Treatment protocol of infections of orthopedic devices

Biofilms, Infection, and Antimicrobial Therapy

Volumn , Issue , 2005, Pages 449-478

  Antonios, Vera ^a   Berbari, Elie ^a   Osmon, Douglas ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 58149203846     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (186)

1. Allen, D.M., Orthopaedic implant infections: current management strategies. Ann. Acad. Med. Singapore 26, 687-690, 1997.
2. Jansen, B., and Peters, G., Foreign body associated infection. J. Antimicrob. Chemother. 32 Suppl A, 69-75, 1993.
3. Steckelberg, J., and Osmon, D.R., Prosthetic joint infections. In: Bisno, A.L., and Waldvogel, F.A., eds., Infections Associated with Indwelling Medical Devices. 3rd edition. Washington: American Society for Microbiology, 2000:173-209.
4. Berbari, E.F., Hanssen, A.D., Duffy, M.C., et al., Risk factors for prosthetic joint infection: case-control study. Clin. Infect. Dis. 27, 1247-1254, 1998.
5. Carlsson, A.K., Lidgren, L., and Lindberg, L., Prophylactic antibiotics against early and late deep infections after total hip replacements. Acta. Orthop. Scand. 48, 405-410, 1977.
6. Dougherty, S.H., Pathobiology of infection in prosthetic devices. [comment]. Rev. Infect. Dis. 10, 1102-1117, 1988.
7. Gristina, A.G., and Costerton, J.W., Bacterial adherence to biomaterials and tissue. The significance of its role in clinical sepsis. J. Bone Joint Surg. Am. 67, 264-273, 1985.
8. Costerton, J.W., Stewart, P.S., and Greenberg, E.P., Bacterial biofilms: a common cause of persistent infections. Science 284, 1318-1322, 1999.
9. Gristina, A.G., and Kolkin, J., Current concepts review. Total joint replacement and sepsis. J. Bone Joint Surg. Am. 65, 128-134, 1983.
10. Khardori, N., and Yassien, M., Biofilms in device-related infections. J. Ind. Microbiol. 15, 141-147, 1995.
11. Trampuz, A.P.K., Mandrekar, J., Greenleaf, J.F., Steckelberg, J.M., and Patel, R., Comparison of scraping, sonication and vortexing for removal of Staphylococcus epidermidis biofilms from polycarbonate coupons. American Society for Microbiology Conference on Biofilms, Nov. 1-6, 2003, Victoria, Canada.
12. Nguyen, L.L., Nelson, C.L., Saccente, M., Smeltzer, M.S., Wassell, D.L., and McLaren, S.G., Detecting bacterial colonization of implanted orthopaedic devices by ultrasonication. Clin. Orthop. 403, 29-37, 2002.
13. Tunney, M.M., Patrick, S., Curran, M.D., et al., Detection of prosthetic hip infection at revision arthroplasty by immunofluorescence microscopy and PCR amplification of the bacterial 16S rRNA gene. J. Clin. Microbiol. 37, 3281-3290, 1999.
14. Tunney, M.M., Patrick, S., Gorman, S.P., et al., Improved detection of infection in hip replacements. A currently underestimated problem. J. Bone Joint Surg. Br. 80, 568-572, 1998.
15. Hanssen, A.D., and Osmon, D.R., Evaluation of a staging system for infected hip arthroplasty. Clin. Orthop. 403, 16-22, 2002.
16. McPherson, E.J., Tontz, W., Jr., Patzakis, M., et al., Outcome of infected total knee utilizing a staging system for prosthetic joint infection. Am. J. Orthop. 28, 161-165, 1999.
17. McPherson, E.J., Woodson, C., Holtom, P., Roidis, N., Shufelt, C., and Patzakis, M., Periprosthetic total hip infection: outcomes using a staging system. Clin. Orthop. 403, 8-15, 2002.
18. Tsukayama, D.T., Goldberg, V.M., and Kyle, R., Diagnosis and management of infection after total knee arthroplasty. J. Bone Joint Surg. Am. 85-A Suppl 1, S75-S80, 2003.
19. Tsukayama, D.T., Estrada, R., and Gustilo, R.B., Infection after total hip arthroplasty. A study of the treatment of one hundred and six infections. J. Bone Joint Surg. Am. 78, 512-523, 1996.
20. Cierny, G., 3rd, and DiPasquale, D., Periprosthetic total joint infections: staging, treatment, and outcomes. Clin. Orthop. 23-28, 2002.
21. Trampuz, A., Osmon, D.R., Hanssen, A.D., Steckelberg, J.M., and Patel, R., Molecular and antibiofilm approaches to prosthetic joint infection. Clin. Orthop. 69-88, 2003.
22. Fisman, D.N., Reilly, D.T., Karchmer, A.W., and Goldie, S.J., Clinical effectiveness and cost-effectiveness of 2 management strategies for infected total hip arthroplasty in the elderly. [comment]. Clin. Infect. Dis. 32, 419-430, 2001.
23. Johnson, D.P., and Bannister, G.C., The outcome of infected arthroplasty of the knee. J. Bone Joint Surg. Br. 68, 289-291, 1986.
