Neurotrophins and their receptors in human lingual tonsil: An immunohistochemical analysis

Oncology Reports

Volumn 20, Issue 5, 2008, Pages 1201-1206

  Artico, Marco ^a   Bronzetti, Elena ^a   Felici, Laura M ^a   Alicino, Valentina ^a   Ionta, Brunella ^a   Bronzetti, Benedetto ^b   Magliulo, Giuseppe ^a   Grande, Claudia ^a   Zamai, Loris ^c   Pasquantonio, Guido ^d   De Vincentiis, Marco ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Nuovo Presidio Ospedaliero Cutroni Zodda   (Italy)

^c UNIVERSITY OF URBINO   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Human lingual tonsil; Immunohistochemistry; Neurotrophins; Receptors

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN 3 RECEPTOR; NEUROTROPHIN 4; NEUROTROPHIN RECEPTOR; PROTEIN P75; PROTEIN TYROSINE KINASE A; NERVE GROWTH FACTOR RECEPTOR;

ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INNERVATION; LYMPHOCYTE; MACROPHAGE; NERVOUS SYSTEM FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TONGUE; TONSILLITIS; ADENOID; BIOSYNTHESIS; METABOLISM; VASCULAR ENDOTHELIUM;

ADENOIDS; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTES; MACROPHAGES; NERVE GROWTH FACTORS; RECEPTORS, NERVE GROWTH FACTOR;

EID: 58149330711     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000130     Document Type: Article

References (49)

