Skeletal muscle protein synthesis after active or passive ascent to high altitude

Medicine and Science in Sports and Exercise

Volumn 38, Issue 6, 2006, Pages 1082-1087

  Imoberdorf, Reinhard ^a,b   Garlick, Peter J ^c   McNurlan, Margaret A ^d   Casella, George A ^d   Marini, Juan C ^c   Turgay, Meral ^a   Bärtsch, Peter ^e   Ballmer, Peter E ^a,b  

^a UNIVERSITY OF BERN   (Switzerland)

^b CANTONAL HOSPITAL WINTERTHUR   (Switzerland)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d STONY BROOK UNIVERSITY   (United States)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cortisol; Hyperventilation; Hypobaric hypoxia; Respiratory alkalosis

Indexed keywords

GLUCOCORTICOID; HYDROCORTISONE; ISOTOPE; LIOTHYRONINE; MUSCLE PROTEIN; PHENYLALANINE; SOMATOMEDIN C; THYROTROPIN; THYROXINE;

ADULT; ALKALOSIS; ALTITUDE; ARTICLE; CLIMBING; EXERCISE; EXPOSURE; FEMALE; HELICOPTER; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYDROCORTISONE URINE LEVEL; HYPOXIA; LIOTHYRONINE BLOOD LEVEL; MALE; NORMAL HUMAN; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SKELETAL MUSCLE; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

ADULT; ALKALOSIS; ALTITUDE; ANOXIA; DEUTERIUM; ENVIRONMENTAL EXPOSURE; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROCORTISONE; INSULIN-LIKE GROWTH FACTOR I; MALE; METHYLHISTIDINES; MIDDLE AGED; MOUNTAINEERING; MUSCLE PROTEINS; MUSCLE, SKELETAL; NITROGEN; PHENYLALANINE; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 33745160358     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.mss.0000222836.66391.35     Document Type: Article

References (42)