24. Tsukayama, D.T., Wicklund, B., and Gustilo, R.B., Suppressive antibiotic therapy in chronic prosthetic joint infections. Orthopedics 14, 841-844, 1991.
25. Canner, G.C., Steinberg, M.E., Heppenstall, R.B., and Balderston, R., The infected hip after total hip arthroplasty. J. Bone Joint Surg. Am. 66, 1393-1399, 1984.
26. Segreti, J., Nelson, J.A., and Trenholme, G.M., Prolonged suppressive antibiotic therapy for infected orthopedic prostheses [comment]. Clin. Infect. Dis. 27, 711-713, 1998.
27. Goulet, J.A., Pellicci, P.M., Brause, B.D., and Salvati, E.M., Prolonged suppression of infection in total hip arthroplasty. J. Arthroplasty 3, 109-116, 1988.
28. Tattevin, P., Cremieux, A.C., Pottier, P., Huten, D., and Carbon, C., Prosthetic joint infection: when can prosthesis salvage be considered? [comment]. Clin. Infect. Dis. 29, 292-295, 1999.
29. Mont, M.A., Waldman, B., Banerjee, C., Pacheco, I.H., and Hungerford, D.S., Multiple irrigation, debridement, and retention of components in infected total knee arthroplasty. J. Arthroplasty 12, 426-433, 1997.
30. Zimmerli, W., Widmer, A.F., Blatter, M., Frei, R., and Ochsner, P.E., Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group [comment]. JAMA 279, 1537-1541, 1998.
31. Segawa, H., Tsukayama, D.T., Kyle, R.F., Becker, D.A., and Gustilo, R.B., Infection after total knee arthroplasty. A retrospective study of the treatment of eighty-one infections. J. Bone Joint Surg. Am. 81, 1434-1445, 1999.
32. Brandt, C.M., Sistrunk, W.W., Duffy, M.C., et al., Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention. Clin. Infect. Dis. 24, 914-919, 1997.
33. Crockarell, J.R., Hanssen, A.D., Osmon, D.R., and Morrey, B.F., Treatment of infection with debridement and retention of the components following hip arthroplasty. J. Bone Joint Surg. Am. 80, 1306-1313, 1998.
34. Meehan, A.M., Osmon, D.R., Duffy, M.C., Hanssen, A.D., and Keating, M.R., Outcome of penicillin-susceptible streptococcal prosthetic joint infection treated with debridement and retention of the prosthesis. Clin. Infect. Dis. 36, 845-849, 2003.
35. Marculescu, C., Berbari, E., Hanssen, A., Harmsen, S., Mandrekar, J., Steckelberg, J., and Osmon, D., Outcome of PJI treated with debridement and retention of components. Infectious Diseases Society of America, Oct. 9-12, 2003, San Diego, California.
36. Zimmerli, W., and Ochsner, P.E., Management of infection associated with prosthetic joints. Infection 31, 99-108, 2003.
37. Kantor, G.S., Osterkamp, J.A., Dorr, L.D., Fischer, D., Perry, J., and Conaty, J.P., Resection arthroplasty following infected total hip replacement arthroplasty. J. Arthroplasty 1, 83-89, 1986.
38. Grauer, J.D., Amstutz, H.C., O’Carroll, P.F., and Dorey, F.J., Resection arthroplasty of the hip. J. Bone Joint Surg. Am. 71, 669-678, 1989.
39. McElwaine, J.P., and Colville, J., Excision arthroplasty for infected total hip replacements. J. Bone Joint Surg. Br. 66, 168-171, 1984.
40. Bittar, E.S., and Petty, W., Girdlestone arthroplasty for infected total hip arthroplasty. Clin. Orthop. 83-87, 1982.
41. Falahee, M.H., Matthews, L.S., and Kaufer, H., Resection arthroplasty as a salvage procedure for a knee with infection after a total arthroplasty. J. Bone Joint Surg. Am. 69, 1013-1021, 1987.
42. Elson, R., One-stage exchange in the treatment of the infected total hip arthroplasty. Semin. Arthroplasty 5, 137-141, 1994.
43. Callaghan, J.J., Katz, R.P., and Johnston, R.C., One-stage revision surgery of the infected hip. A minimum 10-year followup study. Clin. Orthop. 139-143, 1999.
44. Ure, K.J., Amstutz, H.C., Nasser, S., and Schmalzried, T.P., Direct-exchange arthroplasty for the treatment of infection after total hip replacement. An average ten-year follow-up. J. Bone Joint Surg. Am. 80, 961-968, 1998.
45. Raut, V.V., Siney, P.D., and Wroblewski, B.M., One-stage revision of total hip arthroplasty for deep infection. Long-term followup. Clin. Orthop. 202-207, 1995.
46. Hanssen, A.D., and Osmon, D.R., Assessment of patient selection criteria for treatment of the infected hip arthroplasty. Clin. Orthop. 91-100, 2000.
47. Raut, V.V., Orth, M.S., Orth, M.C., Siney, P.D., and Wroblewski, B.M., One stage revision arthroplasty of the hip for deep gram negative infection. Int. Orthop. 20, 12-14, 1996.
