메뉴 건너뛰기




Volumn 42, Issue 2, 2009, Pages 100-108

Nutrient distribution and metabolism in the intervertebral disc in the unloaded state: A parametric study

Author keywords

Cell nutrition; Intervertebral disc degeneration; Nutrient diffusion; Osmomechanical behavior; Quadriphasic theory

Indexed keywords

A PLANES; CELLULAR METABOLISMS; COUPLED MODELS; DIFFUSION COEFFICIENTS; DISC DEGENERATIONS; ENDPLATE; EQUILIBRIUM STATES; EXTRACELLULAR MATRIXES; FINITE ELEMENT MODELS; GLUCOSE CONCENTRATIONS; INTERVERTEBRAL DISC DEGENERATION; INTERVERTEBRAL DISCS; MAIN FACTORS; NUMERICAL SIMULATIONS; NUTRIENT DIFFUSION; NUTRIENT DISTRIBUTIONS; OSMOMECHANICAL BEHAVIOR; OSMOTIC POWERS; PARAMETRIC STUDIES; PHYSIOLOGICAL CONDITIONS; PROTEOGLYCAN; PROTEOGLYCANS; QUADRIPHASIC THEORY; REST PERIODS; SOLUTE DISTRIBUTIONS; UNLOADED STATES;

EID: 58149289689     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2008.10.034     Document Type: Article
Times cited : (48)

