The apical uptake transporter of levofloxacin is distinct from the peptide transporter in human intestinal epithelial Caco-2 cells

Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 5, 2008, Pages 373-378

  Fukumori, Shiro ^a   Murata, Toshiya ^a   Takaai, Mari ^a   Tahara, Katsutoshi ^a   Taguchi, Masato ^a   Hashimoto, Yukiya ^a,b  

^a UNIVERSITY OF TOYAMA   (Japan)

^b NONE   (Japan)

Author keywords

Caco 2 cells; Glycylsarcosine; Levofloxacin; OATP; Peptide transporter

Indexed keywords

CARNITINE; CEFALEXIN; ENALAPRIL; ERYTHROMYCIN; FEXOFENADINE; GLYCYLSARCOSINE; IMIPRAMINE; INOSINE; LEVOFLOXACIN; MIZORIBINE; NICOTINE; ORGANIC ANION TRANSPORTER; PENICILLIN G; PEPTIDE TRANSPORTER 1; RIBAVIRIN; RIFAMPICIN; VALACICLOVIR; ZIDOVUDINE; CARRIER PROTEIN; COTRANSPORTER; DIPEPTIDE; INTESTINAL PEPTIDE PROTON COTRANSPORTER; INTESTINAL PEPTIDE-PROTON COTRANSPORTER; LOMEFLOXACIN; OFLOXACIN; QUINOLONE DERIVATIVE; SLC15A1 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL STRAIN CACO 2; CELL TRANSPORT; CONTROLLED STUDY; DRUG ABSORPTION; DRUG TRANSPORT; HUMAN; HUMAN CELL; CELL COMPARTMENTALIZATION; DRUG EFFECT; INTESTINE ABSORPTION; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL COMPARTMENTATION; DIPEPTIDES; FLUOROQUINOLONES; HUMANS; INTESTINAL ABSORPTION; MEMBRANE TRANSPORT PROTEINS; OFLOXACIN; SYMPORTERS;

EID: 58149291936     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.23.373     Document Type: Article

References (9)

1. Maeda, T., Takahashi, K.,Ohtsu, N., Oguma, T., Ohnishi, T., Atsumi, R. and Tamai, I.: Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol. Pharm., 4: 85-94 (2007).
2. Yamaguchi, H., Yano, I., Saito, H. and Inui, K.: Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2. Eur. J. Pharmacol., 431: 297-303 (2001).
3. Takaai, M., Suzuki, H., Ishida, K., Tahara, K. and Hashimoto, Y.: Pharmacokinetic analysis of transcellular transport of levofloxacin across LLC-PK1 and Caco-2 cell monolayers. Biol. Pharm. Bull., 30: 2167-2172 (2007).
4. Irie, M., Terada, T., Tsuda, M., Katsura, T. and Inui, K.: Prediction of glycylsarcosine transport in Caco-2 cell lines expressing PEPT1 at different levels. Pflugers. Arch., 452: 64-70 (2006).
5. Rabbaa, L., Dautrey, S., Colas-Linhart, N., Carbon, C. and Farinotti, R.: Absorption of ofloxacin isomers in the rat small intestine. Antimicrob. Agents Chemother., 41: 2274-2277 (1997).
6. Yamaguchi, T., Yokogawa, M., Sekine, Y. and Hashimoto, M.: Intestinal absorption characteristics of sparfloxacin. Xenobiot. Metab. Dispos., 6: 53-59 (1991).
7. Ishida, K., Takaai, M. and Hashimoto, Y.: Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells. Biol. Pharm. Bull., 29: 522-526 (2006).
8. Irie, M., Terada, T., Okuda, M. and Inui, K.: Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2. Pflugers. Arch., 449: 186-194 (2004).
9. Hirano, T., Yasuda, S., Osaka, Y., Kobayashi, M., Itagaki, S. and Iseki, K.: Mechanism of the inhibitory effect of zwitterionic drugs (levofloxacin and grepafloxacin) on carnitine transporter (OCTN2) in Caco-2 cells. Biochim. Biophys. Acta., 1758: 1743-1750 (2006).