Pre-surgical training ameliorates orbitofrontal-mediated impairments in spatial reversal learning

Behavioural Brain Research

Volumn 197, Issue 2, 2009, Pages 469-475

  Boulougouris, Vasileios ^a   Robbins, Trevor W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Discrimination; Disinhibition; Excitotoxic lesion; Operant behaviour; Orbitofrontal cortex; Spatial reversal learning

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN DAMAGE; BRAIN DYSFUNCTION; COGNITION; EXCITOTOXICITY; LEARNING; LEARNING TEST; MALE; NONHUMAN; ORBITAL CORTEX; PERFORMANCE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; REINFORCEMENT; SPATIAL DISCRIMINATION;

ANIMALS; CEREBRAL CORTEX; COGNITION; CONDITIONING, OPERANT; DISCRIMINATION LEARNING; FRONTAL LOBE; MALE; QUINOLINIC ACID; RATS; RATS, INBRED STRAINS; REACTION TIME; REINFORCEMENT (PSYCHOLOGY); REINFORCEMENT SCHEDULE; REVERSAL LEARNING; SPACE PERCEPTION; SPATIAL BEHAVIOR;

EID: 58149345008     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2008.10.005     Document Type: Article

References (28)

1. Bohn I., Giertler C., and Hauber W. Orbital prefrontal cortex and guidance of instrumental behaviour in rats under reversal conditions. Behav Brain Res 143 (2003) 49-56
2. Boulougouris V., Dalley J.W., and Robbins T.W. Effects of orbitofrontal, infralimbic and prelimbic cortical lesions on serial spatial reversal learning in the rat. Behav Brain Res 179 (2007) 219-228
3. Butter C.M. Perseveration in extinction and in discrimination reversal learning following selective frontal ablations in Macaca mulatta. Physiol Behav 4 (1969) 163-171
4. Chudasama Y., Kralik J.D., and Murray E.A. Rhesus monkeys with orbital prefrontal cortex lesions can learn to inhibit prepotent responses in the reversed reward contingency task. Cereb Cortex 17 (2007) 1154-1159
5. Chudasama Y., and Robbins T.W. Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: further evidence for the functional heterogeneity of the rodent frontal cortex. J Neurosci 23 (2003) 8771-8780
6. Crofts H.S., Dalley J.W., Collins P., Van Denderen J.C., Everitt B.J., Robbins T.W., et al. Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set. Cereb Cortex 11 (2001) 1015-1026
7. Dias R., Robbins T.W., and Roberts A.C. Dissociable forms of inhibitory control within prefrontal cortex with an analog of the Wisconsin Card Sort Test: restriction to novel situations and independence from "on-line" processing. J Neurosci 17 (1997) 9285-9297
8. Dias R., Robbins T.W., and Roberts A.C. Dissociation in prefrontal cortex of affective and attentional shifts. Nature 380 (1996) 69-72
9. Eichenbaum H., Clegg R.A., and Feeley A. Reexamination of functional subdivisions of the rodent prefrontal cortex. Exp Neuroli 79 (1983) 434-451
10. Eichenbaum H., Shedlack K.J., and Eckmann K.W. Thalamocortical mechanisms in odor-guided behavior. I. Effects of lesions of the mediodorsal thalamic nucleus and frontal cortex on olfactory discrimination in the rat. Brain Behav Evol 17 (1980) 255-275
11. Fellows L.K., and Farah M.J. Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm. Brain 126 (2003) 1830-1837
12. Ferry A.T., Lu X.C., and Price J.L. Effects of excitotoxic lesions in the ventral striatopallidal-thalamocortical pathway on odor reversal learning: inability to extinguish an incorrect response. Exp Brain Res 131 (2000) 320-335
13. Frank M.J., Seeberger L.C., and O'reilly R.C. By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science 306 (2004) 1940-1943
14. Izquierdo A., and Murray E.A. Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys. J Neurophysiol 91 (2004) 2023-2039
15. Joel D., Doljansky J., Roz N., and Rehavi M. Role of the orbital cortex and the serotonergic system in a rat model of obsessive compulsive disorder. Neuroscience 130 (2005) 25-36
16. Joel D., Doljansky J., and Schiller D. 'Compulsive' lever pressing in rats is enhanced following lesions to the orbital cortex, but not to the basolateral nucleus of the amygdala or to the dorsal medial prefrontal cortex. Eur J Neurosci 21 (2005) 2252-2262
17. Jones B., and Mishkin M. Limbic lesions and the problem of stimulus-reinforcement associations. Exp Neurol 36 (1972) 362-377
18. Kim J., and Ragozzino M.E. The involvement of the orbitofrontal cortex in learning under changing task contingencies. Neurobiol Learn Mem 83 (2005) 125-133
19. Mackintosh N.J. The Psychology of Animal Learning (1974), Academic Press, London
20. McAlonan K., and Brown V.J. Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat. Behav Brain Res 146 (2003) 97-103
21. Miller E.K. The prefrontal cortex and cognitive control. Nat Rev Neurosci 1 (2000) 59-65
22. Murphy F.C., Michael A., Robbins T.W., and Sahakian B.J. Neuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performance. Psychol Med 33 (2003) 455-467
23. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd ed. (1998), Academic, Sydney
24. Rogers R.D., Andrews T.C., Grasby P.M., Brooks D.J., and Robbins T.W. Contrasting cortical and subcortical activations produced by attentional set-shifting and reversal learning in humans. J Cogn Neurosci 12 (2000) 142-162
25. Rolls E.T., Hornak J., Wade D., and McGrath J. Emotion related learning in patients with social and emotional changes associated with frontal lobe damage. J Neurol Neurosurg Psychiatry 57 (1994) 1518-1524
26. Schoenbaum G., Chiba A.A., and Gallagher M. Rapid changes in functional connectivity in orbitofrontal cortex and basolateral amygdala during learning and reversal. J Neurosci 20 (2000) 5179-5189
27. Schoenbaum G., Nugent S., Saddoris M.P., and Setlow B. Orbitofrontal lesions in the rats impair reversal but not acquisition of go, no-go odor discriminations. NeuroReport 13 (2002) 885-890
28. Schoenbaum G., Setlow B., and Ramus S.J. A systems approach to orbitofrontal cortex function: recordings in rat orbitofrontal cortex reveal interactions with different learning systems. Behav Brain Res 146 (2003) 19-29