1. Brandtzaeg P: Immunology of tonsils and adenoids: everything the ENT surgeon needs to know. International Congress Series 1254: 89-99, 2003.
2. Brandtzaeg P: Immune functions and immunopathology of palatine and nasopharyngeal tonsils. In: Immunology of the Ear. Raven Press, New York, pp63-106, 1987.
3. Felten SY, Felten DL, Bellinger DL and Olschowka JA: Noradrenergic and peptidergic innervation od lymphoid organs. Chem Immunol 52: 25-48, 1992.
4. Lewin GR and Barde YA: Physiology of neurotrophins. Ann Rev Neurosci 9: 217-289, 1996.
5. Barbacid M: The TrK family of neurotrophin receptors. J Neuroimmunol 25: 1386-1403, 1994.
6. Kaplan DR and Miller FD: Signal transduction by the neurotrophin receptors. Curr Opin Cell Biol 9: 213-221, 1997.
7. Lomen HC and Shooter EM: Widespread neurotrophin receptor expression in the immune system and other non-neuronal rat tissue. J Neurochem 64: 1780-1789, 1995.
8. Lommatzsch M, Braun A, Mannsfeldt A, Botchkarev VA, Botchkareva NV, Paus R, Fischer A, Lewin GR and Renz H: Abundant production of brain-derived neurotrophic factor by adult visceral epithelia implications for paracrine and target-derived neurotrophic functions. Am J Pathol 155: 1183-1193, 1999.
9. Snider WD: Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77: 627-638, 1994.
10. Otten U and Gadient RA: Neurotrophins and cytokines-intermediaries between the immune and nervous systems. Int J Dev Neurosci 13: 147-151, 1995.
11. Tessarollo L: Pleiotropic functions of neurotrophins in development. Cytokine Growth Factor Rev 9: 125-137, 1998.
12. Aloe L, Simone MD and Properzi F: Nerve growth factor: a neurotrophin with activity on cells of the immune system. Microsc Res Tech 45: 285-291, 1999.
13. Aloe L: Nerve growth factor and neuroimmune responses: basic and clinical observations. Arch Physiol Biochem 109: 336-354, 2001.
14. Sariola H: The neurotrophic factors in non-neuronal tissues. Cell Mol Life Sci 58: 1061-1066, 2001.
15. Carlson SL, Albers KM, Beiting DJ, Parish M, Conner JM and Davis BM: NGF modulates sympathetic innervation of lymphoid tissues. J Neurosci 15: 5892-5899, 1995.
16. Carlson SL, Johnson S, Parrish ME and Cass WA: Development of immune hyperinnervation in NGF-transgenic mice. Exp Neurol 149: 209-220, 1998.
17. Yaeger MJ, Koestner A, Marushige K and Marushige Y: The reverse transforming effects of nerve growth factor on five human neurogenic tumor cell lines: in vitro results. Acta Neuropathol (Berl) 83: 72-80, 1991.
18. Sala R, Viegi A, Rossi FM, Pizzorusso T, Bonanno G, Raiteri M and Maffei L: Nerve growth factor and brain derived neurotrophic factor increase neurotransmitter release in the rat visual cortex. Eur J Neurosci 10: 2185-2191, 1998.
19. Vega JA, Garcia-Suarez O, Hannestad J, Perez-Perez M and Germana A: Neurotrophins and the immune system. J Anat 203: 1-19, 2003.
20. Ciriaco E, Dall'Aglio C, Hannestad J, Huerta JJ, Laura R, Germana G and Vega JA: Localization of TrK neurotrophin receptor-like proteins in avian primary lymphoid organs (thymus and bursa of Fabricius). J Neuroimmunol 69: 73-78, 1996.
21. Hannestad J, Levanti B and Vega JA: Distribution of neurotrophin receptors in human palatine tonsils: an immunohistochemical study. J Neuroimmunol 58: 131-137, 1995.
22. Garcia-Suarez O, Hannestad J, Esteban I, Martinez del Valle M, Naves FJ and Vega JA: Neurotrophin receptor-like protein immunoreactivity in human lymph nodes. Anat Rec 249: 226-232, 1997.
23. Labouyrie E, Parrens M, De Mascarel A, Bloch B and Merlio JP: Distribution of NGF receptors in normal and pathologic human lymphoid tissues. J Neuroimmunol 77: 161-173, 1997.
24. Dean DH, Hiramoto RN and Ghanta VK: Modulation of immune response. A possible role for murine salivary epidermal and nerve growth factors. J Periodontol 58: 498-500, 1987.
25. Kerschensteiner M, Gallmeier E, Behrens L, Leal VV, Misgeld T, Klinkert WE, Kolbeck R, Hoppe E, Oropeza-Wekerle RL, Bartke I, Stadelmann C, Lassmann H, Wekerle H and Hohlfeld R: Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 189: 865-870, 1999.
26. Moalem G, Gdalyahu A, Shani Y, Otten U, Lavarovici P, Cohen IR and Schwartz M: Production of neurotrophins by activated T cells: implications for neuroprotective role autoimmunity. J Autoimmun 15: 331-345, 2000.