References (46)
  • 1
    • 0029813162 scopus 로고    scopus 로고
    • The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration
    • Antoniou J., Steffen T., Nelson F., Winterbottom N., Hollander A.P., Poole R.A., Aebi M., and Alini M. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. Journal of Clinical Investigation 98 (1996) 996-1003
    • (1996) Journal of Clinical Investigation , vol.98 , pp. 996-1003
    • Antoniou, J.1    Steffen, T.2    Nelson, F.3    Winterbottom, N.4    Hollander, A.P.5    Poole, R.A.6    Aebi, M.7    Alini, M.8
  • 2
    • 18044402384 scopus 로고    scopus 로고
    • Elevated synthetic activity in the convex side of scoliotic intervertebral discs and endplates compared with normal tissues
    • Antoniou J., Arlet V., Goswami T., Aebi M., and Alini M. Elevated synthetic activity in the convex side of scoliotic intervertebral discs and endplates compared with normal tissues. Spine 26 (2001) E198-E206
    • (2001) Spine , vol.26
    • Antoniou, J.1    Arlet, V.2    Goswami, T.3    Aebi, M.4    Alini, M.5
  • 3
    • 0031908754 scopus 로고    scopus 로고
    • Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain
    • Bartels E.M., Fairbank J.C., Winlove C.P., and Urban J.P. Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain. Spine 23 (1998) 1-8
    • (1998) Spine , vol.23 , pp. 1-8
    • Bartels, E.M.1    Fairbank, J.C.2    Winlove, C.P.3    Urban, J.P.4
  • 4
    • 0028117251 scopus 로고
    • Compressive mechanical properties of the human anulus fibrosus and their relationship to biochemical composition
    • Best B.A., Guilak F., Setton L.A., Zhu W., Saed-Nejad F., Ratcliffe A., Weidenbaum M., and Mow V.C. Compressive mechanical properties of the human anulus fibrosus and their relationship to biochemical composition. Spine 19 (1994) 212-221
    • (1994) Spine , vol.19 , pp. 212-221
    • Best, B.A.1    Guilak, F.2    Setton, L.A.3    Zhu, W.4    Saed-Nejad, F.5    Ratcliffe, A.6    Weidenbaum, M.7    Mow, V.C.8
  • 5
    • 10444232467 scopus 로고    scopus 로고
    • Effect of nutrient deprivation on the viability of intervertebral disc cells
    • Bibby S.R.S., and Urban J.P.G. Effect of nutrient deprivation on the viability of intervertebral disc cells. European Spine Journal 13 (2004) 695-701
    • (2004) European Spine Journal , vol.13 , pp. 695-701
    • Bibby, S.R.S.1    Urban, J.P.G.2
  • 6
    • 0037108786 scopus 로고    scopus 로고
    • Cell viability in scoliotic discs in relation to disc deformity and nutrient levels
    • Bibby S.R.S., Fairbank J.C.T., Urban M.R., and Urban J.P.G. Cell viability in scoliotic discs in relation to disc deformity and nutrient levels. Spine 27 (2002) 2220-2228
    • (2002) Spine , vol.27 , pp. 2220-2228
    • Bibby, S.R.S.1    Fairbank, J.C.T.2    Urban, M.R.3    Urban, J.P.G.4
  • 7
    • 14344255879 scopus 로고    scopus 로고
    • Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells
    • Bibby S.R.S., Jones D.A., Ripley R.M., and Urban J.P.G. Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells. Spine 30 (2005) 487-496
    • (2005) Spine , vol.30 , pp. 487-496
    • Bibby, S.R.S.1    Jones, D.A.2    Ripley, R.M.3    Urban, J.P.G.4
  • 8
    • 0027164987 scopus 로고
    • Quantitative MR imaging of lumbar intervertebral disks and vertebral bodies: influence of diurnal water content variations
    • Boos N., Wallin A., Gbedegbegnon T., Aebi M., and Boesch C. Quantitative MR imaging of lumbar intervertebral disks and vertebral bodies: influence of diurnal water content variations. Radiology 188 (1993) 351-354
    • (1993) Radiology , vol.188 , pp. 351-354
    • Boos, N.1    Wallin, A.2    Gbedegbegnon, T.3    Aebi, M.4    Boesch, C.5
  • 9
    • 33750619084 scopus 로고    scopus 로고
    • Monitoring of metabolite gradients in tissue-engineered constructs
    • Boubriak O.A., Urban J.P.G., and Cui Z. Monitoring of metabolite gradients in tissue-engineered constructs. Journal of the Royal Society 3 (2006) 637-648
    • (2006) Journal of the Royal Society , vol.3 , pp. 637-648
    • Boubriak, O.A.1    Urban, J.P.G.2    Cui, Z.3
  • 10
    • 0000329060 scopus 로고
    • Paths of nutrition in articular cartilage and intervertebral discs
    • Brodin H. Paths of nutrition in articular cartilage and intervertebral discs. Acta Orthopaedica Scandinavica 24 (1955) 177-183
    • (1955) Acta Orthopaedica Scandinavica , vol.24 , pp. 177-183
    • Brodin, H.1
  • 11
    • 0141646549 scopus 로고    scopus 로고
    • Biomechanical responses of the intervertebral joints to static and vibrational loading: a finite element study
