Epilepsies in dementia and neurodegenerative disorders;Epilepsien bei demenziellen und neurodegenerativen erkrankungen

Aktuelle Neurologie

Volumn 35, Issue 10, 2008, Pages 511-518

  Reinsberger, Claus ^a   Hopp, P ^b   Kramer G ^c   Claßen, Joseph ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b Fachkrankenhaus für Neurologie ^*

^c SWISS EPILEPSY CENTER   (Switzerland)

Author keywords

Dementia; Dementia of the Alzheimer type; Epilepsy; Neurodegenerative disorders

Indexed keywords

ANTICONVULSIVE AGENT; CHLORPROMAZINE; CLOZAPINE; DONEPEZIL; GINKGO BILOBA EXTRACT; MEMANTINE; NEUROLEPTIC AGENT; NOOTROPIC AGENT; OLANZAPINE; QUETIAPINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ALZHEIMER DISEASE; BULBAR PARALYSIS; COGNITIVE DEFECT; CORTICOBASAL DEGENERATION; CREUTZFELDT JAKOB DISEASE; DEGENERATIVE DISEASE; DEMENTIA; DIFFERENTIAL DIAGNOSIS; DIFFUSE LEWY BODY DISEASE; DISEASE ASSOCIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN SYNDROME; ELECTROENCEPHALOGRAPHY; EPIDEMIOLOGICAL DATA; EPILEPSY; FATAL FAMILIAL INSOMNIA; FRIEDREICH ATAXIA; FRONTOTEMPORAL DEMENTIA; GERIATRIC PATIENT; GERSTMANN STRAUSSLER SCHEINKER SYNDROME; HUMAN; HUNTINGTON CHOREA; MEMORY DISORDER; MOTOR NEURON DISEASE; MYOCLONUS EPILEPSY; PARKINSONISM; PATHOGENESIS; PATHOPHYSIOLOGY; PREVALENCE; PRIMARY PROGRESSIVE APHASIA; PROGRESSIVE SUPRANUCLEAR PALSY; REVIEW; RISK FACTOR; SEMANTIC DEMENTIA; SPINAL MUSCULAR ATROPHY; SPINOCEREBELLAR DEGENERATION; SYMPTOM;

EID: 58149331697     PISSN: 03024350     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0028-1090105     Document Type: Review

References (124)

