Homologous and heterologous recombination between adenovirus vector DNA and chromosomal DNA

Journal of Gene Medicine

Volumn 10, Issue 11, 2008, Pages 1176-1189

  Stephen, Sam Laurel ^a   Sivanandam, Vijayshankar Ganesh ^a   Kochanek, Stefan ^a,b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Adenovirus vector; Genotoxicity; Integration; Recombination

Indexed keywords

ADENOVIRUS VECTOR; CELL DNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; VIRUS DNA; DNA; GLYCOSYLTRANSFERASE; HYPOXANTHINE GUANINE XANTHINE PHOSPHORIBOSYLTRANSFERASE; HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CONTROLLED STUDY; DNA INTEGRATION; DNA RECOMBINATION; DNA SEQUENCE; GENE DELETION; GENE INSERTION; GENE LOCUS; GENE MUTATION; GENE TRANSFER; HETEROLOGOUS RECOMBINATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; HUMAN CHROMOSOME; IN VITRO GENE TRANSFER; MALE; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROTO ONCOGENE; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING; TUMOR SUPPRESSOR GENE; ADENOVIRUS; BIOLOGICAL MODEL; CELL CULTURE; CHEMISTRY; CHROMOSOME; GENE VECTOR; GENETIC RECOMBINATION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

ADENOVIRIDAE;

ADENOVIRIDAE; BASE SEQUENCE; CELLS, CULTURED; CHROMOSOMES; DNA; DNA, VIRAL; GENETIC VECTORS; HUMANS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PENTOSYLTRANSFERASES; RECOMBINATION, GENETIC;

EID: 58149198186     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1246     Document Type: Article

References (34)

1. Hacein-Bey-Abina S, Von Kalle C, Schmidt M, et al. LMO2- associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 2003; 302: 415-419.
2. Hacein-Bey-Abina S, von Kalle C, Schmidt M, et al. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 2003; 348: 255-256.
3. Schulz M. Doerfler W Deletion of cellular DNA at site of viral DNA insertion in the adenovirus type 12-induced mouse tumor CBA-12-1-T. Nucleic Acids Res 1984; 12: 4959-4976.
4. Doerfler W, Gahlmann R, Stable S, et al. On the mechanism of recombination between adenoviral and cellular DNAs: the structure of junction sites. Curr Top Microbiol Immunol 1984; 109: 193-228.
5. Stabel S, Doerfler W, Friis RR. Integration sites of adenovirus type 12 DNA in transformed hamster cells and hamster tumor cells. J Virol 1980; 36: 22-40.
6. Mitani K, Kubo S. Adenovirus as an integrating vector. Curr Gene Ther 2002; 2: 135-144.
7. Fujita A, Sakagami K, Kanegae Y, et al. Gene targeting with a replication-defective adenovirus vector. J Virol 1995; 69: 6180-6190.
8. Wang Q, Taylor MW. Correction of a deletion mutant by gene targeting with an adenovirus vector. Mol Cell Biol 1993; 13: 918-927.
9. Overturf K, al-Dhalimy M, Ou CN, et al. Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I. Hum Gene Ther 1997; 8: 513-521.
10. Tsukui T, Kanegae Y, Saito I, et al. Transgenesis by adenovirusmediated gene transfer into mouse zona-free eggs. Nat Biotechnol 1996; 14: 982-985.
11. Wang H, Lieber A. A helper-dependent capsid-modified adenovirus vector expressing adeno-associated virus rep78 mediates site-specific integration of a 27-kilobase transgene cassette. J Virol 2006; 80: 11699-11709.
12. Wang H, Shayakhmetov DM, Leege T, et al. A capsid-modified helper-dependent adenovirus vector containing the beta-globin locus control region displays a nonrandom integration pattern and allows stable, erythroid-specific gene expression. J Virol 2005; 79: 10999-11013.
13. Ohbayashi F, Balamotis MA, Kishimoto A, et al. Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors. Proc Natl Acad Sci U S A 2005; 102: 13628-13633.
14. Hillgenberg M, Tonnies H, Strauss M. Chromosomal integration pattern of a helper-dependent minimal adenovirus vector with a selectable marker inserted into a 27.4-kilobase genomic stuffer. J Virol 2001; 75: 9896-9908.
15. Harui A, Suzuki S, Kochanek S, et al. Frequency and stability of chromosomal integration of adenovirus vectors. J Virol 1999; 73: 6141-6146.
16. Mitani K, Wakamiya M, Hasty P, et al. Gene targeting in mouse embryonic stem cells with an adenoviral vector. Somat Cell Mol Genet 1995; 21: 221-231.
17. Stout JT, Caskey CT. HPRT: gene structure, expression, and mutation. Annu Rev Genet 1985; 19: 127-148.
18. Nyhan WL. Disorders of purine and pyrimidine metabolism. Mol Genet Metab 2005; 86: 25-33.
19. Davidson BL, Tarle SA, Palella TD, et al. Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in ten subjects determined by direct sequencing of amplified transcripts. J Clin Invest 1989; 84: 342-346.
20. Kreppel F, Biermann V, Kochanek S, et al. A DNA-basedmethod to assay total and infectious particle contents and helper virus contamination in high-capacity adenoviral vector preparations. Hum Gene Ther 2002; 13: 1151-1156.
21. Wronka G, Fechteler K, Schmitz B, et al. Integrative recombination between adenovirus type 12 DNA and mammalian DNA in a cell-free system: joining by short sequence homologies. Virus Res 2002; 90: 225-242.
22. Hoglund M, Siden T, Rohme D Different pathways for chromosomal integration of transfected circular pSVneo plasmids in normal and established rodent cells. Gene 1992; 116: 215-222.
23. Takata M, Sasaki MS, Sonada E, et al. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J 1998; 17: 5497-5508.
24. Russell DW, Hirata RK Human gene targeting by viral vectors. Nat Genet 1998; 18: 325-330.
25. Lin FL, Sperle K, Sternberg N. Recombination in mouse L cells between DNA introduced into cells and homologous chromosomal sequences. Proc Natl Acad Sci USA 1985; 82: 1391-1395.
26. Doetschman T, Gregg RG, Maeda N, et al. Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature 1987; 330: 576-578.
27. Thomas K, Folger R, Capecchi MR High frequency targeting of genes to specific sites in the mammalian genome. Cell 1986; 44: 419-428.
28. Thomas KR, Capecchi MR Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 1987; 51: 503-512.
29. Bushman F, Lewinski M, Ciuffi A, et al. Genome-wide analysis of retroviral DNA integration. Nat Rev Microbiol 2005; 3: 848-858.
30. Miller DG, Trobridge GD, Petek LM, et al. Large-scale analysis of adeno-associated virus vector integration sites in normal human cells. J Virol 2005; 79: 11434-11442.
31. Yant SR, Wu X, Huang Y, et al. High-resolution genome-wide mapping of transposon integration in mammals. Mol Cell Biol 2005; 25: 2085-2094.
32. Sova P, Wang H, Bomsztyk K, et al. Role of Chromatin Structure in Integration of Helper-Dependent Adenoviral Vectors Containing the beta-Globin Locus Control Region. Hum Gene Ther 2008; 19: 153-166.
33. Fechteler K, Tatzelt J, Huppertz S, et al. The mechanism of adenovirus DNA integration: studies in a cell-free system. Curr Top Microbiol Immunol 1995; 199(Pt 2): 109-137.
34. Knoblauch M, Schrorer J, Schmitz B, et al. The structure of adenovirus type 12 DNA integration sites in the hamster cell genome. J Virol 1996; 70: 3788-3796.