Effects of mechanical compression on metabolism and distribution of oxygen and lactate in intervertebral disc

Journal of Biomechanics

Volumn 41, Issue 6, 2008, Pages 1184-1196

  Huang, Chun Yuh ^a   Gu, Wei Yong ^b  

^a NOVA SOUTHEASTERN UNIVERSITY   (United States)

^b University of Miami College of Engineering   (United States)

Author keywords

Computational biomechanics; Finite element method; Glucose; Mixture theory; Soft tissue mechanics; Transport

Indexed keywords

BIOMECHANICS; COMPUTATIONAL MECHANICS; FINITE ELEMENT METHOD; NUTRIENTS; OXYGEN; TISSUE;

INTERVERTEBRAL DISC; MIXTURE THEORY; SOFT TISSUE MECHANICS;

METABOLISM;

LACTIC ACID; OXYGEN;

ARTICLE; CELL METABOLISM; COMPRESSION; INTERVERTEBRAL DISK; NUTRIENT DYNAMICS; OXYGEN CONSUMPTION; OXYGEN TENSION; OXYGEN TRANSPORT; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SYNTHESIS;

HYDROGEN-ION CONCENTRATION; INTERVERTEBRAL DISK; LACTIC ACID; LUMBAR VERTEBRAE; MODELS, BIOLOGICAL; OXYGEN; STRESS, MECHANICAL;

EID: 41549167595     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2008.02.002     Document Type: Article

References (74)