1. Secretariat Population Division of the Department of Economic and Social Affairs of the United Nations. World Population Prospects: The 2006 Revision; 2006
2. Hebert LE, Scherr PA, Bienias JL et al. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurology 2003; 60: 1119-1122
3. Krämer G. Epilepsien im höheren Lebensalter. Stuttgart. New York: Georg Thieme Verlag, 1999
4. Tallis R, Hall G, Craig I et al. How common are epileptic seizures in old age? Age Ageing 1991; 20: 442-448
5. Brust JCM. Seizures in the elderly. In: Lüders HO, Noachtar S, eds. Epileptic seizures. New York: Churchill Livingstone, 2000: 529-538
6. LaRoche SM, Helmers SL. Epilepsy in the elderly. Neurologist 2003; 9: 241-249
7. Leppik IE, Coyd JC. Treatment of epilepsy in the elderly. In: Levy RH, Mattson RH, Meldrun BS, Perucca E, eds. Antiepileptic Drugs. Philadelphia: Lippincott, Williams & Wilkins, 2002: 149-168
8. Rowan AJ. Epilepsy and the elderly. Epilepsy Behav 2000; 1: S12-S14
9. Stephen LJ, Brodie MJ. Epilepsy in elderly people. Lancet 2000; 355: 1441-1446
10. Gaitatzis A, Carroll K, Majeed A et al. The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia 2004; 45: 1613-1622
11. Bourdet SV, Gidal BE, Alldredge BK. Pharmacologic management of epilepsy in the elderly. J Am Pharm Assoc (Wash) 2001; 41: 421-436
12. Dickson DW. Neurodegeneration: the molecular pathology of dementia and movement disorders. Basel: ISN Neuropathology Press, 2003
13. Bengel D, Supprian T, Lesch KP. Koinzidenz von Chorea Huntington und Epilepsie. Nervenarzt 1997; 68: 270-273
14. Filla A, De Michele G, Cocozza S et al. Early onset autosomal dominant dementia with ataxia, extrapyramidal features, and epilepsy. Neurology 2002; 58: 922-928
15. Matsuura T, Achari M, Khajavi M et al. Mapping of the gene for a novel spinocerebellar ataxia with pure cerebellar signs and epilepsy. Ann Neurol 1999; 45: 407-411
16. Sperfeld AD, Collatz MB, Baier H et al. FTDP-17: an early-onset phenotype with parkinsonism and epileptic seizures caused by a novel mutation. Ann Neurol 1999; 46: 708-715
17. Inazuki G, Baba K, Naito H. Electroencephalographs findings of hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Jpn J Psychiatry Neurol 1989; 43: 213-220
18. Nielsen JE, Sorensen SA, Hasholt L et al. Dentatorubral- pallidoluysian atrophy. Clinical features of a five-generation Danish family. Mov Disord 1996; 11: 533-541
19. Amatniek JC, Hauser WA, Delcastillo-Castaneda C et al. Incidence and predictors of seizures in patients with Alzheimer's disease. Epilepsia 2006; 47: 867-872
20. Hauser WA, Morris ML, Heston LL et al. Seizures and myoclonus in patients with Alzheimer's disease. Neurology 1986; 36: 1226-1230
21. Hesdorffer DC, Hauser WA, Annegers JF et al. Dementia and adult-onset unprovoked seizures. Neurology 1996; 46: 727-730
22. McAreavey MJ, Bollinger BR, Fenton GW. Epileptic seizures in elderly patients with dementia. Epilepsia 1992; 33: 657-660
23. Mendez MF, Catanzaro P, Doss RC et al. Seizures in Alzheimer's disease: clinicopathologic study. J Geriatr Psychiatry Neurol 1994; 7: 230-233
24. Risse SC, Lampe TH, Bird TD et al. Myoclonus, seizures, and paratonia in Alzheimer disease. Alzheimer Dis Assoc Disord 1990; 4: 217-225
25. Romanelli MF, Morris JC, Ashkin K et al. Advanced Alzheimer's disease is a risk factor for late-onset seizures. Arch Neurol 1990; 47: 847-850
26. Volicer L, Smith S, Volicer BJ. Effect of seizures on progression of dementia of the Alzheimer type. Dementia 1995; 6: 258-263
