Biotechnology: Common excipients impair detection of protein aggregates during sedimentation velocity analytical ultracentrifugation

Journal of Pharmaceutical Sciences

Volumn 98, Issue 1, 2009, Pages 50-62

  Cabrielson, John P ^a,b   Arthur, Kelly K ^a   Kendrick, Brent S ^a   Randolph, Theodore W ^b   Stoner, Michael R ^a  

^a AMGEN INC   (United States)

^b UCB 450   (United States)

Author keywords

Analytical ultracentrifugation; Formulation; Protein aggregation; SEDFIT; Sedimentation velocity

Indexed keywords

EXCIPIENT; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; SORBITOL; PROTEIN;

ARTICLE; COMPUTER SIMULATION; GEL PERMEATION CHROMATOGRAPHY; PROTEIN AGGREGATION; PROTEIN DETERMINATION; QUANTITATIVE ANALYSIS; SEDIMENTATION RATE; SOLVENT EFFECT; ULTRACENTRIFUGATION; CHEMISTRY; COMPARATIVE STUDY; METHODOLOGY; PHYSIOLOGY; PROTEIN BINDING;

CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; PROTEIN BINDING; PROTEINS; ULTRACENTRIFUGATION;

EID: 58149250236     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21403     Document Type: Article

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