1. Bartels E.M., Fairbank J.C., Winlove C.P., and Urban J.P. Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain. Spine 23 (1998) 1-7
2. Bedford A., and Drumheller D.S. Theories of immiscible and structured mixtures. International Journal of Engineering Science 21 (1983) 863-960
3. Bernick S., and Cailliet R. Vertebral end-plate changes with aging of human vertebrae. Spine 7 (1982) 97-102
4. Best B.A., Guilak F., Setton L.A., Zhu W., Saed-Nejad F., Ratcliffe A., Weidenbaum M., and Mow V.C. Compressive mechanical properties of the human anulus fibrosus and their relationship to biochemical composition. Spine 19 (1994) 212-221
5. Bibby S.R., and Urban J.P. Effect of nutrient deprivation on the viability of intervertebral disc cells. European Spine Journal 13 (2004) 695-701
6. Bibby S.R., Fairbank J.C., Urban M.R., and Urban J.P. Cell viability in scoliotic discs in relation to disc deformity and nutrient levels. Spine 27 (2002) 2220-2228
7. Bibby S.R.S., Jones D.A., Ripley R.M., and Urban J.P. Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells. Spine 30 (2005) 487-496
8. Bonassar L.J., Grodzinsky A.J., Srinivasan A., Davila S.G., and Trippel S.B. Mechanical and physicochemical regulation of the action of insulin-like growth factor-I on articular cartilage. Archives of Biochemistry and Biophysics 379 (2000) 57-63
9. Brodin H. Path of nutrition in articular cartilage and intervertebral disk. Acta Orthopaedica Scandinavica 24 (1955) 177
10. Brown M.D., and Tsaltas T.T. Studies on the permeability of the intervertebral disc during skeletal maturation. Spine 1 (1976) 240-244
11. Chen J., Yan W., and Setton L.A. Static compression induces zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro. Matrix Biology 22 (2004) 573-583
12. Crock H.V., and Goldwasser M. Anatomic studies of the circulation in the region of the vertebral end-plate in adult Greyhound dogs. Spine 9 (1984) 702-706
13. Curnier A., He Q.-C., and Zysset P. Conewise linear elastic materials. Journal of Elasticity 37 (1995) 1-38
14. Ejeskar A., and Holm S. Oxygen tension measurements in the intervertebral disc. A methodological and experimental study. Upsala Journal of Medical Sciences 84 (1979) 83-93
15. Evans R.C., and Quinn T.M. Dynamic compression augments interstitial transport of a glucose-like solute in articular cartilage. Biophysical Journal 91 (2006) 1451-1457
16. Evans R.C., and Quinn T.M. Solute convection in dynamically compressed cartilage. Journal of Biomechanics 39 (2006) 1048-1055
17. Eyre D.R., Benya P., Buckwalter J., Caterson B., Heinegard D., Oegema T., Pearce R., Pope M., and Urban J. Intervertebral disk: basic science perspectives. In: Frymoyer J.W., and Gordon S.L. (Eds). New Perspectives on Low Back Pain (1989), American Academy of Orthopaedic Surgeons, Park Ridge, IL 147-207
18. Gu W.Y., and Yao H. Effects of hydration and fixed charge density on fluid transport in charged hydrated soft tissue. Annals of Biomedical Engineering 31 (2003) 1162-1170
19. Gu W.Y., Lai W.M., and Mow V.C. A mixture theory for charged-hydrated soft tissues containing multi- electrolytes: passive transport and swelling behaviors. Journal of Biomechanical Engineering 120 (1998) 169-180
20. Gu W.Y., Mao X.G., Foster R.J., Weidenbaum M., Mow V.C., and Rawlins B.A. The anisotropic hydraulic permeability of human lumbar anulus fibrosus. Influence of age, degeneration, direction, and water content. Spine 24 (1999) 2449-2455
21. Gu W.Y., Mao X.G., Rawlins B.A., Iatridis J.C., Foster R.J., Sun D.N., Weidenbaum M., and Mow V.C. Streaming potential of human lumbar anulus fibrosus is anisotropic and affected by disc degeneration. Journal of Biomechanics 32 (1999) 1177-1182
22. Gu W.Y., Yao H., Huang C.-Y., and Cheung H.S. New insight into deformation-dependent hydraulic permeability of gels and cartilage, and dynamic behavior of agarose gels in confined compression. Journal of Biomechanics 36 (2003) 593-598
23. Gu W.Y., Yao H., Vega A.L., and Flagler D. Diffusivity of ions in agarose gels and intervertebral disc: effect of porosity. Annals of Biomedical Engineering 32 (2004) 1710-1717
24. Hickey D.S., and Hukins D.W.L. Relation between the structure of the anulus fibrosus and the function and failure of the intervertebral disc. Spine 5 (1980) 106-116
25. Holm S., Maroudas A., Urban J.P., Selstam G., and Nachemson A. Nutrition of the intervertebral disc: solute transport and metabolism. Connective Tissue Research 8 (1981) 101-119
26. Horner H.A., and Urban J.P. 2001 Volvo award winner in basic science studies: effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc. Spine 26 (2001) 2543-2549