1. BALLMER, P. E., M. A. MCNURLAN, E. MILNE, et al. Measurement of albumin synthesis in man: A new approach, employing stable isotopes. Am. J. Physiol. 259:E797-E803, 1990.
2. CARRARO, F., Ch. A. STUART, W. H. HARTL, J. ROSENBLATT, and R. R. WOLFE. Effect of exercise and recovery on muscle protein synthesis in human subjects. Am. J. Physiol. 259:E470-E476, 1990.
3. CALDER, A. G., S. E. ANDERSON, I. GRANT, M. A. MCNURLAN, and P. J. GARLICK. The determination of low d5-phenylalanine enrichment (0.002-0.09 atom percent excess) after conversion to phenylethylamine, in relation to protein turnover studies by gas chromatography/electron ionization mass spectrometry. Rapid Commun. Mass Spectrom. 6:421-424, 1992.
4. CASO, G., B. TYNDALL, D. SASVARY, G. CASELLA, and P. J. GARLICK. Muscle protein synthesis is depressed by acute respiratory acidosis. FASEB J. 14:A768, 2000.
5. CASO, G., B. A. GARLICK, G. A. CASELLA, D. SASVARY, and P. J. GARLICK. Acute metabolic acidosis inhibits muscle protein synthesis in rats. Am. J. Physiol. 287:E90-E96, 2004.
6. DOHM, G. L., G. J. KASPEREK, E. B. TAPSCOTT, and G. R. BEECHER. Effect of exercise on synthesis and degradation of muscle protein. Biochem. J. 188:255-262, 1980.
7. FERRETTI, G., H. HAUSER, and P. E. DI PRAMPERO. Maximal muscular power before and after exposure to chronic hypoxia. Int. J. Sports Med. 11(Suppl 1):S31-S34, 1990.
8. FULLER, S. J., C. J. GAITANAKI, and S. H. SUDGEN. Effects of increasing extracellular pH on protein synthesis and protein degradation in the perfused working rat heart. Biochem. J. 259:173-179, 1989.
9. GARLICK, P. J., I. GRANT, and R. T. GLENNIE. Short-term effects of corticosterone treatment on muscle protein synthesis in relation to feeding. Biochem. J. 248:439-442, 1987.
10. GARLICK, P. J. The role of leucine in the regulation of protein metabolism. J. Nutr. 135:1553S-1556S, 2005.
11. GRIFFITHS, R. D., T. E. A. PALMER, T. HELLIWELL, P. MACLENNAN, and R. R. MACMILLAN. Effect of passive stretching on the wasting of muscle in the critically ill. Nutrition 11:428-432, 1995.
12. HOPPELER, H., and D. DESPLANCHES. Muscle structural modifications in hypoxia. Int. J. Sports Med. 13(Suppl 1):S166-S168, 1992.
13. IMOBERDORF, R., P. J. GARLICK, M. A. MCNURLAN, et al. Enhanced synthesis of albumin and fibrinogen at high altitude. J. Appl. Physiol. 90:528-537, 2001.
14. KAYSER, B. Nutrition and high altitude exposure. Int. J. Sports Med. 13(Suppl 1):S129-132, 1992.
15. KAYSER, B., K. ACHESON, J. DECOMBAZ, E. FERN, and P. CERRETELLI. Protein absorption and energy digestibility at high altitude. J. Appl. Physiol. 73:2425-2431, 1992.
16. KLEGER, J. R., M. TURGAY, R. IMOBERDORF, M. A. MCNURLAN, P. J. GARLICK, and P. E. BALLMER. Acute metabolic acidosis decreases muscle protein synthesis but not albumin synthesis in humans. Am. J. Kidney Dis. 38:1199-1207, 2001.
17. LAUBER, K. Photometric determination of nitrogen. Wet incineration followed by formation of indophenol blue with salicylate/ hypochlorite. Clin. Chim. Acta 67:107-110, 1976.
18. MACDOUGALL, J. D., M. J. GIBALA, M. A. TARNOPOLSKY, J. R. MACDONALD, S. A. INTERISANO, and K. E. YARASHESKI. The time course for elevated muscle protein synthesis following heavy resistance exercise. Can. J. Appl. Physiol. 20:480-486, 1995.
19. MCGRATH, J. A., and D. F. GOLDSPINK. Glucocorticoid action on protein synthesis and protein breakdown in isolated skeletal muscles. Biochem. J. 206:641-645, 1982.
20. MCNURLAN, M. A., P. ESSEN, S. D. HEYS, V. BUCHNAN, P. J. GARLICK, and J. WERNERMANN. Measurement of protein synthesis in human skeletal muscle: Further investigation of the flooding technique. Clin. Sci. 81:557-564, 1991.
21. 5ring]phenylalanine. Am. J. Physiol. 267:102-108, 1994.
22. MORRISON, W. L., J. N. A. GIBSON, C. SCRIMGEOUR, and M. J. RENNIE. Muscle wasting in emphysema. Clin. Sci. 75:415-420, 1988.
23. MUSSINI, E., L. COLOMBO, G. DEPONTE, M. CALZI, and F. MARCUCCI. Effect of swimming on protein degradation: 3-mehtylhistidine and creatinine excretion. Biochem. Med. 34:373-375, 1985.
24. PHILLIPS, S. M., K. D. TIPTON, A. AARSLAND, and S. E. WOLF, and R. R. WOLFE. Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am. J. Physiol. 273:99-107, 1997.
25. PLANTE, P. D., and M. E. HOUSTON. Effects of concentric and eccentric exercise on protein catabolism in man. Int. J. Sports Med. 5:E174-E178, 1984.
26. PLANTE, R. I., and M. E. HOUSTON. Exercise and protein catabolism in women. Ann. Nutr. Metab. 28:123-129, 1984.
27. PREEDY, V. R., D. M. SMITH, and P. H. SUGDEN. The effects of 6 hours of hypoxia on protein synthesis in rat tissues in vivo and in vitro. Biochem. J. 228:179-185, 1985.
28. PREEDY, V. R., and P. H. SUGDEN. The effects of fasting or hypoxia on rates of protein synthesis in vivo in subcellular fractions of rat heart and gastrocnemius muscle. Biochem. J. 257:519-527, 1989.
29. RADHA, E., and S. P. BESSMAN. Effect of exercise on protein degradation: 3-methylhistidine and creatinine excretion. Biochem. Med. 29:96-100, 1983.
30. RANNELS, S. R., D. E. RANNELS, A. L. PEGG, and L. S. JEFFERSON. Glucocorticoid effects on peptide-chain initiation in skeletal muscle and heart. Am. J. Physiol. 235:E134-E139, 1978.
31. RANNELS, S. R., and L. S. JEFFERSON. Effects of glucocorticoids on muscle protein turnover in perfused rat hemicorpus. Am. J. Physiol. 238:E564-E572, 1980.
32. REEDS, P. J., and R. M. PALMER. Changes in prostaglandin release associated with inhibition of muscle protein synthesis by dexamethasone. Biochem. J. 219:953-957, 1984.
33. RENNIE, M. J., P. BABIJ, J. R. SUTTON, et al. Effects of acute hypoxia on forearm leucine metabolism. Prog. Clin. Biol. Res. 136:317-323, 1983.
34. RENNIE, M. J., and D. J. MILLWARD. 3-methylhistidine excretion and the urinary 3-methylhistidine/creatinine ratio are poor indicators of skeletal muscle protein breakdown. Clin. Sci. 65:217-225, 1983.
35. RENNIE, M. J., and K. D. TIPTON. Protein and amino acid metabolism during and after exercise and the effects of nutrition. Annu. Rev. Nutr. 20:457-483, 2000.
36. ROSE, M. S., C. S. HOUSTON, C. S. FULCO, G. COATES, J. R. SUTTON, and A. CYBERMAN. Operation Everest II: Nutrition and body composition. J. Appl. Physiol. 65:2545-2551, 1988.
37. SHEFFIELD-MOORE, M., C. W. YECKEL, E. VOLPI, et al. Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise. Am. J. Physiol. Endocrinol. Metab. 287:E513-E522, 2004.
38. SOUTHORN, B. G., R. M. PALMER, and P. J. GARLICK. Acute effects of corticosterone on tissue protein synthesis and insulin-sensitivity in rats in vivo. Biochem. J. 272:187-191, 1990.
39. TIPTON, K. D., A. A. FERRANDO, B. D. WILLIAMS, and R. R. WOLFE. Muscle protein metabolism in female swimmers after a combination of resistance and endurance exercise. J. Appl. Physiol. 81:2034-2038, 1996.
40. VOSSWINKEL, J. A., C. E. BRATHWAITE, T. R. SMITH, J. M. FERBER, G. CASELLA, and P. J. GARLICK. Hyperventilation increases muscle protein synthesis in critically ill trauma patients. J. Surg. Res. 91:61-64, 2000.
41. WARD, M. P., J. S. MILLEDGE, and J. B. WEST. High Altitude Medicine and Physiology, 3rd ed. London: Arnold, Hodder Headline Group, 2000, pp. 186-189.
42. WOLFE, R. R. Protein supplements and exercise. Am. J. Clin. Nutr. 72(Suppl):551-557, 2000.