:925-6.
    • (1997) JAMA , vol.277 , pp. 925-926
  • 29
    • 0032438431 scopus 로고    scopus 로고
    • Oxidative modification of low-density lipoproteins in atherothrombosis
    • Holvoet P. Oxidative modification of low-density lipoproteins in atherothrombosis. Acta Cardiol 1998;53:253-60.
    • (1998) Acta Cardiol , vol.53 , pp. 253-260
    • Holvoet, P.1
  • 30
    • 0034303187 scopus 로고    scopus 로고
    • Sirtori CR, Calabresi L, Ferrara S, et al. L-Carnitine reduces plasma lipoprotein(a) levels in patients with hyper Lp(a). Nutr Metab Cardiovasc Dis 2000;10:247-51.
    • Sirtori CR, Calabresi L, Ferrara S, et al. L-Carnitine reduces plasma lipoprotein(a) levels in patients with hyper Lp(a). Nutr Metab Cardiovasc Dis 2000;10:247-51.
  • 31
    • 0019323872 scopus 로고
    • Effect of L-carnitine on lipid pattern in haemodialysis
    • Casciani CU, Caruso U, Cravotto E, et al. Effect of L-carnitine on lipid pattern in haemodialysis. Lancet 1980;316:1309-10.
    • (1980) Lancet , vol.316 , pp. 1309-1310
    • Casciani, C.U.1    Caruso, U.2    Cravotto, E.3
  • 32
    • 0020592202 scopus 로고
    • Favorable effects of L-carnitine treatment on hypertriglyceridemia in hemodialysis patients: Decisive role of low levels of high-density lipoprotein-cholesterol
    • Vacha GM, Giorcelli G, Siliprandi N, Corsi M. Favorable effects of L-carnitine treatment on hypertriglyceridemia in hemodialysis patients: decisive role of low levels of high-density lipoprotein-cholesterol. Am J Clin Nutr 1983;38:532-40.
    • (1983) Am J Clin Nutr , vol.38 , pp. 532-540
    • Vacha, G.M.1    Giorcelli, G.2    Siliprandi, N.3    Corsi, M.4
  • 33
    • 0020596660 scopus 로고
    • Effect of carnitine on lipid metabolism in the newborn. I. Carnitine supplementation during total parenteral nutrition in the first 48 hours of life
    • Orzali A, Donzelli F, Enzi G, Rubaltelli FF. Effect of carnitine on lipid metabolism in the newborn. I. Carnitine supplementation during total parenteral nutrition in the first 48 hours of life. Biol Neonate 1983;43:186-90.
    • (1983) Biol Neonate , vol.43 , pp. 186-190
    • Orzali, A.1    Donzelli, F.2    Enzi, G.3    Rubaltelli, F.F.4
  • 34
    • 0020564648 scopus 로고
    • Carnitine and carnitine esters in plasma and adipose tissue of chronic uremic patients undergoing hemodialysis
    • Penn D, Schmidt-Sommerfeld E. Carnitine and carnitine esters in plasma and adipose tissue of chronic uremic patients undergoing hemodialysis. Metabolism 1983;32:806-9.
    • (1983) Metabolism , vol.32 , pp. 806-809
    • Penn, D.1    Schmidt-Sommerfeld, E.2
  • 35
    • 0033286476 scopus 로고    scopus 로고
    • Nitric oxide, cytochrome c and mitochondria
    • Brown GC, Borutaite V. Nitric oxide, cytochrome c and mitochondria. Biochem Soc Symp 1999;66:17-25.
    • (1999) Biochem Soc Symp , vol.66 , pp. 17-25
    • Brown, G.C.1    Borutaite, V.2
  • 37
    • 0035976362 scopus 로고    scopus 로고
    • Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity
    • Binienda ZK, Ali SF. Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity. Toxicol Lett 2001;125:67-73.
    • (2001) Toxicol Lett , vol.125 , pp. 67-73
    • Binienda, Z.K.1    Ali, S.F.2
  • 38
    • 0033981292 scopus 로고    scopus 로고
    • Caffeine, carnitine and choline supplementation of rats decreases body fat and serum leptin concentration as does exercise
    • Hongu N, Sachan DS. Caffeine, carnitine and choline supplementation of rats decreases body fat and serum leptin concentration as does exercise. J Nutr 2000;130:152-7.
    • (2000) J Nutr , vol.130 , pp. 152-157
    • Hongu, N.1    Sachan, D.S.2
  • 39
    • 0037228077 scopus 로고    scopus 로고
    • Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women
    • Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women. J Nutr 2003;133:84-9.
    • (2003) J Nutr , vol.133 , pp. 84-89
    • Hongu, N.1    Sachan, D.S.2
  • 40
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000;87:840-4.
    • (2000) Circ Res , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 41
    • 0030034465 scopus 로고    scopus 로고
    • Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
    • Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1996;97:22-8.
    • (1996) J Clin Invest , vol.97 , pp. 22-28
    • Ting, H.H.1    Timimi, F.K.2    Boles, K.S.3    Creager, S.J.4    Ganz, P.5    Creager, M.A.6
  • 42
    • 0038389442 scopus 로고    scopus 로고
    • Neuroprotective effects of L-carnitine in induced mitochondrial dysfunction
    • Binienda ZK. Neuroprotective effects of L-carnitine in induced mitochondrial dysfunction. Ann N Y Acad Sci 2003;993:289-95.