48. Raut, V.V., Siney, P.D., and Wroblewski, B.M., One-stage revision of infected total hip replacements with discharging sinuses. J. Bone Joint Surg. Br. 76, 721-724, 1994.
49. Goksan, S.B., and Freeman, M.A., One-stage reimplantation for infected total knee arthroplasty. J. Bone Joint Surg. Br. 74, 78-82, 1992.
50. Silva, M., Tharani, R., and Schmalzried, T.P., Results of direct exchange or debridement of the infected total knee arthroplasty. Clin. Orthop. 125-131, 2002.
51. Brandt, C.M., Duffy, M.C., Berbari, E.F., Hanssen, A.D., Steckelberg, J.M., and Osmon, D.R., Staphylococcus aureus prosthetic joint infection treated with prosthesis removal and delayed reimplantation arthroplasty. Mayo. Clin. Proc. 74, 553-558, 1999.
52. Haddad, F.S., Muirhead-Allwood, S.K., Manktelow, A.R., and Bacarese-Hamilton, I., Two-stage uncemented revision hip arthroplasty for infection. J. Bone Joint Surg. Br. 82, 689-694, 2000.
53. Fehring, T.K., Calton, T.F., and Griffin, W.L., Cementless fixation in 2-stage reimplantation for periprosthetic sepsis. J. Arthroplasty 14, 175-181, 1999.
54. Rand, J.A., and Bryan, R.S., Reimplantation for the salvage of an infected total knee arthroplasty. J. Bone Joint Surg. Am. 65, 1081-1086, 1983.
55. McPherson, E., Periprosthetic total knee infection. In: Calhoun, J.H., and Mader, J.T., eds., Musculoskeletal Infections. New York: Marcel Dekker, 2003:293-324.
56. Hirakawa, K., Stulberg, B.N., Wilde, A.H., Bauer, T.W., and Secic, M., Results of 2-stage reimplantation for infected total knee arthroplasty. J. Arthroplasty, 13, 22-28, 1998.
57. McPherson, E.J., Patzakis, M.J., Gross, J.E., Holtom, P.D., Song, M., and Dorr, L.D., Infected total knee arthroplasty. Two-stage reimplantation with a gastrocnemius rotational flap. Clin. Orthop. 73-81, 1997.
58. Mont, M.A., Waldman, B.J., and Hungerford, D.S., Evaluation of preoperative cultures before second-stage reimplantation of a total knee prosthesis complicated by infection. A comparison-group study [comment]. J. Bone Joint Surg. Am. 82-A, 1552-1557, 2000.
59. Hanssen, A.D., Rand, J.A., and Osmon, D.R., Treatment of the infected total knee arthroplasty with insertion of another prosthesis. The effect of antibiotic-impregnated bone cement. Clin. Orthop. 44-55, 1994.
60. Teeny, S.M., Dorr, L., Murata, G., and Conaty, P., Treatment of infected total knee arthroplasty. Irrigation and debridement versus two-stage reimplantation. J. Arthroplasty 5, 35-39, 1990.
61. Rosenberg, A.G., Haas, B., Barden, R., Marquez, D., Landon, G.C., and Galante, J.O., Salvage of infected total knee arthroplasty. Clin. Orthop. 29-33, 1988.
62. Jhao, C., and Jiang, C.C., Two-stage reimplantation without cement spacer for septic total knee replacement. J. Formos. Med. Assoc. 102, 37-41, 2003.
63. Bengston S.K.K., The infected knee arthroplasty. A 6-year follow-up of 357 cases. Acta. Orthop. Scand. 62, 301-311, 1991.
64. Rand, J.A., Bryan, R.S., Morrey, B.F., and Westholm, F., Management of infected total knee arthroplasty. Clin. Orthop. 75-85, 1986.
65. Bengston, S., Knutson, K., and Lidgren, L., Treatment of infected knee arthroplasty. Clin. Orthop. 173-178, 1989.
66. Rand, J.A., Bryan, R.S., and Chao, E.Y., Failed total knee arthroplasty treated by arthrodesis of the knee using the Ace-Fischer apparatus. J. Bone Joint Surg. Am. 69, 39-45, 1987.
67. Donley, B.G., Matthews, L.S., and Kaufer, H., Arthrodesis of the knee with an intramedullary nail [comment]. J. Bone Joint Surg. Am. 73, 907-913, 1991.
68. Kaufer, H., and Matthews, L.S., Resection arthroplasty: an alternative to arthrodesis for salvage of the infected total knee arthroplasty. Instr. Course Lect. 35, 283-289, 1986.
69. Sierra, R.J., Trousdale, R.T., and Pagnano, M.W., Above-the-knee amputation after a total knee replacement: prevalence, etiology, and functional outcome. J. Bone Joint Surg. Am. 85-A, 1000-1004, 2003.
70. Isiklar, Z.U., Landon, G.C., and Tullos, H.S., Amputation after failed total knee arthroplasty. Clin. Orthop. 173-178, 1994.
71. Widmer, A.F., Frei, R., Rajacic, Z., and Zimmerli, W., Correlation between in vivo and in vitro efficacy of antimicrobial agents against foreign body infections. J. Infect. Dis. 162, 96-102, 1990.
