Nodular heterotopia: A neuropathological study of 24 patients undergoing surgery for drug-resistant epilepsy

Epilepsia

Volumn 50, Issue 1, 2009, Pages 116-124

  Meroni, Alessandra ^a   Galli, Carlo ^b   Bramerio, Manuela ^b   Tassi, Laura ^b   Colombo, Nadia ^b   Cossu, Massimo ^b   Lo Russo, Giorgio ^b   Garbelli, Rita ^a   Spreafico, Roberto ^a  

^a DEPARTMENT OF NEUROSURGERY   (Italy)

^b OSPEDALE NIGUARDA CA GRANDA   (Italy)

Author keywords

Dual pathology; Neuropathology of epilepsy; Nodular heterotopia

Indexed keywords

ANTICONVULSIVE AGENT;

ADOLESCENT; ADULT; ARTICLE; BRAIN NERVE CELL; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORTICAL DYSPLASIA; DATA ANALYSIS; DRUG DOSE REDUCTION; DRUG RESISTANT EPILEPSY; DRUG WITHDRAWAL; EPILEPSY; FEMALE; GLIA CELL; GLIOMA; HETEROTOPIA; HIPPOCAMPAL SCLEROSIS; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; INTRACTABLE EPILEPSY; MALE; NEUROPATHOLOGY; NODULAR HETEROTOPIA; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; TEMPORAL LOBE;

ADOLESCENT; BRAIN DISEASES; CHILD; CHILD, PRESCHOOL; CHORISTOMA; DRUG RESISTANCE; ELECTROENCEPHALOGRAPHY; EPILEPSY, TEMPORAL LOBE; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; MAGNETIC RESONANCE IMAGING; MALE; NERVE FIBERS, MYELINATED; NERVE NET; TEMPORAL LOBE;

EID: 58149248037     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01717.x     Document Type: Article

References (33)