    • (2003) Ann N Y Acad Sci , vol.993 , pp. 289-295
    • Binienda, Z.K.1
  • 43
    • 0037626727 scopus 로고    scopus 로고
    • Effects of levocarnitine on mitochondrial antioxidant systems and oxidative stress in aged rats
    • Kumaran S, Deepak B, Naveen B, Panneerselvam C. Effects of levocarnitine on mitochondrial antioxidant systems and oxidative stress in aged rats. Drugs R D 2003;4:141-7.
    • (2003) Drugs R D , vol.4 , pp. 141-147
    • Kumaran, S.1    Deepak, B.2    Naveen, B.3    Panneerselvam, C.4
  • 44
    • 0034466662 scopus 로고    scopus 로고
    • Selective modulation of carnitine long-chain acyltransferase activities: Kinetics, inhibitors, and active sites of COT and CPT-II
    • Ramsay RR, Gandour RD. Selective modulation of carnitine long-chain acyltransferase activities: kinetics, inhibitors, and active sites of COT and CPT-II. Adv Exp Med Biol 1999;466:103-9.
    • (1999) Adv Exp Med Biol , vol.466 , pp. 103-109
    • Ramsay, R.R.1    Gandour, R.D.2
  • 45
    • 0024553760 scopus 로고
    • Effect of carnitine on malondialdehyde, taurine and glutathione levels in heart of rats subjected to myocardial stress by isoproterenol
    • Sushamakumari S, Jayadeep A, Kumar JS, Menon VP. Effect of carnitine on malondialdehyde, taurine and glutathione levels in heart of rats subjected to myocardial stress by isoproterenol. Indian J Exp Biol 1989;27:134-7.
    • (1989) Indian J Exp Biol , vol.27 , pp. 134-137
    • Sushamakumari, S.1    Jayadeep, A.2    Kumar, J.S.3    Menon, V.P.4
  • 46
    • 0037121594 scopus 로고    scopus 로고
    • Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice
    • Yasui F, Matsugo S, Ishibashi M, et al. Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice. Neurosci Lett 2002;334:177-80.
    • (2002) Neurosci Lett , vol.334 , pp. 177-180
    • Yasui, F.1    Matsugo, S.2    Ishibashi, M.3
  • 47
    • 0037945488 scopus 로고    scopus 로고
    • The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus
    • Derosa G, Cicero AF, Gaddi A, Mugellini A, Ciccarelli L, Fogari R. The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Clin Ther 2003;25:1429-39.
    • (2003) Clin Ther , vol.25 , pp. 1429-1439
    • Derosa, G.1    Cicero, A.F.2    Gaddi, A.3    Mugellini, A.4    Ciccarelli, L.5    Fogari, R.6
  • 48
    • 33748132593 scopus 로고    scopus 로고
    • Efficacy and tolerability of combined treatment with L-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus
    • Solfrizzi V, Capurso C, Colacicco AM, et al. Efficacy and tolerability of combined treatment with L-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus. Atherosclerosis 2006;188:455-61.
    • (2006) Atherosclerosis , vol.188 , pp. 455-461
    • Solfrizzi, V.1    Capurso, C.2    Colacicco, A.M.3
  • 49
    • 38949140508 scopus 로고    scopus 로고
    • Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue
    • Malaguarnera M, Gargante MP, Cristaldi E, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr 2008;46:181-90.
    • (2008) Arch Gerontol Geriatr , vol.46 , pp. 181-190
    • Malaguarnera, M.1    Gargante, M.P.2    Cristaldi, E.3
  • 50
    • 33645099306 scopus 로고    scopus 로고
    • L-carnitine reduces severity of physical and mental fatigue and improves daily activities in the elderly
    • Malaguarnera M, Di Mauro A, Gargante PM, Rampello L. L-carnitine reduces severity of physical and mental fatigue and improves daily activities in the elderly. South Med J 2006;99:315-6.
    • (2006) South Med J , vol.99 , pp. 315-316
    • Malaguarnera, M.1    Di Mauro, A.2    Gargante, P.M.3    Rampello, L.4
  • 51
    • 0043163608 scopus 로고    scopus 로고
    • Levocarnitine administration in elderly subjects with rapid muscle fatigue: Effect on body composition, lipid profile and fatigue
    • Pistone G, Marino A, Leotta C, Dell'Arte S, Finocchiaro G, Malaguarnera M. Levocarnitine administration in elderly subjects with rapid muscle fatigue: effect on body composition, lipid profile and fatigue. Drugs Aging 2003;20:761-7.
    • (2003) Drugs Aging , vol.20 , pp. 761-767
    • Pistone, G.1    Marino, A.2    Leotta, C.3    Dell'Arte, S.4    Finocchiaro, G.5    Malaguarnera, M.6
  • 52
    • 0026511875 scopus 로고
    • Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man
    • Regnström J, Nilsson J, Tornvall P, Landou C, Hamsten A. Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 1992;339:1183-6.
    • (1992) Lancet , vol.339 , pp. 1183-1186
    • Regnström, J.1    Nilsson, J.2    Tornvall, P.3    Landou, C.4    Hamsten, A.5
  • 53
    • 0019796887 scopus 로고
    • Lipid peroxide levels of serum lipoprotein fractions of diabetic patients
    • Nishigaki I, Hagihara M, Tsunekawa H, Maseki M, Yagi K. Lipid peroxide levels of serum lipoprotein fractions of diabetic patients. Biochem Med 1981;25:373-8.
    • (1981) Biochem Med , vol.25 , pp. 373-378
    • Nishigaki, I.1    Hagihara, M.2    Tsunekawa, H.3    Maseki, M.4    Yagi, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.