Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1 -transformed T cells

Journal of Leukocyte Biology

Volumn 85, Issue 1, 2009, Pages 165-174

  Nakase, Koichi ^a   Cheng, Jihua ^a   Zhu, Quan ^a   Marasco, Wayne A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Adult T cell leukemia; DNA methylation; Leukemogenesis

Indexed keywords

CD4 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEOXYRIBONUCLEASE; DEOXYRIBONUCLEASE I; DNA; FIBRINOGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE 15; MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR; OCTAMER TRANSCRIPTION FACTOR 1; PROTEIN; PROTEIN P2; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP; RNA POLYMERASE II; SRC HOMOLOGY DOMAIN 2 CONTAINING PROTEIN TYROSINE PHOSPHATASE 1; SYNAPSIN I; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BIOLOGY; CD4+ T LYMPHOCYTE; CELL COMMUNICATION; CELL CULTURE; CELL TRANSFORMATION; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; DISSOCIATION; DNA FOOTPRINTING; DNA METHYLATION; DOWN REGULATION; DRUG BINDING; GEL MOBILITY SHIFT ASSAY; GENE SILENCING; HEMATOLOGIC MALIGNANCY; HEMATOLOGY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LEUKEMIA CELL LINE; LEUKEMOGENESIS; LEUKOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE; TAX; TUMOR; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; CPG ISLANDS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA METHYLATION; GENE EXPRESSION REGULATION; GENE SILENCING; HEMATOPOIESIS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; MOLECULAR SEQUENCE DATA; NF-KAPPA B; OCTAMER TRANSCRIPTION FACTOR-1; PROMOTER REGIONS, GENETIC; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; RNA POLYMERASE II; SP1 TRANSCRIPTION FACTOR; T-LYMPHOCYTES;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 58149216407     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0608383     Document Type: Article

References (36)

