Do fatty acids help in overcoming reading difficulties? A double-blind, placebo-controlled study of the effects of eicosapentaenoic acid and carnosine supplementation on children with dyslexia

Child: Care, Health and Development

Volumn 35, Issue 1, 2009, Pages 112-119

  Kairaluoma, Leila ^a   Narhi V ^b   Ahonen, T ^a   Westerholm, J ^b   Aro, M ^b  

^a UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^b Niilo Maki Instituutti   (Finland)

Author keywords

Dyslexia; Ethyl EPA; Fatty acids; Intervention

Indexed keywords

5,8,11,14,17 ICOSAPENTAENOIC ACID; CARNOSINE; CELLULOSE; PLACEBO; TRIACYLGLYCEROL;

ACADEMIC ACHIEVEMENT; ACCURACY; ARITHMETIC; ARTICLE; ATTENTION DISTURBANCE; BEHAVIOR DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DYSLEXIA; FEMALE; GENDER; HUMAN; INTELLIGENCE; LANGUAGE ABILITY; LINGUISTICS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; READING; SCHOOL CHILD; SPECIAL EDUCATION; SPELLING; TREATMENT RESPONSE;

CARNOSINE; CASE-CONTROL STUDIES; CHILD; COMBINED MODALITY THERAPY; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DYSLEXIA; EICOSAPENTAENOIC ACID; FEMALE; FINLAND; HUMANS; MALE; TREATMENT OUTCOME;

EID: 58149327285     PISSN: 03051862     EISSN: 13652214     Source Type: Journal    
DOI: 10.1111/j.1365-2214.2008.00881.x     Document Type: Article

References (37)