27. Houben G.B., Drost M.R., Huyghe J.M., Janssen J.D., and Husson A.H. Nonhomogeneous permeability of canine anulus fibrosus. Spine 1 (1997) 7-16
28. Huang C.-Y., and Gu W.Y. Effect of tension-compression nonlinearity on solute transport in charged hydrated fibrosus tissues under dynamic unconfined compression. Journal of Biomechanical Engineering 129 (2007) 423-429
29. Huang C.Y., Mow V.C., and Ateshian G.A. The role of flow-independent viscoelasticity in the biphasic tensile and compressive responses of articular cartilage. Journal of Biomechanical Engineering 123 (2001) 410-417
30. Huang C.-Y., Yuan T.-Y., Jackson A.R., Hazbun L., and Gu W.Y. Effects of low glucose concentrations on oxygen consumption rates of intervertebral disc cells. Spine 32 (2007) 2063-2069
31. Iatridis J.C., Setton L.A., Foster R.J., Rawlins B.A., Weidenbaum M., and Mow V.C. Degeneration affects the anisotropic and nonlinear behaviors of human anulus fibrosus in compression. Journal of Biomechanics 31 (1998) 535-544
32. Iatridis J.C., MacLean J.J., O'Brien M., and Stokes I.A. Measurements of proteoglycan and water content distribution in human lumbar intervertebral discs. Spine 32 (2007) 1493-1497
33. Ishihara H., and Urban J.P. Effects of low oxygen concentrations and metabolic inhibitors on proteoglycan and protein synthesis rates in the intervertebral disc. Journal of Orthopaedic Research 17 (1999) 829-835
34. Johnstone B., Urban J.P., Roberts S., and Menage J. The fluid content of the human intervertebral disc. Comparison between fluid content and swelling pressure profiles of discs removed at surgery and those taken postmortem. Spine 17 (1992) 412-416
35. Kitano T., Zerwekh J.E., Usui Y., Edwards M.L., Flicker P.L., and Mooney V. Biochemical changes associated with the symptomatic human intervertebral disk. Clinical Orthopaedics and Related Research 293 (1993) 372-377
36. Kraemer J., Kolditz D., and Gowin R. Water and electrolyte content of human intervertebral discs under variable load. Spine 10 (1985) 69-71
37. Lai W.M., Hou J.S., and Mow V.C. A triphasic theory for the swelling and deformation behaviors of articular cartilage. Journal of Biomechanical Engineering 113 (1991) 245-258
38. Lai W.M., Mow V.C., Sun D.D., and Ateshian G.A. On the electric potentials inside a charged soft hydrated biological tissue: streaming potential versus diffusion potential. Journal of Biomechanical Engineering 122 (2000) 336-346
39. Lundon K., and Bolton K. Structure and function of the lumbar intervertebral disk in health, aging, and pathologic conditions. Journal of Orthopaedic & Sports Physical Therapy 31 (2001) 291-303
40. MacLean J.J., Lee C.R., Alini M., and Iatridis J.C. The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc. Journal of Orthopaedic Research 23 (2005) 1120-1127
41. Marchand F., and Ahmed A.M. Investigation of the laminate structure of lumbar disc anulus fibrosus. Spine 15 (1990) 402-410
42. Maroudas A., Stockwell R.A., Nachemson A., and Urban J. Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. Journal of Anatomy 120 (1975) 113-130
43. Mauck R.L., Hung C.T., and Ateshian G.A. Modeling of neutral solute transport in a dynamically loaded porous permeable gel: implications for articular cartilage biosynthesis and tissue engineering. Journal of Biomechanical Engineering 125 (2003) 602-614
44. Moore R.J., Osti O.L., Vernon-Roberts B., and Fraser R.D. Changes in endplate vascularity after an outer anulus tear in the sheep. Spine 17 (1992) 874-878
45. Nachemson A. Intradiscal measurements of pH in patients with lumbar rhizopathies. Acta Orthopaedica Scandinavica 40 (1969) 23-42
46. Nachemson A., Lewin T., Maroudas A., and Freeman M.A. In vitro diffusion of dye through the end-plates and the annulus fibrosus of human lumbar inter-vertebral discs. Acta Orthopaedica Scandinavica 41 (1970) 589-607
47. Nimer E., Schneiderman R., and Maroudas A. Diffusion and partition of solutes in cartilage under static load. Biophysical Chemistry 106 (2003) 125-146
48. Ogata K., and Whiteside L.A. 1980 Volvo award winner in basic science. Nutritional pathways of the intervertebral disc. An experimental study using hydrogen washout technique. Spine 6 (1981) 211-216
49. O'Hara B.P., Urban J.P., and Maroudas A. Influence of cyclic loading on the nutrition of articular cartilage. Annals of the Rheumatic Diseases 49 (1990) 536-539
50. Ohshima H., Urban J.P., and Bergel D.H. Effect of static load on matrix synthesis rates in the intervertebral disc measured in vitro by a new perfusion technique. Journal of Orthopaedic Research 13 (1995) 22-29