72. Blaser, J., Vergeres, P., Widmer, A.F., and Zimmerli, W., In vivo verification of in vitro model of antibiotic treatment of device-related infection. Antimicrob. Agents Chemother. 39, 1134-1139, 1995.
73. Drancourt, M., Stein, A., Argenson, J.N., Zannier, A., Curvale, G., and Raoult, D., Oral rifampin plus ofloxacin for treatment of Staphylococcus-infected orthopedic implants. Antimicrob. Agents Chemother. 37, 1214-1218, 1993.
74. Widmer, A.F., Gaechter, A., Ochsner, P.E., and Zimmerli, W., Antimicrobial treatment of orthopedic implant-related infections with rifampin combinations. Clin. Infect. Dis. 14, 1251-1253, 1992.
75. Drancourt, M., Stein, A., Argenson, J.N., Roiron, R., Groulier, P., and Raoult, D., Oral treatment of Staphylococcus spp. infected orthopaedic implants with fusidic acid or ofloxacin in combination with rifampicin. J. Antimicrob. Chemother. 39, 235-240, 1997.
76. Razonable, R.R., Osmon, D.R., and Steckelberg, J.M., Linezolid therapy for orthopedic infections. Mayo Clin. Proc. 70, 1137-1144, 2004.
77. Mader, J.T., and Adams, K., Comparative evaluation of daptomycin (LY146032) and vancomycin in the treatment of experimental methicillin-resistant Staphylococcus aureus osteomyelitis in rabbits. Antimicrob. Agents Chemother. 33, 689-692, 1989.
78. Juthani-Mehta M.V.H., Gorelick, J., and Rappeport, J.M., Successful therapy of Methicillin-resistant Staphylococcus aureus (MRSA) vertebral osteomyelitis (VOM) with Daptomycin. Infectious Diseases Society of America, Oct. 9-12, 2003, San Diego, California
79. Williams, D.N., Rehm, S.J., Tice, A.D., Bradley, J.S., Kind, A.C., and Craig, W.A., Practice guidelines for community-based parenteral anti-infective therapy. ISDA Practice Guidelines Committee. Clin. Infect. Dis. 25, 787-801, 1997.
80. Heck, D., Rosenberg, A., Schink-Ascani, M., Garbus, S., and Kiewitt, T., Use of antibiotic-impregnated cement during hip and knee arthroplasty in the United States. J. Arthroplasty 10, 470-475, 1995.
81. Joseph, T.N., Chen, A.L., and Di Cesare, P.E., Use of antibiotic-impregnated cement in total joint arthroplasty. J. Am. Acad. Orthop. Surg. 11, 38-47, 2003.
82. www.stryker.com/orthopaedics/sites/bonecement/
83. www.biomet.com/products/index.cfm?p=090F06
84. Perry, A.C., Prpa, B., Rouse, M.S., et al., Levofloxacin and trovafloxacin inhibition of experimental fracture-healing. Clin. Orthop. 95-100, 2003.
85. Huddleston, P.M., Steckelberg, J.M., Hanssen, A.D., Rouse, M.S., Bolander, M.E., and Patel, R., Ciprofloxacin inhibition of experimental fracture healing. J. Bone Joint Surg. Am. 82, 161-173, 2000.
86. Silverberg, D., Kodali, P., Dipersio, J., Acus, R., and Askew, M., In vitro analysis of antifungal impregnated polymethylmethacrylate bone cement. Clin. Orthop. Relat. Res. 403, 228-231, 2002.
87. Hendriks, J.G., Neut, D., van Horn, J.R., van der Mei, H.C., and Busscher, H.J., The release of gentamicin from acrylic bone cements in a simulated prosthesis-related interfacial gap. J. Biomed. Mater. Res. 64B, 1-5, 2003.
88. Hofmann, A.A., Kane, K.R., Tkach, T.K., Plaster, R.L., and Camargo, M.P., Treatment of infected total knee arthroplasty using an articulating spacer. Clin. Orthop. 45-54, 1995.
89. Magnan, B., Regis, D., Biscaglia, R., and Bartolozzi, P., Preformed acrylic bone cement spacer loaded with antibiotics: use of two-stage procedure in 10 patients because of infected hips after total replacement. Acta. Orthop. Scand. 72, 591-594, 2001.
90. Emerson, R.H., Jr., Muncie, M., Tarbox, T.R., and Higgins, L.L., Comparison of a static with a mobile spacer in total knee infection. Clin. Orthop. 132-138, 2002.
91. Haddad, F.S., Masri, B.A., Garbuz, D.S., and Duncan, C.P., The treatment of the infected hip replacement. The complex case. Clin. Orthop. 144-156, 1999.
92. Springer B.J.D., Lee, G.C., Osmon, D., Haiukewych, G., Hanssen, A., and Jacofsky, D.J., Systemic safety of high dose antibiotic loaded cement spacers after resection of an infected total knee arthroplasty. Clin. Orthop. Relat. Res. 427, 47-51, 2004.