    • Cheung J.T., Zhang M., and Chow D.H. Biomechanical responses of the intervertebral joints to static and vibrational loading: a finite element study. Clinical Biomechanics 18 (2003) 790-799
    • (2003) Clinical Biomechanics , vol.18 , pp. 790-799
    • Cheung, J.T.1    Zhang, M.2    Chow, D.H.3
  • 14
    • 0032055960 scopus 로고    scopus 로고
    • Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls
    • Gruber H.E., and Hanley E.N.J. Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls. Spine 23 (1998) 751-757
    • (1998) Spine , vol.23 , pp. 751-757
    • Gruber, H.E.1    Hanley, E.N.J.2
  • 16
    • 41549167595 scopus 로고    scopus 로고
    • Effects of mechanical compression on metabolism and distribution of oxygen and lactate in intervertebral disc
    • Huang C., and Gu W.Y. Effects of mechanical compression on metabolism and distribution of oxygen and lactate in intervertebral disc. Journal of Biomechanics 41 (2008) 1184-1196
    • (2008) Journal of Biomechanics , vol.41 , pp. 1184-1196
    • Huang, C.1    Gu, W.Y.2
  • 20
    • 29444439073 scopus 로고    scopus 로고
    • Effects of degeneration on the biphasic material properties of human nucleus pulposus in confined compression
    • Johannessen W., and Elliott D.M. Effects of degeneration on the biphasic material properties of human nucleus pulposus in confined compression. Spine 30 (2005) E724-E729
    • (2005) Spine , vol.30
    • Johannessen, W.1    Elliott, D.M.2
  • 22
    • 0035581164 scopus 로고    scopus 로고
    • Lumbar spine disc height and curvature responses to an axial load generated by a compression device compatible with magnetic resonance imaging
    • Kimura S., Steinbach G.C., Watenpaugh D.E., and Hargens A.R. Lumbar spine disc height and curvature responses to an axial load generated by a compression device compatible with magnetic resonance imaging. Spine 26 (2001) 2596-2600
    • (2001) Spine , vol.26 , pp. 2596-2600
    • Kimura, S.1    Steinbach, G.C.2    Watenpaugh, D.E.3    Hargens, A.R.4
  • 25
    • 0346279916 scopus 로고    scopus 로고
    • Articular cartilage with intra- and extrafibrillar waters: a chemo-mechanical model
    • Loret B., and Simões F.M.S. Articular cartilage with intra- and extrafibrillar waters: a chemo-mechanical model. Mechanics of Materials 36 (2004) 515-541
    • (2004) Mechanics of Materials , vol.36 , pp. 515-541
    • Loret, B.1    Simões, F.M.S.2
  • 27
    • 0001954556 scopus 로고
    • Nutrition and metabolism of the intervertebral disc
    • Ghosh P. (Ed), CRC Press, Boca Raton, FL
    • Maroudas A. Nutrition and metabolism of the intervertebral disc. In: Ghosh P. (Ed). The Biology of the Intervertebral Disc (1988), CRC Press, Boca Raton, FL 1-37
    • (1988) The Biology of the Intervertebral Disc , pp. 1-37
    • Maroudas, A.1
  • 28
    • 0016752270 scopus 로고
    • Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro
    • Maroudas A., Stockwell R.A., Nachemson A., and Urban J. Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. Journal of Anatomy 120 (1975) 113-130
    • (1975) Journal of Anatomy , vol.120 , pp. 113-130
    • Maroudas, A.1    Stockwell, R.A.2    Nachemson, A.3    Urban, J.4
  • 29
    • 1842355772 scopus 로고
    • Lumbar intradiscal pressure. Experimental studies on post-mortem material
    • Nachemson A. Lumbar intradiscal pressure. Experimental studies on post-mortem material. Acta Orthopaedica Scandinavica 43 Supplementum (1960) 1-104
    • (1960) Acta Orthopaedica Scandinavica , vol.43 , Issue.Supplementum , pp. 1-104
    • Nachemson, A.1
  • 30
    • 0026189257 scopus 로고
    • Electrochemical method for direct measurement of oxygen concentration and diffusivity in the intervertebral disc: electrochemical characterization and tissue-sensor interactions
    • O'Hare D., Winlove C.P., and Parker K.H. Electrochemical method for direct measurement of oxygen concentration and diffusivity in the intervertebral disc: electrochemical characterization and tissue-sensor interactions. Journal of Biomedical Engineering 13 (1991) 304-312
    • (1991) Journal of Biomedical Engineering , vol.13 , pp. 304-312
    • O'Hare, D.1    Winlove, C.P.2    Parker, K.H.3
  • 31
    • 0026700749 scopus 로고
    • The effect of lactate and pH on proteoglycan and protein synthesis rates in the intervertebral disc
    • Ohshima H., and Urban J.P. The effect of lactate and pH on proteoglycan and protein synthesis rates in the intervertebral disc. Spine 17 (1992) 1079-1082
    • (1992) Spine , vol.17 , pp. 1079-1082
    • Ohshima, H.1    Urban, J.P.2