1. Achenbach, T. (1991) Manual for the Teacher's Report Form and 1991 Profile. University of Vermont Department of Psychiatry, Burlington, USA.
2. Ahonen, T., Tuovinen, S. & Leppäsaari, T. (1999) Nopean Sarjallisen Nimeämisen Testi [A Test of Rapid Serial Naming], Haukkaranta school and Niilo Mäki Institute, Lievestuore, Finland.
3. Alexander, A. W. & Slinger-Constant, A. M. (2004) Current status of treatments for dyslexia: Critical review. Journal of Child Neurology, 19, 744-758.
4. Baker, S. (1985) A biochemical approach to the problem of dyslexia. Journal of Learning Disabilities, 18, 581-584.
5. Bradley, L. & Bryant, P. (1985) Rhyme and Reason in Reading and Spelling. University of Michigan Press, Ann Arbor, MI, USA.
6. Chard, D. J., Vaughn, S. & Tyler, B.-J. (2002) A synthesis of research on effective interventions for building reading fluency with elementary students with learning disabilities. Journal of Learning Disabilities, 35, 386-406.
7. Chez, M. G., Buchanan, C. P., Aimonovitch, M. C., Becker, M., Schaefer, K., Black, C. & Komen, J. (2002) Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders. Journal of Child Neurology, 17, 833-837.
8. Cyhlarova, E., Bell, J. G., Dick, J. R., Mackinley, E. E., Stein, J. F. & Richardson, A. J. (2007) Membrane fatty acids, reading and spelling in dyslexic and non-dyslexic adults. European Neuropsychopharmacology, 17, 116-121.
9. Denckla, M. B. & Rudel, R. (1974) Rapid 'automatized' naming of pictured objects, colors, letters and numbers by normal children. Cortex, 10, 186-202.
10. Denckla, M. B. & Rudel, R. G. (1976) Naming of object-drawings by dyslexic and other learning disabled children. Brain & Language, 3, 1-15.
11. Gathercole, S. E. & Baddeley, A. D. (1993) Working memory and language. Lawrence Erlbaum Associates, Hove, UK.
12. Goodman, R. (1997) The strengths and difficulties questionnaire: A research note. Journal of Child Psychology and Psychiatry, 38, 581-586.
13. Häyrinen, T., Serenius-Sirve, S. & Korkman, M. (1999) Reading and Writing Test Designed for and Normalized in Finnish Elementary School. Psykologien Kustannus, Helsinki, Finland.
14. Korkman, M., Kirk, U. & Kemp, S. (1997) Nepsy. A Developmental Neuropsychological Assessment. Psykologien Kustannus Oy, Helsinki, Finland.
15. Laasonen, M., Erkkilä, A. T., Isotalo, E., Pulkkinen, J. J., Haapanen, M.-L. & Virsu, V. (2006) Serum lipid fatty acids, phonological processing, and reading in children with oral clefts. Prostaglandins, Leukotriens and Essential Fatty Acids, 74, 7-16.
16. Lindeman, J. (1998) Ala-asteen lukutesti, ALLU. [Reading test for primary school]. Centre for Learning Research, University of Turku, Jyväskylä, Finland.
17. Lyon, G. R., Shaywitz, S. E. & Shaywitz, B. A. (2003) A definition of dyslexia. Annals of Dyslexia, 53, 1-14.
18. Mann, V. A. & Liberman, I. Y. (1984) Phonological awareness and verbal short-term memory. Journal of Learning Disabilities, 17, 592-599.
19. Niilo Mäki Institute (1992) Neuropsychological and Achievement Tests: Local Normative Data for Niilo Mäki Institute-Test Battery-Revised. Author, Jyväskylä, Finland.
20. Nopola-Hemmi, J., Taipale, M., Haltia, T., Lehesjoki, A. E., Voutilainen, A. & Kere, J. (2000) Two translocations of chromosome 15q associated with dyslexia. Journal of Medical Genetics, 37, 771-775.
21. Parker, G., Gibson, N. A., Brotchie, H., Heruc, G., Rees, A. M. & Hadzi-Pavlovic, D. (2006) Omega-3 fatty acids and mood disorders. American Journal of Psychiatry, 6, 969-978.
22. Richardson, A. J. (2004) Clinical trials of fatty acid treatment in ADHD, dyslexia, dyspraxia and the autistic spectrum. Prostaglandins Leukot Essent Fatty Acids, 70, 383-390.
23. Richardson, A.J. (2006) Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. International Review of Psychiatry, 18, 155-172.
24. Richardson, A. J. & Montgomery, P. (2005) The Oxford-Durham study: A randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics, 115, 1360-1366.
25. Richardson, A. J. & Puri, B. K. (2002) A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharmacol Biol Psychiatry, 26, 233-239.
26. Richardson, A. J. & Ross, M. A. (2000) Fatty acid metabolism in neurodevelopmental disorder: A new perspective on associations between attention-deficit/hyperactivity disorder, dyslexia, dyspraxia and the autistic spectrum. Prostaglandins Leukot Essent Fatty Acids, 63, 1-9.
27. Richardson, A. J., Calvin, C. M., Clisby, C., Schoenheimer, D. R., Montgomery, P., Hall, J. A., Hebb, G., Westwood, E., Talcott, J. B. & Stein, J. F. (2000) Fatty acid deficiency signs predict the severity of reading and related difficulties in dyslexic children. Prostaglandins Leukot Essent Fatty Acids, 63, 69-74.
28. Räsänen, P. (2004) RMAT Laskutaidon Testi.9-12-Vuotiaille. Niilo Mäki Institute, Jyväskylä, Finland.
29. Scanlon, D., Vellutino, F., Small, S., Fanuele, D. & Sweeney, J. (2005) Severe reading difficulties - can tehy be prevented? A comparison of prevention and intervention approaches. Exceptionality, 13, 209-227.
30. Schatschneider, C. & Torgesen, J. (2004) Using our current understanding of dyslexia to support early identification and intervention. Journal of Child Neurology, 19, 759-765.
31. Spring, C. & Capps, C. (1974) Encoding speed, rehearsal, and probed recall of dyslexic boys. Journal of Educational Psychology, 66, 780-786.
32. Stein, J. (2000) The neurobiology of reading difficulties. Prostaglandins Leukot Essent Fatty Acids, 63, 109-116.
33. Stein, J. & Walsh, V. (1997) To see but not to read; the magnocellular theory of dyslexia. Trends in Neurosciences, 20, 147-152.
34. Wagner, R. K. & Torgesen, J. K. (1987) The nature of phonological processing and its causal role in the acquisition of reading skills. Psychological Bulletin, 101, 192-212.
35. Wechsler, D. (1991) Wechsler Intelligence Scale for Children. The Psychological Corporation, San Antonio, TX, USA.
36. Wimmer, H., Mayringer, H. & Landerl, K. (2000) The double-deficit hypothesis and difficulties in learning to read a regular orthography. Journal of Educational Psychology, 92, 668-680.
37. Wolf, M. & Obregon, M. (1992) Early naming deficits, developmental dyslexia, and a specific deficit hypothesis. Brain & Language, 42, 219-247.