93. Trampuz A.H.A., Osmon, D.R., Piper, K.E., Rouse, M.S., Steckelberg, J.M., and Patel, R., The role of preoperative antimicrobial therapy on culture sensitivity of joint fluid, periprosthetic tissue, and explant sonicate in the diagnosis of prosthetic joint infection. Musculoskeletal Infection Society, 2003, Snowmass, Colorado.
94. Powles, J.W., Spencer, R.F., and Lovering, A.M., Gentamicin release from old cement during revision hip arthroplasty. J. Bone Joint Surg. Br. 80, 607-610, 1998.
95. von Eiff, C., Proctor, R.A., and Peters, G., Staphylococcus aureus small colony variants: formation and clinical impact. Int. J. Clin. Pract. Suppl. 44-49, 2000.
96. von Eiff, C., Proctor, R.A., and Peters, G., Small colony variants of Staphylococci: a link to persistent infections. Berl. Munch. Tierarztl. Wochenschr. 113, 321-325, 2000.
97. Proctor, R.A., van Langevelde, P., Kristjansson, M., Maslow, J.N., and Arbeit, R.D., Persistent and relapsing infections associated with small-colony variants of Staphylococcus aureus. Clin. Infect. Dis. 20, 95-102, 1995.
98. Looney, W.J., Small-colony variants of Staphylococcus aureus. Br. J. Biomed. Sci. 57, 317-322, 2000.
99. Pan, X.S., Hamlyn, P.J., Talens-Visconti, R., Alovero, F.L., Manzo, R.H., and Fisher, L.M., Small-colony mutants of Staphylococcus aureus allow selection of gyrase-mediated resistance to dual-target fluoroquinolones. Antimicrob. Agents Chemother. 46, 2498-2506, 2002.
100. Della Valle, C.J., Scher, D.M., Kim, Y.H., et al., The role of intraoperative Gram stain in revision total joint arthroplasty. J. Arthroplasty 14, 500-504, 1999.
101. Pandey, R., Drakoulakis, E., and Athanasou, N.A., An assessment of the histological criteria used to diagnose infection in hip revision arthroplasty tissues. J. Clin. Pathol. 52, 118-123, 1999.
102. Feldman, D.S., Lonner, J.H., Desai, P., and Zuckerman, J.D., The role of intraoperative frozen sections in revision total joint arthroplasty [comment]. J. Bone Joint Surg. Am. 77, 1807-1813, 1995.
103. Lonner, J.H., Desai, P., Dicesare, P.E., Steiner, G., and Zuckerman, J.D., The reliability of analysis of intraoperative frozen sections for identifying active infection during revision hip or knee arthroplasty. J. Bone Joint Surg. Am. 78, 1553-1558, 1996.
104. Della Valle, C.J., Bogner, E., Desai, P., et al., Analysis of frozen sections of intraoperative specimens obtained at the time of reoperation after hip or knee resection arthroplasty for the treatment of infection. J. Bone Joint Surg. Am. 81, 684-689, 1999.
105. Abdul-Karim, F.W., McGinnis, M.G., Kraay, M., Emancipator, S.N., and Goldberg, V., Frozen section biopsy assessment for the presence of polymorphonuclear leukocytes in patients undergoing revision of arthroplasties. Modern Pathology 11, 427-431, 1998.
106. Fehring, T.K., and McAlister, Jr. J.A., Frozen histologic section as a guide to sepsis in revision joint arthroplasty. Clin. Orthop. 229-237, 1994.
107. Banit, D.M., Kaufer, H., and Hartford, J.M., Intraoperative frozen section analysis in revision total joint arthroplasty. Clin. Orthop. 230-238, 2002.
108. Atkins, B.L., Athanasou, N., Deeks, J.J., et al., Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty. The OSIRIS Collaborative Study Group. J. Clin. Microbiol. 36, 2932-2939, 1998.
109. Marculescu, C., Berbari, E., Steckelberg, J., Hanssen, A., and Osmon, D., Medical treatment and outcome of clinically unsuspected prosthetic joint infection diagnosed by multiple positive cultures at the time of revision arthroplasty. Infectious Diseases Society of America, Oct. 9-12, 2003, San Diego, California.
110. Marculescu, C., Berbari, E., Hanssen, A., Steckelberg, J., and Osmon, D., Significance of acute inflammation in joint tissue at reimplantation arthroplasty in patients with prosthetic joint infectio treated with two-stage exchange. Infectious Diseases Society of America, Oct. 9-12, 2003, San Diego, California.
111. Bengston, S.K.K., and Lidgren, L., Revision of infected knee arthroplasty. Acta. Orthop. Scand. 57, 484-494, 1986.
112. Hanssen, A.D., Trousdale, R.T., and Osmon, D.R., Patient outcome with reinfection following reimplantation for the infected total knee arthroplasty. Clin. Orthop. 55-67, 1995.
113. Pagnano, M.W., Trousdale, R.T., and Hanssen, A.D., Outcome after reinfection following reimplantation hip arthroplasty. Clin. Orthop. 192-204, 1997.
114. Ross, J.J., Saltzman, C.L., Carling, P., and Shapiro, D.S., Pneumococcal septic arthritis: review of 190 cases. Clin. Infect. Dis. 36, 319-327, 2003.