27. Lozsadi DA, Larner AJ. Prevalence and causes of seizures at the time of diagnosis of probable Alzheimer's disease. Dement Geriatr Cogn Disord 2006; 22: 121-124
28. Forsgren L, Bucht G, Eriksson S et al. Incidence and clinical characterization of unprovoked seizures in adults: a prospective population-based study. Epilepsia 1996; 37: 224-229
29. Hatanpaa KJ, Blass DM, Pletnikova O et al. Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology 2004; 63: 538-542
30. Daniel SE, de Bruin VM, Lees AJ. The clinical and pathological spectrum of Steele-Richardson-Olszewski syndrome (progressive supra-nuclear palsy): a reappraisal. Brain 1995; 118: 759-770
31. Nygaard TG, Duvoisin RC, Manocha M et al. Seizures in progressive supranuclear palsy. Neurology 1989; 39: 138-140
32. Mahapatra RK, Edwards MJ, Schott JM et al. Corticobasal degeneration. Lancet Neurology 2004; 3: 736-743
33. Yakovlev PI. Epilepsy and parkinsonism. N Engl J Med 1928; 198: 629-638
34. Bodenmann P, Ghika J, Van Melle G et al. Neurological comorbidity in parkinsonism. Rev Neurol (Paris) 2001; 157: 45-54
35. Tagliati M, Perl DP, Drayer B et al. Progressive dementia and gait disorder in a 78 year old woman. J Neurol Neurosurg Psychiatry 2000; 68: 526-531
36. Vercueil L. Parkinsonism and epilepsy: case report and reappraisal of an old question. Epilepsy Behav 2000; 1: 128-130
37. DeLong MR, Alexander GE, Georgopoulos AP et al. Role of basal ganglia in limb movements. Hum Neurobiol 1984; 2: 235-244
38. Norden AD, Blumenfeld H. The role of subcortical structures in human epilepsy. Epilepsy Behav 2002; 3: 219-231
39. Chabardes S, Kahane P, Minotti L et al. Deep brain stimulation in epilepsy with particular reference to the subthalamic nucleus. Epileptic Disord 2002; 4 (Suppl. 3): S83-93
40. Weiner MF, Hynan LS, Parikh B et al. Can alzheimer's disease and dementias with Lewy bodies be distinguished clinically? J Geriatr Psychiatry Neurol 2003; 16: 245-250
41. Peset V, Castillo A, Brocalero A et al. Epilepsy and dementia due to Lewy bodies. Rev Neurol 2001; 33: 895-896
42. Quinn N. Multiple system atrophy - the nature of the beast. J Neurol Neurosurg Psychiatry 1989; Suppl: 78-89
43. Deransart C, Depaulis A. The control of seizures by the basal ganglia? A review of experimental data. Epileptic Disord 2002; 4 (Suppl. 3): S61-72
44. Brackenridge CJ. Factors influencing dementia and epilepsy in Huntington's disease of early onset. Acta Neurol Scand 1980; 62: 305-311
45. Siesling S, Vegter-van der Vlis M, Roos RA. Juvenile Huntington disease in the Netherlands. Pediatr Neurol 1997; 17: 37-43
46. Ruocco HH, Lopes-Cendes I, Laurito TL et al. Clinical presentation of juvenile Huntington disease. Arq Neuropsiquiatr 2006; 64: 5-9
47. Gonzalez-Alegre P, Afifi AK. Clinical characteristics of childhood-onset (juvenile) Huntington disease: report of 12 patients and review of the literature. J Child Neurol 2006; 21: 223-229
48. Subramony SH, Filla A. Autosomal dominant spinocerebellar ataxias ad infinitum? Neurology 2001; 56: 287-289
49. Warner TT, Lennox GG, Janota I et al. Autosomal-dominant dentatorubropallidoluysian atrophy in the United Kingdom. Mov Disord 1994; 9: 289-296
50. Iizuka R, Hirayama K, Maehara KA. Dentato-rubro-pallido-luysian atrophy: a clinico-pathological study. J Neurol Neurosurg Psychiatry 1984; 47: 1288-1298
51. Remillard G, Andermann F, Blitzer L et al. Electroencephalographs findings in Friedreich's ataxia. Can J Neurol Sci 1976; 3: 309-312