  • 34
    • 0042335652 scopus 로고    scopus 로고
    • Finite element study of nutrient diffusion in the human intervertebral disc
    • Sélard E., Shirazi-Adl A., and Urban J.P.G. Finite element study of nutrient diffusion in the human intervertebral disc. Spine 28 (2003) 1945-1953
    • (2003) Spine , vol.28 , pp. 1945-1953
    • Sélard, E.1    Shirazi-Adl, A.2    Urban, J.P.G.3
  • 35
    • 30344483976 scopus 로고    scopus 로고
    • Analysis of nonlinear coupled diffusion of oxygen and lactic acid in intervertebral discs
    • Soukane D.M., Shirazi-Adl A., and Urban J.P.G. Analysis of nonlinear coupled diffusion of oxygen and lactic acid in intervertebral discs. Journal of Biomechanical Engineering 127 (2005) 1121-1126
    • (2005) Journal of Biomechanical Engineering , vol.127 , pp. 1121-1126
    • Soukane, D.M.1    Shirazi-Adl, A.2    Urban, J.P.G.3
  • 36
    • 34547763262 scopus 로고    scopus 로고
    • Computation of coupled diffusion of oxygen, glucose and lactic acid in an intervertebral disc
    • Soukane D.M., Shirazi-Adl A., and Urban J.P.G. Computation of coupled diffusion of oxygen, glucose and lactic acid in an intervertebral disc. Journal of Biomechanics 40 (2007) 2645-2654
    • (2007) Journal of Biomechanics , vol.40 , pp. 2645-2654
    • Soukane, D.M.1    Shirazi-Adl, A.2    Urban, J.P.G.3
  • 37
    • 0000779366 scopus 로고    scopus 로고
    • A mixed finite element formulation of triphasic mechano-electrochemical theory for charged, hydrated biological soft tissues
    • Sun D.N., Gu W.Y., Guo X.E., Lai W.M., and Mow V.C. A mixed finite element formulation of triphasic mechano-electrochemical theory for charged, hydrated biological soft tissues. International Journal for Numerical Methods in Engineering 45 (1999) 1375-1402
    • (1999) International Journal for Numerical Methods in Engineering , vol.45 , pp. 1375-1402
    • Sun, D.N.1    Gu, W.Y.2    Guo, X.E.3    Lai, W.M.4    Mow, V.C.5
  • 38
    • 0025332891 scopus 로고
    • Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc
    • Thompson J.P., Pearce R.H., Schechter M.T., Adams M.E., Tsang I.K., and Bishop P.B. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine 15 (1990) 411-415
    • (1990) Spine , vol.15 , pp. 411-415
    • Thompson, J.P.1    Pearce, R.H.2    Schechter, M.T.3    Adams, M.E.4    Tsang, I.K.5    Bishop, P.B.6
  • 39
    • 0021894505 scopus 로고
    • Swelling pressure of the inervertebral disc: influence of proteoglycan and collagen contents
    • Urban J.P., and McMullin J.F. Swelling pressure of the inervertebral disc: influence of proteoglycan and collagen contents. Biorheology 22 (1985) 145-157
    • (1985) Biorheology , vol.22 , pp. 145-157
    • Urban, J.P.1    McMullin, J.F.2
  • 40
    • 0018567349 scopus 로고
    • Swelling pressures of proteoglycans at the concentrations found in cartilaginous tissues
    • Urban J.P., Maroudas A., Bayliss M.T., and Dillon J. Swelling pressures of proteoglycans at the concentrations found in cartilaginous tissues. Biorheology 16 (1979) 447-464
    • (1979) Biorheology , vol.16 , pp. 447-464
    • Urban, J.P.1    Maroudas, A.2    Bayliss, M.T.3    Dillon, J.4
  • 42
    • 0034879405 scopus 로고    scopus 로고
    • Parametric finite element analysis of vertebral bodies affected by tumors
    • Whyne C.M., Hu S.S., and Lotz J.C. Parametric finite element analysis of vertebral bodies affected by tumors. Journal of Biomechanics 34 (2001) 1317-1324
    • (2001) Journal of Biomechanics , vol.34 , pp. 1317-1324
    • Whyne, C.M.1    Hu, S.S.2    Lotz, J.C.3
  • 44
    • 0033560829 scopus 로고    scopus 로고
    • New in vivo measurements of pressures in the intervertebral disc in daily life
    • Wilke H.J., Neef P., Caimi M., Hoogland T., and Claes L.E. New in vivo measurements of pressures in the intervertebral disc in daily life. Spine 24 (1999) 755-762
    • (1999) Spine , vol.24 , pp. 755-762
    • Wilke, H.J.1    Neef, P.2    Caimi, M.3    Hoogland, T.4    Claes, L.E.5
  • 46
    • 34249650771 scopus 로고    scopus 로고
    • Three-dimensional inhomogeneous triphasic finite-element analysis of physical signals and solute transport in human intervertebral disc under axial compression
    • Yao H., and Gu W.Y. Three-dimensional inhomogeneous triphasic finite-element analysis of physical signals and solute transport in human intervertebral disc under axial compression. Journal of Biomechanics 40 (2007) 2071-2077
    • (2007) Journal of Biomechanics , vol.40 , pp. 2071-2077
    • Yao, H.1    Gu, W.Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.