115. Phelan, D.M., Osmon, D.R., Keating, M.R., and Hanssen, A.D., Delayed reimplantation arthroplasty for candidal prosthetic joint infection: a report of 4 cases and review of the literature. Clin. Infect. Dis. 34, 930-938, 2002.
116. Weil, Y., Mattan, Y., Liebergall, M., and Rahav, G., Brucella prosthetic joint infection: a report of 3 cases and a review of the literature. Clin. Infect. Dis. 36, e81-86, 2003.
117. Berbari, E.F., Hanssen, A.D., Duffy, M.C., Steckelberg, J.M., and Osmon, D.R., Prosthetic joint infection due to Mycobacterium tuberculosis: a case series and review of the literature. Am. J. Orthop. 27, 219-227, 1998.
118. Herold, R.C., Lotke, P.A., and MacGregor, R.R., Prosthetic joint infections secondary to rapidly growing Mycobacterium fortuitum. Clin. Orthop. 183-186, 1987.
119. Weiler, P.J., and Hastings, D.E., Listeria monocytogenes-an unusual cause of late infection in a prosthetic hip joint. J. Rheumatol. 17, 705-707, 1990.
120. Jellicoe, P.A., Cohen, A., and Campbell, P., Haemophilus parainfluenzae complicating total hip arthroplasty: a rapid failure. J. Arthroplasty 17, 114-116, 2002.
121. Iglesias, L., Garcia-Arenzana, J.M., Valiente, A., Gomariz, M., and Perez-Trallero, E., Yersinia enterocolitica O:3 infection of a prosthetic knee joint related to recurrent hemarthrosis. Scand. J. Infect. Dis. 34, 132-133, 2002.
122. Bates, C.J., Clarke, T.C., and Spencer, R.C., Prosthetic hip joint infection due to Campylobacter fetus [comment]. J. Clin. Microbiol. 32, 2037, 1994.
123. Fresard, A., Guglielminotti, C., Berthelot, P., et al., Prosthetic joint infection caused by Tropheryma whippelii (Whipple’s bacillus). Clin. Infect. Dis. 22, 575-576, 1996.
124. Maradona, J.A., Asensi, V., Carton, J.A., Rodriguez Guardado, A., and Lizon Castellano, J., Prosthetic joint infection by Pasteurella multocida. Eur. J. Clin. Microbiol. Infect. Dis. 16, 623-625, 1997.
125. McCarthy, J., and Stingemore, N., Clostridium difficile infection of a prosthetic joint presenting 12 months after antibiotic-associated diarrhoea. J. Infect. 39, 94-96, 1999.
126. Magerl, F., Wyss, A., Brunner, C., and Binder, W., Plate osteosynthesis of femoral shaft fractures in adults. A follow-up study. Clin. Orthop. 62-73, 1979.
127. Bach, A.W., and Hansen, Jr. S.T., Plates versus external fixation in severe open tibial shaft fractures. A randomized trial. Clin. Orthop. 89-94, 1989.
128. Lambiris, E., Tyllianakis, M., Megas, P., and Panagiotopoulos, E., Intramedullary nailing: experience in 427 patients. Bull. Hosp. Joint Dis. 55, 25-27, 1996.
129. Whittle, A.P., Russell, T.A., Taylor, J.C., and Lavelle, D.G., Treatment of open fractures of the tibial shaft with the use of interlocking nailing without reaming. J. Bone Joint Surg. Am. 74, 1162-1171, 1992.
130. Brumback, R.J., Ellison, P.S., Jr., Poka, A., Lakatos, R., Bathon, G.H., and Burgess, A.R., Intramedullary nailing of open fractures of the femoral shaft. J. Bone Joint Surg. Am. 71, 1324-1331, 1989.
131. Johner, R., and Wruhs, O., Classification of tibial shaft fractures and correlation with results after rigid internal fixation. Clin. Orthop. 7-25, 1983.
132. Ruedi, T.P., and Luscher, J.N., Results after internal fixation of comminuted fractures of the femoral shaft with DC plates. Clin. Orthop. 74-76, 1979.
133. Smith, J.E., Results of early and delayed internal fixation for tibial shaft fractures. A review of 470 fractures. J. Bone Joint Surg. Br. 56B:469-477, 1974.
134. Fischer, M.D., Gustilo, R.B., and Varecka, T.F., The timing of flap coverage, bone-grafting, and intramedullary nailing in patients who have a fracture of the tibial shaft with extensive soft-tissue injury. J. Bone Joint Surg. Am. 73, 1316-1322, 1991.
135. Collinge, C.A., and Sanders, R.W., Percutaneous plating in the lower extremity. J. Am. Acad. Orthop. Surg. 8, 211-216, 2000.
136. Winquist, R.A., Hansen, S.T., Jr., and Clawson, D.K., Closed intramedullary nailing of femoral fractures. A report of five hundred and twenty cases. J. Bone Joint Surg. Am. 66, 529-539, 1984.