52. Golomb MR, Illner A, Christensen CK et al. A child with Friedreich's ataxia and epilepsy. J Child Neurol 2005; 20: 248-250
53. Cokgor I, Rozear M, Morgenlander JC. Seizures and Creutzfeldt-Jakob disease. A case report and series review. N C Med J 1999; 60: 108-109
54. Lee K, Haight E, Olejniczak P. Epilepsia partialis continua in Creutzfeldt-Jakob disease. Acta Neurol Scand 2000; 102: 398-402
55. Fernandez-Torre JL, Solar DM, Astudillo A et al. Creutzfeldt-Jakob disease and non-convulsive status epilepticus: a clinical and electroencephalographic follow-up study. Clin Neurophysiol 2004; 115: 316-319
56. Karatas H, Dericioglu N, Kursun O et al. Creutzfeldt-Jakob disease presenting as hyperparathyroidism and generalized tonic status epilepticus. Clin EEG Neurosci 2007; 38: 203-206
57. Hung CI, Wang PS, Soong BW et al. Blind source separation of concurrent disease-related patterns from EEG in Creutzfeldt-Jakob disease for assisting early diagnosis. Ann Biomed Eng 2007; 35: 2168-2179
58. Floel A, Reilmann R, Frese A et al. Anticonvulsants for Creutzfeldt-Jakob disease? Lancet 2003; 361: 224
59. Collins S, McLean CA, Masters CL. Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia, and kuru: a review of these less common human transmissible spongiform encephalopathies. J Clin Neurosci 2001; 8: 387-397
60. Haliloglu G, Chattopadhyay A, Skorodis L et al. Spinal muscular atrophy with progressive myoclonic epilepsy: report of new cases and review of the literature. Neuropediatrics 2002; 33: 314-319
61. Striano P, Boccella P, Sarappa C et al. Spinal muscular atrophy and progressive myoclonic epilepsy: one case report and characteristics of the epileptic syndrome. Seizure 2004; 13: 582-586
62. Shahwan A, Farrell M, Delanty N. Progressive myoclonic epilepsies: a review of genetic and therapeutic aspects. Lancet Neurology 2005; 4: 239-248
63. Widdess-Walsh P, Prayson RA, Cohen B et al. A 12-year-old girl with seizures and dementia. Brain Pathol 2007; 17: 464-465, 474
64. Haltia M. The neuronal ceroid-lipofuscinoses: from past to present. Biochim Biophys Acta 2006; 1762: 850-856
65. Gdynia HJ, Sperfeld AD, Ludolph AC. Neuronale Zeroidlipofuszinosen des Erwachsenenalters. Nervenarzt 2007; 78: 139-144
66. Gallus GN, Dotti MT, Federico A. Clinical and molecular diagnosis of cerebrotendinous xanthomatosis with a review of the mutations in the CYP27A1 gene. Neurol Sci 2006; 27: 143-149
67. Moller JC, Hamer HM, Oertel WH et al. Late-onset myoclonic epilepsy in Down's syndrome (LOMEDS). Seizure 2002; 11 (Suppl. A): 303-305
68. Crespel A, Gonzalez V, Coubes P et al. Senile myoclonic epilepsy of Genton: two cases in Down syndrome with dementia and late onset epilepsy. Epilepsy research 2007; 77: 165-168
69. De Simone R, Daquin G, Genton P. Senile myoclonic epilepsy in Down syndrome: a video and EEG presentation of two cases. Epileptic Disord 2006; 8: 223-227
70. Flierl-Hecht A, Pfafflin M, May TW et al. Werden Epilepsien bei älteren Menschen übersehen? Nervenarzt 2003; 74: 691-698
71. Tatum WO 4th, Ross J, Cole AJ. Epileptic pseudodementia. Neurology 1998; 50: 1472-1475
72. Tombini M, Koch G, Placidi F et al. Temporal lobe epileptic activity mimicking dementia: a case report. Eur J Neurol 2005; 12: 805-806
73. Josephs KA, Wai DF, Parisi JE. Hippocampal sclerosis in a case of Alzheimer's disease-like dementia with late onset intractable epilepsy. Eur J Neurol 2003; 10: 333-334
74. Lozsadi DA, Chadwick DW, Larner AJ. Late-onset temporal lobe epilepsy with unilateral mesial temporal sclerosis and cognitive decline: A diagnostic dilemma. Seizure 2008; 17: 473-476
