Disruption of ATP binding destabilizes NPM/B23 and inhibits anti-apoptotic function

Journal of Biochemistry and Molecular Biology

Volumn 41, Issue 12, 2008, Pages 840-845

  Choi, Joung Woo ^a   Lee, Sang Bae ^a   Ahn, Jee Yin ^a   Lee, Kyung Hoon ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Apoptosis; ATR Cell survival; Nucleophosmin B23

Indexed keywords

EID: 58149352992     PISSN: 12258687     EISSN: 02191024     Source Type: Journal    
DOI: 10.5483/bmbrep.2008.41.12.840     Document Type: Article

References (20)

1. Spector, D. L., Ochs, R. L. and Busch, H. (1984) Silver staining, immunofluorescence, and immunoelectron microscopic localization of nucleolar phosphoproteins B23 and C23. Chromosoma 90, 139-148.
2. Busch, H. and Smetana, K. (1970) The nucleolus. Academic Press, New York, USA.
3. Borer, R. A., Lehner, C. F., Eppenberger, H. M. and Nigg, E. A. (1989) Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell 56, 379-390.
4. Yung, B. Y., Bor, A. M. and Yang, Y. H. (1990) Immunolocalization of phosphoprotein B23 in proliferating and non-proliferating HeLa cells. Int. J. Cancer 46, 272-275.
5. Finch, R. A., Revankar, G. R. and Chan, P. K. (1993) Nucleolar localization of nucleophosmin/B23 requires GTP. J. Biol. Chem. 268, 5823-5827.
6. Chou, Y. H. and Yung, B. Y. (1995) Cell cycle phase-dependent changes of localization and oligomerization states of nucleophosmin / B23. Biochem. Biophys. Res. Commun. 217, 313-325.
7. Finch, R. A. and Chan, P. K. (1996) ATP depletion affects NPM translocation and exportation of rRNA from nuclei. Biochem. Biophys. Res. Commun. 222, 553-558.
8. Wu, M. H., Lam, C. Y. and Yung, B. Y. (1995) Translocation of nucleophosmin from nucleoli to nucleoplasm requires ATP. Biochem. j. 305, 987-992.
9. Chang, J. H., Lin, J. Y., Wu, M. H. and Yung, B. Y. (1998) Evidence for the ability of nucleophosmin/B23 to bind ATP. Biochem. J. 329, 539-544.
10. Han, S. I., Kim, Y. S. and Kim, T. H. (2008) Role of apoptotic and necrotic cell death under physiologic conditions. BMB reports 41, 1-10.
11. Choi, J. W., Lee, S. B., Kim, C. K., Lee, K. H., Cho, S. W. and Ahn, J. Y. (2008) Lysine 263 residue of NPM/B23 is essential for regulating ATP binding and B23 stability. FEBS Letters 582, 1073-1080.
12. Jeong, S.Y. and Seol, D.W. (2008) The role of mitochondria in apoptosis. BMB Rep. 41, 11-22.
13. Horky, M., Wurzer, G., Kotala, V., Anton, M., Vojtesek, B., Vacha, J. and Wesierska-Gadek, J. (2001) Segregation of nucleolar components coincides with caspase-3 activation in cisplatin-treated HeLa cells. J. Cell. Sci. 114, 663-670.
14. Olson, M. O., Hingorani, K. and Szebeni, A. (2002) Conventional and nonconventional roles of the nucleolus. Int. Rev. Cytol. 219, 199-266.
15. Ahn, J. Y., Liu, X., Cheng, D., Peng, J., Chan, P. K., Wade, P. A. and Ye, K. (2005) Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD. Mol. Cell 18, 435-445.
16. Chou, C. C. and Yung, B. Y. (2001) Increased stability of nucleophosmin/B23 in anti-apoptotic effect of ras during serum deprivation. Mol. Pharm. 59, 38-45.
17. Itahana, K., Bhat, K. P., Jin, A., Itahana, Y., Hawke, D., Kobayashi, R. and Zhang, Y. (2003) Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol. Cell 12, 1151-1164.
18. Yung, B. Y., Busch, H. and Chan, P. K. (1986) Effects of luzopeptins on protein B23 translocation and ribosomal RNA synthesis in HeLa cells. Cancer Res. 46, 922-925.
19. Enomoto, T., Lindstrom, M. S., Jin, A., Ke, H. and Zhang, Y. (2006) Essential Role of the B23/NPM Core Domain in Regulating ARF Binding and B23 Stability. J. Biol. Chem. 281, 18463-18472.
20. Liu, X., Zou, H., Slaughter, C. and Wang, X. (1997) DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis. Cell 89, 175-184.