137. Johnson, K.D., Johnston, D.W., and Parker, B., Comminuted femoral-shaft fractures: treatment by roller traction, cerclage wires and an intramedullary nail, or an interlocking intramedullary nail. J. Bone Joint Surg. Am. 66, 1222-1235, 1984.
138. Parameswaran, A.D., Roberts, C.S., Seligon, D., and Voor, M., Pin tract infection with contemporary external fixation: how much of a problem. J. Orthop. Trauma 17, 503-507, 2003.
139. Marshall, P.D., Saleh, M., and Douglas, D.L., Risk of deep infection with intramedullary nailing following the use of external fixators [comment]. J. R. Coll. Surg. Edinb. 36, 268-271, 1991.
140. Tornqvist, H., Tibia nonunions treated by interlocked nailing: increased risk of infection after previous external fixation. J. Orthop. Trauma 4, 109-114, 1990.
141. Bone, L.B., and Johnson, K.D., Treatment of tibial fractures by reaming and intramedullary nailing. J. Bone Joint Surg. Am. 68, 877-887, 1986.
142. Tornetta, P., 3rd, and Tiburzi, D., Reamed versus nonreamed anterograde femoral nailing. J. Orthop. Trauma. 14, 15-19, 2000.
143. Tornetta, P., 3rd, and Tiburzi, D., The treatment of femoral shaft fractures using intramedullary interlocked nails with and without intramedullary reaming: a preliminary report. J. Orthop. Trauma 11, 89-92, 1997.
144. Moed, B.R., and Watson, J.T., Retrograde nailing of the femoral shaft. J. Am. Acad. Orthop. Surg. 7, 209-216, 1999.
145. Moed, B.R., Watson, J.T., Cramer, K.E., Karges, D.E., and Teefey, J.S., Unreamed retrograde intramedullary nailing of fractures of the femoral shaft. J. Orthop. Trauma 12, 334-342, 1998.
146. Court-Brown, C.M., Will, E., Christie, J., and McQueen, M.M., Reamed or unreamed nailing for closed tibial fractures. A prospective study in Tscherne C1 fractures [comment]. J. Bone Joint Surg. Br. 78, 580-583, 1996.
147. Paley, D., and Herzenberg, J.E., Intramedullary infections treated with antibiotic cement rods: preliminary results in nine cases. J. Orthop. Trauma 16, 723-729, 2002.
148. Patzakis, M.J., Wilkins, J., and Wiss, D.A., Infection following intramedullary nailing of long bones. Diagnosis and management. Clin. Orthop. 182-191, 1986.
149. Court-Brown, C.M., Keating, J.F., and McQueen, M.M., Infection after intramedullary nailing of the tibia. Incidence and protocol for management. J. Bone Joint Surg. Br. 74, 770-774, 1992.
150. Emami, A., Mjoberg, B., and Larsson, S., Infected tibial nonunion. Good results after open cancellous bone grafting in 37 cases. Acta. Orthop. Scand. 66, 447-451, 1995.
151. Morandi, M., Zembo, M.M., and Ciotti, M., Infected tibial pseudarthrosis. A 2-year follow up on patients treated by the Ilizarov technique. Orthopedics 12, 497-508, 1989.
152. Shahcheraghi, G.H., and Bayatpoor, A., Infected tibial nonunion. Can. J. Surg. 37, 209-213, 1994.
153. Seligson, D., and Klemm, K., Treatment of infection following intramedullary nailing. In: Browner, B.D., ed., The science and practice of intramedullary nailing. Media, PA: Williams and Wilkins, 1996:317-333.
154. Klemm, K.H.S, and Seligson, D., The treatment of infection after interlocking nailing. Techniques Orthop. 3, 54-61, 1988.
155. Klemm, K.W., Treatment of infected pseudarthrosis of the femur and tibia with an interlocking nail. Clin. Orthop. 174-181, 1986.
156. Miller, M.E., Ada, J.R., and Webb, L.X., Treatment of infected nonunion and delayed union of tibia fractures with locking intramedullary nails. Clin. Orthop. 233-238, 1989.
157. Patzakis, M.J., Scilaris, T.A., Chon, J., Holtom, P., and Sherman, R., Results of bone grafting for infected tibial nonunion. Clin. Orthop. 192-198, 1995.
158. Ring, D., Jupiter, J.B., Gan, B.S., Israeli, R., Yaremchuk, M.J., Infected nonunion of the tibia. Clin. Orthop. Rel. Res. 369, 302-311, 1999.
159. Mahan, J., Seligson, D., Henry, S.L., Hynes, P., and Dobbins, J., Factors in pin tract infections. Orthopedics 14, 305-308, 1991.
160. Haleem, A.A., Rouse, M.S., Lewallen, D.G., Hanssen, A.D., Steckelberg, J.M., and Patel, R. Gentamicin and vancomycin do not impair experimental fracture healing. Clin. Orthop. Relat. Res. 427, 22-24, 2004.
161. Lonstein, J., Winter, R., Moe, J., and Gaines, D., Wound infection with Harrington instrumentation and spine fusion for scoliosis. Clin. Orthop. 96, 222-233, 1973.
