Synthesis of the CDK-inhibitor paullone by cyclization of a deprotonated α-aminonitrile

Synthesis

Volumn , Issue 24, 2008, Pages 3941-3944

  Opatz, Till ^a   Ferenc, Dorota ^b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

aminonitriles; Deprotonation; Indoles; Michael addition

Indexed keywords

ALDEHYDES; AMINES; CYCLIZATION;

INDOLES; MICHAEL ADDITION; STRECKER REACTIONS; SYNTHESIS OF;

SYNTHESIS (CHEMICAL);

BENZALDEHYDE DERIVATIVE; CINNAMIC ACID DERIVATIVE; ETHYL 2 [[2 (TERT BUTOXYCARBONYLAMINO)BENZYLIDENE]AMINO]CINNAMATE; ETHYL 2 [[[2 (TERT BUTOXYCARBONYLAMINO)PHENYL]CYANOMETHYL]AMINO]CINNAMATE; ETHYL [2 [2 (TERT BUTOXYCARBONYLAMINO)PHENYL] 1H INDOL 3 YL]ACETATE; LACTAM DERIVATIVE; NITRILE; PAULLONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; PROTON TRANSPORT; STRECKER SYNTHESIS;

EID: 58149342068     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0028-1083250     Document Type: Article

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