51. Panagiotacopulos N.D., Pope M.H., Krag M.H., and Block R. Water content in human intervertebral discs. Part I. Measurement by magnetic resonance imaging. Spine 12 (1987) 912-917
52. Pearce R.H. Morphologic and chemical aspects of aging. In: Wood D.O., Goldberg V.M., and Woo S.L. (Eds). Musculoskeletal Soft-Tissue Aging: Impact on Mobility (1993), American Academy of Orthopaedic Surgeons, Rosemont, IL 363-379
53. Perie D., Korda D., and Iatridis J.C. Confined compression experiments on bovine nucleus pulposus and annulus fibrosus: sensitivity of the experiment in the determination of compressive modulus and hydraulic permeability. Journal of Biomechanics 38 (2005) 2164-2171
54. Quinn T.M., Kocian P., and Meister J.J. Static compression is associated with decreased diffusivity of dextrans in cartilage explants. Archives of Biochemistry and Biophysics 384 (2000) 327-334
55. Quinn T.M., Morel V., and Meister J.J. Static compression of articular cartilage can reduce solute diffusivity and partitioning: implications for the chondrocyte biological response. Journal of Biomechanics 34 (2001) 1463-1469
56. Roberts S., Urban J.P., Evans H., and Eisenstein S.M. Transport properties of the human cartilage endplate in relation to its composition and calcification. Spine 21 (1996) 415-420
57. Selard E., Shirazi-Adl A., and Urban J. Finite element study of nutrient diffusion in the human intervertebral disc. Spine 28 (2003) 1945-1953
58. Soltz M.A., and Ateshian G.A. A conewise linear elasticity mixture model for the analysis of tension- compression nonlinearity in articular cartilage. Journal of Biomechanical Engineering 122 (2000) 576-586
59. Soukane D.M., Shirazi-Adl A., and Urban J. Analysis of nonlinear coupled diffusion of oxygen and lactic acid in intervertebral discs. Journal of Biomechanical Engineering 127 (2005) 1121-1126
60. Soukane D.M., Shirazi-Adl A., and Urban J.P. Computation of coupled diffusion of oxygen, glucose and lactic acid in an intervertebral disc. Journal of Biomechanics (2007) 10.1016/j.jbiomech.2007.01.003
61. Sun D.N., Gu W.Y., Guo X.E., Lai W.M., and Mow V.C. A mixed finite element formulation of triphasic mechano-electrochemical theory for charged, hydrated biological soft tissues. International Journal for Numerical Methods in Engineering 45 (1999) 1375-1402
62. Urban J.P.G., and Maroudas A. The chemistry of the intervertebral disc in relation to its physiological function and requirements. Clinics in Rheumatic Diseases 6 (1980) 51-77
63. Urban J.P., and Maroudas A. Swelling of the intervertebral disc in vitro. Connect Tissue Research 9 (1981) 1-10
64. Urban J.P., and McMullin J.F. Swelling pressure of the lumbar intervertebral discs: influence of age, spinal level, composition, and degeneration. Spine 13 (1988) 179-187
65. Urban J.P.G., Holms S., Maroudas A., and Nachemson A. Nutrition of the intervertebral disc: an in vivo study of solute transport. Clinical Pediatrics 129 (1977) 101-114
66. Urban J.P., Holm S., and Maroudas A. Diffusion of small solutes into the intervertebral disc: as in vivo study. Biorheology 15 (1978) 203-221
67. Urban J.P., Maroudas A., Bayliss M.T., and Dillon J. Swelling pressures of proteoglycans at the concentrations found in cartilaginous tissues. Biorheology 16 (1979) 447-464
68. Urban J.P., Holm S., Maroudas A., and Nachemson A. Nutrition of the intervertebral disc: effect of fluid flow on solute transport. Clinical Orthopaedics 170 (1982) 296-302
69. Walsh A.J., and Lotz J.C. Biological response of the intervertebral disc to dynamic loading. Journal of Biomechanics 37 (2004) 329-337
70. Yao H., and Gu W.Y. Physical signals and solute transport in cartilage under dynamic unconfined compression: finite element analysis. Annals of Biomedical Engineering 32 (2004) 380-390
71. Yao H., and Gu W.Y. Physical signals and solute transport in human intervertebral disc during compressive stress relaxation: 3D finite element analysis. Biorheology 43 (2006) 323-335
72. Yao H., and Gu W.Y. Convection and diffusion in charged hydrated soft tissues: a mixture theory approach. Biomechanics and Modeling in Mechanobiology 6 (2007) 63-72
73. Yao H., and Gu W.Y. Three-dimensional inhomogeneous triphasic finite-element analysis of physical signals and solute transport in human intervertebral disc under axial compression. Journal of Biomechanics 40 (2007) 2071-2079
74. Yao H., Justiz M.A., Flagler D., and Gu W.Y. Effects of swelling pressure and hydraulic permeability on dynamic compressive behavior of lumbar annulus fibrosus. Annals of Biomedical Engineering 30 (2002) 1234-1241