27. Ehrhard PB, Erb P, Graumann U and Otten U: Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated Cd4-positive T-cell clones. Proc Natl Acad Sci USA 90: 10984-10988, 1993.
28. Santambrogio L, Benedetti M, Chao MV, Muzaffar R, Kulig K, Gabellini N and Hochwald G: Nerve growth factor production by lymphocytes. J Immunol 153: 4488-4495, 1994.
29. Lambiase A, Bracci-Laudiero L, Bonini S, Bonini S, Starace G, D'Elios MM, De Carli M and Aloe L: Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors. J Allergy Clin Immunol 100: 408-414, 1997.
30. Besser M and Wank R: Cuuting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors. J Immunol 1162: 6303-6306, 1999.
31. Kittur SD, Song L, Endo H and Adler WH: Nerve growth factor receptor gene expression in human peripheral blood lymphocytes in aging. J Neurosci Res 32: 444-448, 1992.
32. Otten U, Ehrhard P and Peck R: Nerve growth factor induces growth and differentiation of human B lymphocytes. Proc Natl Acad Sci USA 86: 10059-10063, 1998.
33. Torcia M, Bracci-Laudierio L, Lucibello M, Nencioni L, Labardi D, Rubartelli A, Cozzolino F, Aloe L and Garaci E: Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Cell 85: 345-356, 1996.
34. Melamed I, Kelleher CA, Franklin RA, Brodie C, Hempstead B, Kaplan D and Gelfand EW: Nerve growth factor signal transduction in human B lymphocytes is mediated by gp140Trk. Eur J Immunol 26: 1985-1992, 1996.
35. D'Onofrio M, De Grazia U, Morrone S, Cuomo L, Spinsanti P, Frati L, Gulino A and Ragona G: Expression of neurotrophin receptors in normal and malignant B lymphocytes. Eur Cytokine Netw 11: 283-291, 2000.
36. Brodie C, Oshiba A, Renz H, Bradley K and Gelfand EW: Nerve growth-factor and anti-CD40 provide opposite signals for the production of IgE in interleukin-4-treated lymphocytes. Eur J Immunol 26: 171-178, 1996.
37. Schenone A, Gill JS, Zacharias DA and Windebank AJ: Expression of high- and low- affinity neurotrophin receptors on human transformed B lymphocytes. J Neuroimmunol 64: 141-149, 1996.
38. Hellings P, Jorissen M and Ceuppens JL: The Waldeyer's Ring. Acta Otorhinolaryngol (Belg) 54: 237-241, 2000.
39. Bonini S, Lambiase A, Angelucci F, Magrini L and Aloe L: Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma. Proc Natl Acad Sci USA 93: 10995-10960, 1996.
40. De Vries A, Engels F, Henricks PA, Leusink-Muis T, Fischer A and Nijkamp FP: Antibodies directed against nerve growth factor inhibit the acute bronchoconstriction due to allergen challenge in guinea-pigs. Clin Exp Allergy 32: 325-328, 2002.
41. Susaki Y, Shimizu S, Katakura K and Watanabe N: Functional properties of murine macrophages promoted by nerve growth factor. Blood 88: 4630-4637, 1996.
42. Porcheray F and Gras G: Neurotrophins modulate monocyte chemotaxis without affecting macrophage function. Clin Exp Immunol 151: 476-486, 2008.
43. Barouch R, Appel E, Kazimirsky G and Brodie C: Macrophages express neurotrophins and neurotrophin receptors: regulation of nitric oxide production by NT-3. J Immunol 112: 72-77, 2001.
44. Caroleo MC, Costa N, Bracci-Laudiero L and Aloe L: Human monocytes/ macrophages activated by exposure to LPS overexpress NGF and NGF receptors. J Immunol 113: 193-201, 2001.
45. Pezzati P, Stanisz AM, Marshall JS, Bienenstock J and Stead RH: Expression of nerve growth factor receptor immuno-reactivity on follicular dendritic cells from human mucosa associated lymphoid tissues. Immunology 76: 485-490, 1992.
46. Bronzetti E, Artico M, Lo Vasco VR, Felici LM, Bosco S, Magliulo G, Pompili E and Fumagalli L: Expression of neurotransmitters and neurotrophins in human adenoid tissue. Int J Mol Med 15: 921-928, 2005.
47. Bronzetti E, Artico M, Pompili E, Felici LM, Stringaro A, Bosco S, Magliulo G, Colone M, Arancia G, Vitale M and Fumagalli L: Neurotrophins and neurotransmitters in human palatine tonsils: an immunohistochemical and RT-PCR analysis. Int J Mol Med 18: 49-58, 2006.
48. Stanisz AM and Stanisz JA: Nerve growth factor and neuroimmune interactions in inflammatory diseases. Ann NY Acad Sci 917: 268-272, 2000.
49. Bayas A, Kruse N, Moriabadi NF, Weber F, Hummel V, Wohleben G, Gold R, Toyka KV and Rieckmann P: Modulation of cytokine mRNA expression by brain-derived neurotrophic factor and berve growth factor in human immune cells. Neurosci Lett 335: 155-158, 2003.