Neurosteroids and epileptogenesis in the pilocarpine model: Evidence for a relationship between P450scc induction and length of the latent period

Epilepsia

Volumn 50, Issue SUPPL. 1, 2009, Pages 53-58

  Biagini, Giuseppe ^a   Longo, Daniela ^a   Baldelli, Enrica ^a   Zoli, Michele ^a   Rogawski, Michael A ^b   Bertazzoni, Giuliano ^c   Avoli, Massimo ^c,d  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

Epileptogenesis; Finasteride; Glia; Neurosteroid; Pilocarpine; Temporal lobe epilepsy

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); DIAZEPAM; FINASTERIDE; HEME OXYGENASE 1; NEUROSTEROID; PILOCARPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DRUG INHIBITION; EPILEPTIC STATE; EPILEPTOGENESIS; GLIA CELL; HIPPOCAMPUS; MALE; MICROGLIA; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEIZURE;

ANIMALS; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DISEASE MODELS, ANIMAL; ENZYME INDUCTION; MALE; NEUROTRANSMITTER AGENTS; PILOCARPINE; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, GABA-A; RECURRENCE; SEIZURES; STATUS EPILEPTICUS;

EID: 58149280525     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01971.x     Document Type: Article

References (13)

1. Avoli M, D'Antuono M, Louvel J, Köhling R, Biagini G, Pumain R, D'Arcangelo G, Tancredi V 2002) Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system. Prog Neurobiol 68 : 167 207.
2. Belluardo N, Mudo G, Jiang XH, Condorelli DF 1996) Induction of astroglial gene expression by experimental seizures in the rat: spatio-temporal patterns of the early stages. Glia 16 : 174 186.
3. Biagini G, Frasoldati A, Fuxe K, Agnati LF 1994) The concept of astrocyte-kinetic drug in the treatment of neurodegenerative diseases: evidence for L-deprenyl-induced activation of reactive astrocytes. Neurochem Int 25 : 17 22.
4. Biagini G, Baldelli E, Longo D, Pradelli L, Zini I, Rogawski MA, Avoli M 2006) Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy. Exp Neurol 201 : 519 524.
5. Jung-Testas I, Hu ZY, Baulieu EE, Robel P 1989) Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells. Endocrinology 125 : 2083 2091.
6. A receptors. Prog Neurobiol 71 : 67 80.
7. Liu Z, Nagao T, Desjardins GC, Gloor P, Avoli M 1994) Quantitative evaluation of neuronal loss in the dorsal hippocampus in rats with long-term pilocarpine seizures. Epilepsy Res 17 : 237 247.
8. Mathern GW, Adelson PD, Cahan LD, Leite JP 2002) Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited. Prog Brain Res 135 : 237 251.
9. Mellon SH, Griffin LD 2002) Neurosteroids: biochemistry and clinical significance. Trends Endocrinol Metab 13 : 35 43.
10. Racine RJ 1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32 : 281 394.
11. Rogawski MA, Reddy DS 2004) Neurosteroids: endogenous modulators of seizure susceptibility. In Rho JM, Sankar R, Cavazos J (Eds) Epilepsy: scientific foundations of clinical treatment, Marcel Dekker, New York, pp. 319 355.
12. Steward O, Torre ER, Tomasulo R, Lothman E 1991) Neuronal activity up-regulates astroglial gene expression. Proc Natl Acad Sci U S A 88 : 6819 6823.
13. Zwain IH, Yen SS 1999) Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain. Endocrinology 140 : 3843 3852.