Pectin-based microspheres for colon-specific delivery of vancomycin

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 1, 2009, Pages 41-46

  Bigucci, Federica ^a   Luppi, Barbara ^a   Monaco, Libera ^a   Cerchiara, Teresa ^b   Zecchi, Vittorio ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Chitosan; Colon specific delivery; Hydrogel; Mucoadhesion; Pectin

Indexed keywords

CHITOSAN; MICROSPHERE; PECTIN; POLYGALACTURONASE; VANCOMYCIN;

ARTICLE; COLON; DRUG DELIVERY SYSTEM; DRUG SPECIFICITY; HYDROGEL; SPRAY DRYING;

EID: 58149271083     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.01.0006     Document Type: Article

References (24)

1. Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems. Eur J Pharm Sci 2003; 6: 32-66.
2. Jain A et al. Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon. J Pharm Pharm Sci 2007; 10: 86-128.
3. Sinha VR, Kumria R. Polysaccharides in colon-specific drug delivery. Int J Pharm 2001: 224: 19-38.
4. Sinha VR, Kumria R. Microbially triggered drug delivery to the colon. Eur J Pharm Sci 2003: 18: 3-18.
5. Liu LS et al. Pectin-based systems for colon-specific drug delivery via oral route. Biomaterials 2003; 24: 3333-3343.
6. Berger J et al. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm 2004; 57: 35-52.
7. George M, Abraham TE. Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan - a review. J Control Release 2006; 114: 1-14.
8. Koga D. Chitin enzymology-chitinase. In: Chen R, Chen HC, eds. Advances in Chitin Science, vol. 3. Taiwan: The National Taiwan Ocean University, 1998: 16-23.
9. Muzzarelli RAA. Human enzymatic activities related to the therapeutic administration of chitin derivatives. Cell Mol Life Sci 1997; 53: 131-140.
10. He P et al. In vitro evaluation of the mucoadhesive properties of chitosan microspheres. Int J Pharm 1998; 166: 75-88.
11. Nakamura F et al. In vitro and in vivo nasal mucoadhesion of some water-soluble polymers. Int J Pharm 1996: 134: 173-181.
12. Cerchiara T et al. Controlled release of vancomycin from freeze-dried chitosan salts coated with different fatty acids by spray-drying. J Microencapsul 2003; 20: 473-478.
13. Cerchiara T et al. Chitosan salts as nasal sustained delivery systems for peptidic drugs. J Pharm Pharmacol 2003: 55: 1623-1627.
14. Marudova M et al. Pectin-chitosan interactions and gel formation. Carbohydr Res 2004; 339: 1933-1939.
15. Thirawong N et al. Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer. Eur J Pharm Biopharm 2007; 67: 132-140.
16. Ashford M et al. An evaluation of pectin as a carrier for drug targeting to the colon. J Control Release 1993; 26: 213-220.
17. Munjeri O et al. Hydrogel beads based on amidated pectins for colon-specific drug delivery: the role of chitosan in modifying drug release. J Control Release 1997; 46: 273-278.
18. Fernández-Hervás MJ. Fell JT. Pectin/chitosan mixtures as coatings for colon-specific drug delivery: an in vitro evaluation. Int J Pharm 1998: 169: 115-119.
19. Yao KD et al. Swelling behaviour of pectin/chitosan complex films. J Appl Polym Sci 1996: 60: 279-283.
20. Duchene D et al. Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug Dev Ind Pharm 1998: 14: 283-318
21. Gurny R et al. Bioadhesive intraoral release systems: design, testing and analysis. Biomaterials 1984; 5: 336-340.
22. Peppas NA. Buri PA. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. J Control Release 1985: 2: 257-275.
23. Madsen F et al. A Theological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration. J Control Release 1998: 50: 167-178.
24. Peppas NA, Sahlin JJ. Hydrogels as mucoadhesive and bioadhesive materials: a review. Biomaterials 1996: 17: 1553-1561.