1. Aghakhani Y, Kinay D, Gotman J, Soualmi L, Andermann F, Olivier A, Dubeau F 2005) The role of periventricular nodular heterotopia in epileptogenesis. Brain 128 : 641 651.
2. Barkovich AJ, Kjos BO 1992) Gray matter heterotopias: MR characteristics and correlation with developmental and neurologic manifestations. Radiology 182 : 493 4999.
3. Barkovich AJ, Kuzniecky RI 2000) Gray matter heterotopia. Neurology 55 : 1603 1608.
4. Barkovich AJ, Kuzniecky RI, Jackson GD, Guerrini R, Dobyns WB 2001) Classification system for malformations of cortical development: update. Neurology 57 : 2168 2178.
5. Barkovich AJ, Kuzniecky RI, Jackson GD, Guerrini R, Dobyns WB 2005) A developmental and genetic classification for malformations of cortical development. Neurology 65 : 1873 1887.
6. Battaglia G, Arcelli P, Granata T, Selvaggio M, Andermann F, Dubeau F, Olivier A, Tampieri D, Villemure JG, Avoli M, Avanzini G, Spreafico R 1996) Neuronal migration disorders and epilepsy: a morphological analysis of three surgically treated patients. Epilepsy Res 26 : 49 58.
7. Battaglia G, Chiapparini L, Franceschetti S, Freri E, Tassi L, Bassanini S, Villani F, Spreafico R, D'Incerti L, Granata T 2006) Periventricular nodular heterotopia: classification, epileptic history, and genesis of epileptic discharges. Epilepsia 47 : 86 97.
8. Cossu M, Cardinale F, Castana L, Citterio A, Francione S, Tassi L, Benabid AL, Lo Russo G 2005) Stereoelectroencephalography in the presurgical evaluation of focal epilepsy: a retrospective analysis of 215 procedures. Neurosurgery 57 : 706 718.
9. Dobyns WB, Anderman E, Anderman F, Czapansky-Beilman D, Dubeau F, Dulac O, Guerrini R, Hirsch B, Ledbetter DH, Lee NS, Motte J, Pinard JM, Radtke RA, Ross ME, Tampieri D, Walsh CA, Truwit CL 1996) X-linked malformations of neuronal migration. Neurology 47 : 331 339.
10. Dubeau F, Tampieri D, Lee N, Andermann E, Carpenter S, Leblanc R, Olivier A, Radtke R, Illemure JG, Andermann F 1995) Periventricular and subcortical nodular heterotopia. A study of 33 patients. Brain 118 : 1273 1287.
11. Eksioglu YZ, Scheffer IE, Cardenas P, Knoll J, DiMario F, Ramsby G, Berg M, Kamuro K, Berkovic SF, Duyk GM, Parisi J, Huttenlocher PR, Walsh CA 1996) Periventricular heterotopia: an X-linked dominant epilepsy locus causing aberrant cerebral cortical development. Neuron 16 : 77 87.
12. Engel J 1987) Outcome with respect to epileptic seizures. In Engel J (Ed) Surgical treatment of the epilepsies. Raven Press, New York, pp. 553 571.
13. Fauser S, Schulze-Bonhage A, Honegger J, Carmona H, Huppertz HJ, Pantazis G, Rona S, Bast T, Strobl K, Steinhoff BJ, Korinthenberg R, Rating D, Volk B, Zentner J 2004) Focal cortical dysplasias: surgical outcome in 67 patients in relation to histological subtypes and dual pathology. Brain 127 : 2406 2418.
14. Garbelli R, Meroni A, Magnaghi G, Beolchi MS, Ferrario A, Tassi L, Bramerio M, Spreafico R 2006) Architectural (Type IA) focal cortical dysplasia and parvalbumin immunostaining in temporal lobe epilepsy. Epilepsia 47 : 949 951.
15. Gòmez-Ansòn B, Thom M, Moran N, Stevens J, Scaravilli F 2000) Imaging and radiological-pathological correlation in histologically proven cases of focal cortical dysplasia and other glial and neuroglial malformative lesions in adults. Neuroradiology 42 : 157 167.
16. Hannan AJ, Servotte S, Katsnelson A, Sisodiya S, Blakemore C, Squier M, Molnár Z 1999) Characterization of nodular neuronal heterotopia in children. Brain 122 : 219 238.
17. Hildebrandt M, Pieper T, Winkler P, Kolodziejczyk D, Holthausen H, Blumcke I 2005) Neuropathological spectrum of cortical dysplasia in children with severe focal epilepsies. Acta Neuropathol (Berl) 110 : 1 11.
18. Kakita A, Hayashi S, Moro F, Guerrini R, Ozawa T, Ono K, Kameyama S, Walsh CA, Takahashi H 2002) Bilateral periventricular nodular heterotopia due to filamin 1 gene mutation: widespread glomeruloid microvascular anomaly and dysplastic cytoarchitecture in the cerebral cortex. Acta Neuropathol (Berl) 104 : 649 657.
19. Kobayashi E, Bagshaw AP, Grova C, Gotman J, Dubeau F 2006) Grey matter heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders. Brain 129 : 366 374.
20. Lévesque MF, Nakasato N, Vinters HV, Babb TL 1991) Surgical treatment of limbic epilepsy associated with extrahippocampal lesions: the problem of dual pathology. J Neurosurg 75 : 364 370.
21. Li LM, Dubeau F, Andermann F, Fish DR, Watson C, Cascino GD, Berkovic SF, Moran JN, Duncan JS, Olivier A, Leblanc R, Harkness W 1997) Periventricular nodular heterotopia and intractable temporal lobe epilepsy: poor outcome after temporal lobe resection. Ann Neurol 41 : 662 668.
22. Montenegro MA, Guerriero MM, Lopes-Cendes I, Guerriero CAM, Cendes F 2002) Interrelationship of genetics and prenatal injury in the genesis of malformations of cortical development. Arch Neurol 59 : 1147 1153.
23. Palmini A, Luders HO 2002) Classification issues in malformations caused by abnormalities of cortical development. Neurosurg Clin N Am 13 : 1 16.
24. Palmini A, Najm I, Avanzini G, Babb T, Guerrini R, Foldvary-Schaefer N, Jackson G, Lüders HO, Prayson R, Spreafico R, Vinters HV 2004) Terminology and classification of the cortical dysplasias. Neurology 62 : 2 8.
25. Parrini E, Ramazzotti A, Dobyns WB, Mei D, Moro F, Veggiotti P, Marini C, Brilstra EH, Dalla Bernardina B, Goodwin L, Bodell A, Jones MC, Nangeroni M, Palmeri S, Said E, Sander JW, Striano P, Takahashi Y, Van Maldergem L, Leonardi G, Wright M, Walsh CA, Gerrini R 2006) Periventricular heterotopia: phenotypic heterogeneity and correlation with filamin A mutations. Brain 129 : 1892 1906.
26. Raymond AA, Fish DR, Stevens JM, Sisodiya SM, Alsanjari N, Shorvon SD 1994) Subependymal heterotopia: a distinct neuronal migration disorder associated with epilepsy. J Neurol Neurosurg Psychiatry 57 : 1195 1202.
27. Raymond AA, Fish DR, Sisodiya SM, Alsanjari N, Stevens JM, Shorvon SD 1995) Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEG and neuroimaging features in 100 adult patients. Brain 118 : 629 660.
28. Santi MR, Golden JA 2001) Periventricular heterotopia may result from radial glial fiber disruption. J Neuropathol Exp Neurol 60 : 856 862.
29. Spreafico R, Battaglia G, Arcelli P, Andermann F, Dubeau F, Palmini A, Olivier A, Villemure JG, Tampieri D, Avanzini G, Avoli M 1998) Cortical dysplasia. An immunocytochemical study of three patients. Neurology 50 : 27 36.
30. Tassi L, Colombo N, Cossu M, Mai R, Francione S, Lo Russo G, Galli C, Bramerio M, Battaglia G, Garbelli R, Meroni A, Spreafico R 2005) Electroclinical, MRI and neuropathological study of 10 patients with nodular heterotopia, with surgical outcomes. Brain 128 : 321 337.
31. Thom M, Sisodiya S, Harkness W, Scaravilli F 2001) Microdysgenesis in temporal lobe epilepsy. A quantitative and immunohistochemical study of white matter neurones. Brain 124 : 2299 2309.
32. Thom M, Martinian L, Parnavelas JG, Sisodiya SM 2004) Distribution of cortical interneurons in grey matter heterotopia in patients with epilepsy. Epilepsia 45 : 916 923.
33. Wieck G, Leventer RJ, Squier WM, Jansen A, Andermann E, Dubeau F, Ramazzotti A, Guerrini R, Dobyns WB 2005) Periventricular nodular heterotopia with overlying polymicrogyria. Brain 128 : 2811 2821.