162. Calderone, R.R., Garland, D.E., Capen, D.A., and Oster, H., Cost of medical care for postoperative spinal infections. Orthop. Clin. North Am. 27, 171-182, 1996.
163. Blam O.G., Vaccaro, A.R., Vanichkachorn, J.S., Albert, T.J., Hilibrand, A.S., Minnich, J.M., and Murphey, S.A., Risk factors for surgical site infection in the patient with spinal injury. Spine 28, 1475-1480, 2003.
164. Theiss, S.M., Lonstein, J.E., and Winter, R.B., Wound infections in reconstructive spine surgery. Orthop. Clin. North Am. 27, 105-110, 1996.
165. Levi, A.D., Dickman, C.A., and Sonntag, V.K., Management of postoperative infections after spinal instrumentation. J. Neurosurg. 86, 975-980, 1997.
166. Stambough, J.L., and Beringer, D., Postoperative wound infections complicating adult spine surgery. J. Spinal Disord. 5, 277-285, 1992.
167. Heggeness, M.H., Esses, S.I., Errico, T., and Yuan, H.A., Late infection of spinal instrumentation by hematogenous seeding. Spine 18, 492-496, 1993.
168. Richards, B.R., and Emara, K.M., Delayed infections after posterior TSRH spinal instrumentation for idiopathic scoliosis: revisited. Spine 26, 1990-1996, 2001.
169. Clark, C.E., and Shufflebarger, H.L., Late-developing infection in instrumented idiopathic scoliosis. Spine 24, 1909-1912, 1999.
170. Dubousset. J.S.H., and Wenger, D., Late “infection” with Cotrel-Dubousset instrumentation. Orthop. Trans. 18, 121, 1994.
171. Aydinli, U., Karaeminogullari, O., and Tiskaya, K., Postoperative deep wound infection in instrumented spinal surgery. Acta. Orthop. Belg. 65, 182-187, 1999.
172. Massie, J.B., Heller, J.G., Abitbol, J.J., McPherson, D., and Garfin, S.R., Postoperative posterior spinal wound infections. Clin. Orthop. 99-108, 1992.
173. Weinstein, M.A., McCabe, J.P., and Cammisa, Jr. F.P., Postoperative spinal wound infection: a review of 2, 391 consecutive index procedures. J. Spinal Disord. 13, 422-426, 2000.
174. Sponseller, P.D., LaPorte, D.M., Hungerford, M.W., Eck, K., Bridwell, K.H., and Lenke, L.G., Deep wound infections after neuromuscular scoliosis surgery: a multicenter study of risk factors and treatment outcomes. Spine 25, 2461-2466, 2000.
175. Perry, J.W., Montgomerie, J.Z., Swank, S., Gilmore, D.S., and Maeder, K., Wound infections following spinal fusion with posterior segmental spinal instrumentation. Clin. Infect. Dis. 24, 558-561, 1997.
176. Klekamp, J., Spengler, D.M., McNamara, M.J., and Haas, D.W., Risk factors associated with methicillin-resistant staphylococcal wound infection after spinal surgery. J. Spinal Disord. 12, 187-191, 1999.
177. Thalgott, J.S., Cotler, H.B., Sasso, R.C., LaRocca, H., and Gardner, V., Postoperative infections in spinal implants. Classification and analysis-a multicenter study. Spine 16, 981-984, 1991.
178. Wimmer, C., and Gluch, H., Management of postoperative wound infection in posterior spinal fusion with instrumentation. J. Spinal Disord. 9, 505-508, 1996.
179. Dernbach, P.D., Gomez, H., and Hahn, J., Primary closure of infected spinal wounds. Neurosurgery 26, 707-709, 1990.
180. Picada, R., Winter, R.B., Lonstein, J.E., et al., Postoperative deep wound infection in adults after posterior lumbosacral spine fusion with instrumentation: incidence and management. J. Spinal Disord. 13, 42-45, 2000.
181. Glassman, S.D., Dimar, J.R., Puno, R.M., and Johnson, J.R., Salvage of instrumental lumbar fusions complicated by surgical wound infection. Spine 21, 2163-2169, 1996.
182. Dietze, D.D., Jr., and Haid, R.W., Jr., Antibiotic-impregnated methylmethacrylate in treatment of infections with spinal instrumentation. Case report and technical note. Spine 17, 981-987, 1992.
183. Harle, A., and van Ende, R., Management of wound sepsis after spinal fusion surgery. Acta. Orthop. Belg. 57 Suppl 1, 242-246, 1991.
184. Abbey, D.M., Turner, D.M., Warson, J.S., Wirt, T.C., and Scalley, R.D., Treatment of postoperative wound infections following spinal fusion with instrumentation. J. Spinal Disord. 8, 278-283, 1995.
185. Soultanis, K., Mantelos, G., Pagiatakis, A., and Soucacos, P.N., Late infection in patients with scoliosis treated with spinal instrumentation. Clin. Orthop. 116-123, 2003.
186. Viola, R.W., King, H.A., Adler, S.M., and Wilson, C.B., Delayed infection after elective spinal instrumentation and fusion. A retrospective analysis of eight cases. Spine 22, 2444-2450. Discussion, 2450-2441, 1997.