75. Gallassi R, Morreale A, Di Sarro R et al. Epileptic amnesic syndrome. Epilepsia 1992; 33 (Suppl. 6): S21-25
76. Palmini AL, Gloor P, Jones-Gotman M. Pure amnestic seizures in temporal lobe epilepsy. Definition, clinical symptomatology and functional anatomical considerations. Brain 1992; 115: 749-769
77. Butler CR, Graham KS, Hodges JR et al. The syndrome of transient epileptic amnesia. Ann Neurol 2007; 61: 587-598
78. Gallassi R. Epileptic amnesic syndrome: an update and further considerations. Epilepsia 2006; 47 (Suppl. 2): 103-105
79. Butler CR, Zeman AZ. Recent insights into the impairment of memory in epilepsy: transient epileptic amnesia, accelerated long-term forgetting and remote memory impairment. Brain 2008; 131: 2243-2263
80. Menendez M. Down syndrome, Alzheimer's disease and seizures. Brain Dev 2005; 27: 246-252
81. Griffith HR, Martin RC, Bambara JK et al. Older adults with epilepsy demonstrate cognitive impairments compared with patients with amnestic mild cognitive impairment. Epilepsy Behav 2006; 8: 161-168
82. Ezquerra M, Carnero C, Blesa R et al. A presenilin 1 mutation (Ser169Pro) associated with early-onset AD and myoclonic seizures. Neurology 1999; 52: 566-570
83. Diaz-Arrastia R, Gong Y, Fair S et al. Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele. Archives of neurology 2003; 60: 818-822
84. Armon C, Peterson GW, Liwnicz BH. Alzheimer's disease underlies some cases of complex partial status epilepticus. J Clin Neurophysiol 2000; 17: 511-518
85. Janszky J, Hoppe M, Clemens Z et al. Spike frequency is dependent on epilepsy duration and seizure frequency in temporal lobe epilepsy. Epileptic Disord 2005; 7: 355-359
86. Krauss GL, Abdallah A, Lesser R et al. Clinical and EEG features of patients with EEG wicket rhythms misdiagnosed with epilepsy. Neurology 2005; 64: 1879-1883
87. Mushtaq R, Van Cott AC. Benign EEG variants. Am J Electroneurodiagnostic Technol 2005; 45: 88-101
88. Tatum WO 4th, Husain AM, Benbadis SR et al. Normal adult EEG and patterns of uncertain significance. J Clin Neurophysiol 2006; 23: 194-207
89. Ferreri F, Pauri F, Pasqualetti P et al. Motor cortex excitability in Alzheimer's disease: a transcranial magnetic stimulation study. Ann Neurol 2003; 53: 102-108
90. Di Lazzaro V, Oliviero A, Tonali PA et al. Noninvasive in vivo assessment of cholinergic cortical circuits in AD using transcranial magnetic stimulation. Neurology 2002; 59: 392-397
91. Di Lazzaro V, Oliviero A, Pilato F et al. Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2004; 75: 555-559
92. Palop JJ, Chin J, Roberson ED et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 2007; 55: 697-711
93. Cabrejo L, Guyant-Marechal L, Laquerriere A et al. Phenotype associated with APP duplication in five families. Brain 2006; 129: 2966-2976
94. Takao M, Ghetti B, Murrell JR et al. Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizures. J Neuropathol Exp Neurol 2001; 60: 1137-1152
95. Hogh P, Smith SJ, Scahill RI et al. Epilepsy presenting as AD: neuroimaging, electroclinical features, and response to treatment. Neurology 2002; 58: 298-301
96. Garrard J, Harms S, Hardie N et al. Antiepileptic drug use in nursing home admissions. Ann Neurol 2003; 54: 75-85
97. Cameron H, Macphee GJ. Anticonvulsant therapy in the elderly - a need for placebo controlled trials. Epilepsy Res 1995; 21: 149-157
98. Brodie MJ, Overstall PW, Giorgi I. Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. The UK Lamotrigine Elderly Study Group. Epilepsy Res 1999; 37: 81-87
