Application of human CFU-Mk assay to predict potential thrombocytotoxicity of drugs

Toxicology in Vitro

Volumn 23, Issue 1, 2009, Pages 194-200

  Pessina, A ^a   Parent Massin, D ^b   Albella, B ^c   Heuvel, R Van Den ^d   Casati, S ^e   Croera, C ^e   Malerba, I ^e   Sibiril, Y ^b   Gomez, S ^c   de Smedt, A ^d   Gribaldo, L ^e  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

^c CIEMAT   (Spain)

^d FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

^e JOINT RESEARCH CENTRE   (Italy)

Author keywords

Alternative method; Haematotoxicity; Mk CFU assay; Thrombocytotoxicity

Indexed keywords

ALLOPURINOL; BUSULFAN; CARBAMAZEPINE; CARMUSTINE; CIMETIDINE; FLUOROURACIL; PENICILLAMINE; T 2 TOXIN; VALPROIC ACID; WARFARIN;

ARTICLE; BIOASSAY; CELL ASSAY; CELL GROWTH; COLONY FORMING UNIT; COLONY FORMING UNIT MEGAKARYOCYTE ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EXPOSURE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MEGAKARYOCYTE; REPRODUCIBILITY; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOCYTOTOXICITY;

ANIMAL TESTING ALTERNATIVES; BLOOD PLATELETS; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; FETAL BLOOD; HUMANS; MEGAKARYOCYTES; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; THROMBOCYTOPENIA;

EID: 58149191164     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.11.006     Document Type: Article

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