Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures

Epilepsia

Volumn 50, Issue 1, 2009, Pages 83-87

  Zheng, Thomas ^a   Clarke, Alison L ^b   Morris, Margaret J ^c   Reid, Christopher A ^b   Petrou, Steven ^b   O'Brien, Terence J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Absence seizures; Carbamazepine; GAERS; Oxcarbazepine; Seizure aggravation

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CARBAMAZEPINE; DRUG METABOLITE; MONOHYDROXY DERIVATIVE; OXCARBAZEPINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG STRUCTURE; FEMALE; GENETIC ABSENCE EPILEPTIC RATS FROM STRASBOURG; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; RAT STRAIN; RECEPTOR POTENTIAL; SEIZURE; XENOPUS;

ANIMALS; ANTICONVULSANTS; BRAIN; CARBAMAZEPINE; ELECTROENCEPHALOGRAPHY; EPILEPSY, ABSENCE; FEMALE; RATS; RECEPTORS, GABA-A;

EID: 58149260298     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01759.x     Document Type: Article

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