99. Faught E. Monotherapy in adults and elderly persons. Neurology 2007; 69: S3-9
100. Gidal BE. Antiepileptic drug formulation and treatment in the elderly: biopharmaceutical considerations. Int Rev Neurobiol 2007; 81: 299-311
101. Perucca E, Aldenkamp A, Tallis R et al. Role of valproate across the ages. Treatment of epilepsy in the elderly. Acta Neurol Scand Suppl 2006; 184: 28-37
102. Leppik IE. Epilepsy in the elderly. Epilepsia 2006; 47 (Suppl. 1): 65-70
103. Thomas SV, Pradeep KS, Rajmohan SJ. First ever seizures in the elderly: a seven-year follow-up study. Seizure 1997; 6: 107-110
104. Meador KJ, Loring DW, Allen ME et al. Comparative cognitive effects of carbamazepine and phenytoin in healthy adults. Neurology 1991; 41: 1537-1540
105. Meador KJ, Loring DW, Huh K et al. Comparative cognitive effects of anticonvulsants. Neurology 1990; 40: 391-394
106. Meador KJ, Loring DW, Abney OL et al. Effects of carbamazepine and phenytoin on EEG and memory in healthy adults. Epilepsia 1993; 34: 153-157
107. Meador KJ, Loring DW, Moore EE et al. Comparative cognitive effects of phenobarbital, phenytoin, and valproate in healthy adults. Neurology 1995; 45: 1494-1499
108. Martin R, Kuzniecky R, Ho S et al. Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults. Neurology 1999; 52: 321-327
109. Aldenkamp AP, Baker G, Mulder OG et al. A multicenter, randomized clinical study to evaluate the effect on cognitive function of topiramate compared with valproate as add-on therapy to carbamazepine in patients with partial-onset seizures. Epilepsia 2000; 41: 1167-1178
110. Aldenkamp AP, De Krom M, Reijs R. Newer antiepileptic drugs and cognitive issues. Epilepsia 2003; 44 (Suppl. 4): 21-29
111. Granger AS. Ginkgo biloba precipitating epileptic seizures. Age Ageing 2001; 30: 523-525
112. Peltz G, Pacific DM, Noviasky JA et al. Seizures associated with memantine use. Am J Health Syst Pharm 2005; 62: 420-421
113. Babic T, Zurak N. Convulsions induced by donepezil. J Neurol Neurosurg Psychiatry 1999; 66: 410
114. Pisani F, Oteri G, Costa C et al. Effects of psychotropic drugs on seizure threshold. Drug Saf 2002; 25: 91-110
115. Foster R, Olajide D. A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care. J Psychopharmacol 2005; 19: 93-96
116. Hedges DW, Jeppson KG. New-onset seizure associated with quetiapine and olanzapine. Ann Pharmacother 2002; 36: 437-439
117. Dogu O, Sevim S, Kaleagasi HS. Seizures associated with quetiapine treatment. Ann Pharmacother 2003; 37: 1224-1227
118. Lee JW, Crismon ML, Dorson PG. Seizure associated with olanzapine. Ann Pharmacother 1999; 33: 554-556
119. Woolley J, Smith S. Lowered seizure threshold on olanzapine. Br J Psychiatry 2001; 178: 85-86
120. Aarts JH, Binnie CD, Smit AM et al. Selective cognitive impairment during focal and generalized epileptiform EEG activity. Brain 1984; 107: 293-308
121. Jokeit H, Ebner A. Long-term effects of refractory temporal lobe epilepsy on cognitive abilities: a cross sectional study. J Neurol Neurosurg Psychiatry 1999; 67: 44-50
122. Binnie CD. Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG? Lancet Neurology 2003; 2: 725-730
123. Briellmann RS, Berkovic SF, Syngeniotis A et al. Seizure-associated hippocampal volume loss: a longitudinal magnetic resonance study of temporal lobe epilepsy. Ann Neurol 2002; 51: 641-644
124. Berg AT, Langfitt J, Shinnar S et al. How long does it take for partial epilepsy to become intractable? Neurology 2003; 60: 186-190