1. Ostman, A., Hellberg. C., Bohmer. F. D. (2006) Protein-tyrosine phosphatases and cancer. Nat. Rev. Cancer 6, 307-320.
2. Ostman. A., Bohmer. F. D. (2001) Regulation of receptor tyrosine kinase signaling by protein lyrosine phosphalases. Trends Cell Biol. 11, 258-266.
3. Plulzky. J., Neel, B. G., Rosenberg, R. D., Eddy, R. L., Byers, M. G., Jani-Sait, S., Shows, T. B. (1992) Chromosomal localization of an SH2-containing tyrosine phosphatase (PTP6). Genomics 13, 869-872.
4. Yi, T. L., Cleveland, J. L., Ihle, J. N. (1992) Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. Mol. Cell. Biol. 12, 836-846.
5. Tsui. H. W., Hasselblatt. K., Martin, A., Mok, S. C., Tsur, F. W. (2002) Molecular mechanisms underlying SHP-1 gene expression. Ear. J. Biochem. 269, 3057-3064.
6. Paling, N. R., Welham. M. J. (2005) Tyrosine phosphatase SHP-1 acts at different stages of development to regulate hemalopoiesis. Blood 105, 4290-4297.
7. Cheng, J., Kydd. A. R., Nakase. K., Noonan. K. M., Murakami, A., Tao, H., Dwyer, M., Xu. C., Zhu, Q., Marasco, W. A. (2007) Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein. Blood 110, 2110-2120.
8. Wlodarski, P., Zhang, Q., Liu, X., Kasprzyeka, M., Marzec, M., Wasik. M. A. (2007) PU.1 activates transcription of SHP-1 gene in hematopoietic cells. J. Biol. Chem. 282, 6316-6323.
9. Zhang. Q., Raghunath, P. N., Vonderheid, E., Odum, N., Wasik, M. A. (2000) Lack of phosphotyrosine phosphatase SHP-1 expression in malig nant T-cell lymphoma cells results from methylation of the SHP-1 promoter. Am. J. Pathol. 157, 1137-1146.
10. Oka, T.,. Yoshmo, T., Hayashi, K., Ohara, N., Nakamshi, T., Yamaai, Y., Hiraki. A., Sogawa, C. A., Kondo, E., Teramoto, JN., Takahashi. K., Tsuchiyama, J., Akagi. T. (2001) Reductron of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene eKpression in natural killer cell lymphoma and various types of lymphomas/leukemias: combination analysis with cDNA expression array and tissue microarray. Am. J. Pathol. 159, 1495-1505.
11. Oka, T., Ouchida. M., Koyama. M., Ogama, Y., Takada, S., Nakatani, Y., Tanaka, T., Yoshino. T., Hayashi. K., Ohara, N., Kondo, F., Takahashi. K., Tsuchiyama, J., Tanimoto, M., Shimizu. K., Akagi, T. (2002) Gene silencing of the tyrosine phosphalase SHP1 gene by aberrant methylation in leukernias/lymphomas. Cancer Res. 62, 6390-6394.
12. Chim, C. S., Fung, T. K., Cheung, W. C. Liang. R., Kwong. Y. L. (2004) SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. Blood 103, 4630-4635.
13. Mena-Duran, A. V., Togo, S. H., Bazhenova, L., Cervera, J., Bethel, K., Senent. M. L., Mieva, J., Sanz. G. F., Sanz. M. A., Saven. A., Mustelin, T. (2005) SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic factor. Br. J. Haematol. 129, 791-794.
14. Delibrias. C. C., Floeltmann, J. E., Rowe, M., Fearon, D. T. (1997) Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes. J. Exp. Med. 186, 1575-1583.
15. Leon, F., Cespon. C., Franco, A., Lombardia, M., Roldan. E., Escribano. L., Harto, A., Gonzalez-Porque, P., Roy. G. (2002) SHP-1 expression in peripheral T cells from patients with Sezary syndrome and in the T cell line HUT-78: implications in JAK3-medialed signaling. leukemia 16, 1470-1477.
16. Amin. H. M., Hoshino, K., Yang, H., Lin. Q., Lai. R., Garcia-Manero, G. (2007) Decreased expression level of SH2 domain-containing protein tyrosine phosphatase-1 (Shpl) is associated with progression of chronic myeloid leukemia. J. Pathol. 212, 402-410.
17. Wu, C., Sun. M., Liu, L., Zhou. G. W. (2003) The function of the protein tyrosine phosphatase SHP-1 in cancer. Gene 306, 1 - 12.
18. Beghini, A., Ripamonti, C. B., Peterlongo, P., Roversi, G., Cairoli, R., Morra, E., Larizza, L. (2000) RJNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia. Hum. Mol. Genet. 9, 2297-2304.
19. Jin, Y. J., Yu, C. L., Burakoff, S. J. (1999) Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-termmal structure and catalytic activity. J. Biol. Chem. 274, 28301-28307.
20. Ma, X. Z., Jin, T., Sakac, D., Fahim, S., Zhang. X., Kalsman, Y., Bali, M., Branch, D. R. (2003) Abnormal splicing of SHP-1 protein tyrosine phosphatase in human T cells. Implications for lymphomagenesis. Exp. Hematol. 31, 131-142.
21. Cheng, J., Zhang, D., Zhou. C., Marasco, W. A. (2004) Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transiormed human peripheral blood CD4+ T-cells. Leuk. Res. 28, 71-82.
22. Koyama, M., Oka, T., Ouchida, M., Nakatani, Y., Nishiuchi. R., Yoshino. T., Hayashi, K., Akagi, T., Seino, Y. (2003) Activated proliferation of B-cell lymphomas/leukemias with the SHP1 gene silencing by aberrant CpG methylalion. Lab. Invest. 83, 1849-1858.
23. Chim, C. S., Wong, A. S., Kwong, Y. L. (2004) Epigenelic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukemias. Ann. Hematol. 83, 527-532.
24. Khoury, J. D., Rassidakis, G. Z., Medeiros, L. J., Amin, H. M., Lai, R. (2004) Melhylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma. Blood 104, 1580-1581.
25. Johan. M. F., Bowen. D. T., Frew, M. F., Goodeve, A. C., Reilly. J. T. (2005) Aberrant methylalion of the negative regulators RASSF1A, SHP-1 and SOCS-1 in myelodysplastic syndromes and acute myeloid leukemia. Br. J. Haematol. 129, 60-65.
26. Ruchusalsawal. K., Wongpiyabovorn, J., Shuangshoti, S., Hirankarn, N., Mulirangura, A. (2006) SHP-1 prornoter 2 melhylation in normal epithelial tissues and demethyiation in psoriasis. J. Mol. Med. 84, 175-182.
27. Zhang. Q., Wang, H. Y., Marzec, M., Raghunath, P. N., Nagasawa, T., Wasik, M. A. (2005) STAT3- and DNA melhyllransferase 1-mediated epigenetic silencing of SHP-1 lyrosine phosphalase tumor suppressor gene in malignant T lymphocytes. Proc. Natl. Acad. Scl. USA 102, 6948 -6953.
28. Nagasawa, T., Zhang, Q., Raghunath, P. N., Wong, H. Y., El-Salem, M., Szallasi. A., Marzec, M., Gimotty, P., Rook, A. H., Vonderheid, E. C., Odum, N., Wasik, M. A. (2006) Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells: delayed expression of the p16 prolein upon reversal of the silencing. Leuk. Res. 30, 303-312.
29. Nakase, K., Hara, M., Kozuka. T., Tanimoto. K., Nawa, Y. (2006) Bone marrow transplantation from unrelated donors for patients with adult T-cell leukemia/lymphoma. Bone Marrow Transplant. 37, 41-44.
30. Azran. I., Schavinsky-Khrapunsky, Y., Aboud, M. (2004) Role of Tax prolein in human T-cell leukemia virus lype-1 leukemogenicily. Retrovirology 1, 20.
31. Migone, T. S., Cacalano, N. A., Taylor. N., Yi, T., Waldmann, T. A., Johnston, J. A. (1998) Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor"; loss of SHP-1 expression in human T-lymphotropic virus type 1-transformed T cells. Proc. Natl. Acad. Sci. USA 95, 3845-3850.
32. Mori, N., Fujii, M., Ikeda, S., Yamada, Y., Tomonaga. M., Ballard, D. W., Yamamoto, N. (1999) Constilulive activation of NF-κB in primary adult T-cell leukemia cells. Blood 93, 2360-2368.
33. Braun, T., Carvalho, G., Fabre, C., Grosjean, J., Fenaux, P., Kroemer, G. (2006) Targeting NF-κB in hematologic malignancies. Cell Death Differ. 13, 748-758.
34. Kastner, P., Chan, S. (2008) PU. 1: a crucial and versatile player in hematopoiesis and leukemia. Int. J. Biochem. Cell Biol. 40, 22-27.
35. Ushijima, T. (2005) Detection and interpretation of altered methylation patterns in cancer cells. Nat. Rev. Cancer 5, 223-231.
36. Robertson, K. D. (2002) DNA methylation and chromatin-unraveling the tangled web. Oncogene 21, 5361-5379.