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Materials and methods are available as supporting material on Science Online.
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We thank for financial support the National Science Foundation (NSF) and Army Research Office (ARO, to Y.L, the Air Force Office of Scientific Research, Office of Naval Research, NSF, Alfred P. Sloan Fellowship, ARO, and NIH (to H.Y, and Technology and Research Institute Funds funds from Arizona State University (to H.Y. and Y.L, Some of the work presented here was conducted at the National Resource for Automated Molecular Microscopy, which is supported by NIH though the National Center for Research Resources' P41 program (RR17573, We thank C. Potter and B. Carragher for helpful discussion and technical advice on the electron tomography work. IMOD software (Boulder Laboratory for 3D Electron Microscopy of Cells, Boulder, CO) used for tomographic reconstruction is supported by NIH grant P41 RR000592. 3D graphic images were produced using the University of California, San Francisco (UCSF) Chimera package from the Resource for Biocomputing, Visualization, and Informatics at UCSF
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We thank for financial support the National Science Foundation (NSF) and Army Research Office (ARO) (to Y.L.), the Air Force Office of Scientific Research, Office of Naval Research, NSF, Alfred P. Sloan Fellowship, ARO, and NIH (to H.Y.), and Technology and Research Institute Funds funds from Arizona State University (to H.Y. and Y.L.). Some of the work presented here was conducted at the National Resource for Automated Molecular Microscopy, which is supported by NIH though the National Center for Research Resources' P41 program (RR17573). We thank C. Potter and B. Carragher for helpful discussion and technical advice on the electron tomography work. IMOD software (Boulder Laboratory for 3D Electron Microscopy of Cells, Boulder, CO) used for tomographic reconstruction is supported by NIH grant P41 RR000592. 3D graphic images were produced using the University of California, San Francisco (UCSF) Chimera package from the Resource for Biocomputing, Visualization, and Informatics at UCSF (supported by NIH grant P41 RR-01081). We thank M. Palmer for technical assistance. We acknowledge the use of the EM facility in the School of Life Sciences at Arizona State University. We thank C. Lin for assistance in schematic figure drawings and Y. Ke for assistance in creating movies from the tomography reconstructions. We thank C. Flores for help proofreading the manuscript.
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