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Volumn 15, Issue 1, 2009, Pages 25-28

Exercise-induced asthma

Author keywords

Asthma; Diagnosis; Exercise; Treatment

Indexed keywords

ASCORBIC ACID; BRONCHODILATING AGENT; ENDOTHELIN 1; EOSINOPHIL CATIONIC PROTEIN; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LIPOXIN A; METHACHOLINE; MONTELUKAST; NITRIC OXIDE; PHOSPHOLIPASE A2; PLACEBO; SALBUTAMOL; SHORT ACTING DRUG;

EID: 58149271075     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0b013e32831da8ab     Document Type: Review
Times cited : (27)

References (36)
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    • Important study that discusses the issues surrounding screening for EIB. The economic, logistical, and practical implications of screening are discussed in addition to the importance of the development of standardized testing procedures to document EIB
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    • A small study demonstrating decrease of lipoxin A4 in children with EIB
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    • Exercise challenge test in 3- to 6-year-old asthmatic children
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    • Study of 47 asthmatics that showed montelukast was effective in attenuating EIB
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    • Comparative effects of a high- intensity interval warm-up and salbutamol on the bronchoconstrictor response to exercise in asthmatic athletes
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    • Mickleborough TD, Lindley MR, Turner LA. Comparative effects of a high- intensity interval warm-up and salbutamol on the bronchoconstrictor response to exercise in asthmatic athletes. Int J Sports Med 2007; 28:456-462. Authors showed that combining warm-up with albuterol was more effective than either treatment approach alone. This underscores the importance of using adjunctive approaches to managing EIB.
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    • Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma
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    • TBXA2R gene polymorphism and respon- siveness to leukotriene receptor antagonist in children with asthma
    • Authors showed a particular genotype may be a predictive marker of a clinical response to montelukast in Korean asthmatic children with EIB. This is an important study demonstrating the potential value of pharmacogenomics as a future treatment approach to EIB
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    • Responsiveness to montelukast is associated with bronchial hyperresponsiveness and total immunoglobulin E but not polymorphisms in the leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes in Korean children with exercise-induced asthma (EIA)
    • Lee SY, Kim HB, Kim JH, et al. Responsiveness to montelukast is associated with bronchial hyperresponsiveness and total immunoglobulin E but not polymorphisms in the leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes in Korean children with exercise-induced asthma (EIA). Clin Exp Allergy 2007; 37:1487-1493.
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