A phase II study of sequential docetaxel and gemcitabine followed by docetaxel and carboplatin as first-line therapy for non-small cell lung cancer

Medical Oncology

Volumn 25, Issue 3, 2008, Pages 303-308

  Karapanagiotou, Eleni M ^a   Charpidou, Adrianni ^a   Tzannou, Ifigenia ^a   Dilana, Kalliopi ^a   Kotteas, Elias ^a   Tourkantonis, Ioannis ^a   Kosmas, Epaminondas ^a   Provata, Aspasia ^a   Syrigos, Kostas ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Carboplatin; Combination chemotherapy; Docetaxel; Doublet regimens; First line therapy; Gemcitabine; NSCLC therapy

Indexed keywords

CARBOPLATIN; DEXAMETHASONE; DOCETAXEL; GEMCITABINE; GRANULOCYTE COLONY STIMULATING FACTOR; ONDANSETRON; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE; DRUG DERIVATIVE; TAXOID;

ADULT; AGED; ALOPECIA; ANEMIA; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER MORTALITY; CANCER PATIENT; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; DIARRHEA; DISEASE FREE SURVIVAL; DRUG DOSE SEQUENCE; DRUG HYPERSENSITIVITY; DRUG TOLERABILITY; FEMALE; HUMAN; LUNG NON SMALL CELL CANCER; MALE; METASTASIS; MULTIPLE CYCLE TREATMENT; NAUSEA AND VOMITING; NEUROTOXICITY; NEUTROPENIA; PERIPHERAL NEUROPATHY; PHASE 2 CLINICAL TRIAL; PREMEDICATION; PRIORITY JOURNAL; RECURRENT CANCER; RISK FACTOR; SKIN DISEASE; SURVIVAL RATE; SURVIVAL TIME; THROMBOCYTOPENIA; TREATMENT OUTCOME; KAPLAN MEIER METHOD; LUNG TUMOR; MIDDLE AGED; MORTALITY;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CARCINOMA, NON-SMALL-CELL LUNG; DEOXYCYTIDINE; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; LUNG NEOPLASMS; MALE; MIDDLE AGED; TAXOIDS;

EID: 58149265802     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12032-007-9036-9     Document Type: Article

References (30)

1. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. Non-small Cell Lung Cancer Collaborative Group. BMJ 1995;311(7010):899-909.
2. DH Johnson 2000 Locally advanced, unresectable non-small cell lung cancer: new treatment strategies Chest 117 4 Suppl 1 123S 6S
3. MA Socinski DE Morris GA Masters R Lilenbaum 2003 Chemotherapeutic management of stage IV non-small cell lung cancer Chest 123 1 Suppl 226S 43S
4. JH Schiller D Harrington CP Belani 2002 Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer N Engl J Med 346 2 92 8
5. DJ Stewart GP Raaphorst J Yau AR Beaubien 1996 Active vs. passive resistance, dose-response relationships, high dose chemotherapy, and resistance modulation: a hypothesis Invest New Drugs 14 2 115 30
6. IE Smith ME O'Brien DC Talbot 2001 Duration of chemotherapy in advanced non-small-cell lung cancer: a randomized trial of three versus six courses of mitomycin, vinblastine, and cisplatin J Clin Oncol 19 5 1336 43
7. MA Socinski MJ Schell A Peterman 2002 Phase III trial comparing a defined duration of therapy versus continuous therapy followed by second-line therapy in advanced-stage IIIB/IV non-small-cell lung cancer J Clin Oncol 20 5 1335 43
8. RS Day 1986 Treatment sequencing, asymmetry, and uncertainty: protocol strategies for combination chemotherapy Cancer Res 46 8 3876 85
9. L Norton R Simon 1977 Tumor size, sensitivity to therapy, and design of treatment schedules Cancer Treat Rep 61 7 1307 17
10. FV Fossella JS Lee DM Shin 1995 Phase II study of docetaxel for advanced or metastatic platinum-refractory non-small-cell lung cancer J Clin Oncol 13 3 645 51
11. V Georgoulias A Ardavanis A Agelidou 2004 Docetaxel versus docetaxel plus cisplatin as front-line treatment of patients with advanced non-small-cell lung cancer: a randomized, multicenter phase III trial J Clin Oncol 22 13 2602 09
12. KN Syrigos I Dannos G Dionellis 2005 Bi-weekly administration of docetaxel and gemcitabine as first-line therapy for non-small cell lung cancer: a phase II study Anticancer Res 25 5 3489 93
13. V Georgoulias A Ardavanis X Tsiafaki 2005 Vinorelbine plus cisplatin versus docetaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III randomized trial J Clin Oncol 23 13 2937 45
14. Scagliotti GV, Selvaggi G. Non-platinum-based chemotherapy for advanced non-small cell lung cancer. In: Syrigos KN, Nutting C, Roussos C, editors. Tumors of the chest. Biology, diagnosis and management. New York: Springer; 2006. p. 289-303.
15. P Comella N Panza L Manzione 2000 Interim analysis of a phase III trial comparing cisplatin, gemcitabine, and vinorelbine vs. either cisplatin and gemcitabine or cisplatin and vinorelbine in advanced non small-cell lung cancer. A Southern Italy Cooperative Oncology Group Study Clin Lung Cancer 1 3 202 7
16. P Comella 2000 Interim analysis of a phase III trial. Triple- vs. double-agent chemotherapy for advanced non-small-cell lung cancer. Southern Italy Cooperative Oncology Group Oncology (Williston Park) 14 7 Suppl 4 35 40
17. P Comella G Frasci P Carnicelli 2004 Gemcitabine with either paclitaxel or vinorelbine vs. paclitaxel or gemcitabine alone for elderly or unfit advanced non-small-cell lung cancer patients Br J Cancer 91 3 489 97
18. L Crino GV Scagliotti S Ricci 1999 Gemcitabine and cisplatin versus mitomycin, ifosfamide, and cisplatin in advanced non-small-cell lung cancer: a randomized phase III study of the Italian Lung Cancer Project J Clin Oncol 17 11 3522 30
19. Preliminary results of a randomized study comparing paclitaxel and carboplatin (PC) with or without gemcitabine (G) in newly diagnosed non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol;2000.
20. Cisplatin/Gemzar vs Cisplatin/Gemcitabine/Vinorelbine versus sequential doublets of Vinorelbine/Gemcitabine followed by Ifosfamide/Vinorelbine in Advanced non-small cell lung cancer: results of a Spanish Lung Cancer Group phase III trial. Proc ASCO; 2 A.D.;2001.
21. DM Cobo CE Villar DI Ales 2006 Gemcitabine and vinorelbine followed by weekly docetaxel in patients with advanced non-small-cell lung cancer: a phase II trial of sequential chemotherapy Clin Transl Oncol 8 10 742 9
22. J Cortes J Rodriguez E Calvo 2004 Paclitaxel, cisplatin, and vinorelbine combination chemotherapy in metastatic non-small-cell lung cancer Am J Clin Oncol 27 3 299 303
23. AM Mauer RH Ansari PC Hoffman 2003 Phase I/II investigation of paclitaxel, ifosfamide and carboplatin for advanced non-small-cell lung cancer Ann Oncol 14 5 722 8
24. R Pirker 2002 Two- versus three-drug combinations in the chemotherapy of advanced non-small-cell lung cancer Lung Cancer 38 Suppl 3 S53 5
25. JL Pujol JL Breton R Gervais 2005 Gemcitabine-docetaxel versus cisplatin-vinorelbine in advanced or metastatic non-small-cell lung cancer: a phase III study addressing the case for cisplatin Ann Oncol 16 4 602 10
26. PJ Souquet EH Tan PJ Rodrigues 2002 GLOB-1: a prospective randomised clinical phase III trial comparing vinorelbine-cisplatin with vinorelbine-ifosfamide-cisplatin in metastatic non-small-cell lung cancer patients Ann Oncol 13 12 1853 61
27. A Chiappori G Simon C Williams 2005 Phase II study of first-line sequential chemotherapy with gemcitabine-carboplatin followed by docetaxel in patients with advanced non-small cell lung cancer Oncology 68 4-6 382 90
28. T Giannakakis S Kakolyris E Theodoropoulos 2002 A multicenter phase II study of docetaxel and carboplatin combination as front-line treatment in advanced non-small cell lung cancer Anticancer Res 22 6B 3743 8
29. M Jahanzeb G Sarna R Hirsch 2004 Docetaxel and carboplatin as first-line therapy in advanced non-small cell lung carcinoma: a phase II study Anticancer Res 24 2C 1239 42
30. S Thongprasert S Soorraritchingchai B Chewaskulyong C Charoentum S Munprakan 2006 A phase II study of docetaxel and carboplatin in Thai patients with advanced non-small-cell lung cancer J Med Assoc Thai 89 2 152 9