Changes in myelin basic protein and demyelination in the rat brain within 3 months of single 2-, 10-, or 30-Gy whole-brain radiation treatments: Laboratory investigation

Journal of Neurosurgery

Volumn 109, Issue 5, 2008, Pages 881-888

  Tian, Ye ^a   Shi, Zhige ^a   Yang, Shu ^a   Chen, Yingzhu ^a   Bao, Shiyao ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Demyelination; Myelin basic protein; Radiation injury; Whole brain radiation

Indexed keywords

FAST BLUE; MESSENGER RNA; MYELIN BASIC PROTEIN; MBP PROTEIN, RAT; NERVE PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN RADIATION; BRAIN TISSUE; CONTROLLED STUDY; DEMYELINATION; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; IRRADIATION; MALE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; ANIMAL; BRAIN; DEMYELINATING DISEASE; METABOLISM; METHODOLOGY; PATHOLOGY; RADIATION EXPOSURE; RADIATION RESPONSE; SKULL IRRADIATION; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; CRANIAL IRRADIATION; DEMYELINATING DISEASES; DOSE-RESPONSE RELATIONSHIP, RADIATION; MODELS, ANIMAL; NERVE TISSUE PROTEINS; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 58149173827     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/JNS/2008/109/11/0881     Document Type: Article

References (27)

1. Akiyama K, Tanaka R, Sato M, Takeda N: Cognitive dysfunction and histological findings in adult rats one year after whole brain irradiation. Neurol Med Chir (Tokyo) 41:590-598, 2001 (Pubitemid 34062383)
2. Altschuler E, Lunsford LD, Kondziolka D, Wu A, Maitz AH, Sclabassi R, et al: Radiobiologic models for radiosurgery. Neurosurg Clin N Am 3:61-77, 1992
3. Atkinson S, Li YQ, Wong CS: Changes in oligodendrocytes and myelin gene expression after radiation in the rodent spinal cord. Int J Radiat Oncol Biol Phys 57:1093-1100, 2003 (Pubitemid 37324128)
4. Baumann N, Pham-Dinh D: Biology of oligodendrocyte and myelin in the mammalian cental nervous system. Physiol Rev 81:871-927, 2001 (Pubitemid 32267079)
5. Belka C, Budach W, Kortmann RD, Bamberg M: Radiation induced CNS toxicity - molecular and cellular mechanisms. Br J Cancer 85:1233-1239, 2001 (Pubitemid 33081913)
6. Brown WR, Thore CR, Moody DM, Robbins ME, Wheeler K: Vascular damage after fractionated whole-brain irradiation in rats. Radiat Res 164:662-668, 2005
7. Chen J, Wang R, Li C, Xiong C, Wang D, Lin J, et al: [Simplified enzyme-linked immunoadsorbent assay for myelin basic protein and antibodies to myelin basic protein.] Hua Xi Yi Ke Da Xue Xue Bao 26:125-130, 1995 (Chinese)
8. Chiang CS, Mason KA, Withers HR, McBride WM: Alteration in Myelin-associated proteins following spinal cord irradiation in guinea pigs. Int J Radiat Oncol Biol Phys 24:929-937, 1992
9. Chiang CS, McBride WM, Withers HR: Myelin-associated changes in mouse brain following irradiation. Radiother Oncol 27:229-236, 1993
10. Cicciarello R, d'Avella D, Gagliardi ME, Albiero F, Vega J, Angileri FF, et al: Time-related ultrastructural changes in an experimental model of whole-brain radiation. Neurosurgery 38:772-780, 1996
11. Daigle JL, Hong JH, Chiang CS, McBride WM: The role of tumor necrosis factor signaling pathways in the response of murine brain to irradiation. Cancer Res 61:8859-8865, 2001
12. Fajardo LF, Berthrong M, Anderson RE: Radiation Pathology. New York: Oxford University Press, 2001, pp 351-361
13. Harauz G, Ishiyama N, Hill CM, Bates IR, Libich DS, Farès C: Myelin basic protein-diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis. Micron 35:503-542, 2004 (Pubitemid 38836830)
14. Joiner MC, Bentzen SM: Time-dose relationships: the linear-quadratic approach, in Steel GG (ed): Basic Clinical Radiobiology. London: Edward Arnold Ltd, 2002, pp 105-133
15. Liu Y, Silverstein FS, Skoff R, Barks JD: Hypoxic-ischemic oliogodenglial injury in neonatal rat brain. Pediatr Res 51:25-33, 2002 (Pubitemid 34008206)
16. Lunsford LD, Altschuler EM, Flickinger JC, Wu A, Martinez AJ: In vivo biological effects of stereotactic radiosurgery: a primate model. Neurosurgery 27:373-382, 1990 (Pubitemid 20294092)
17. Lyubimova N, Hopewell JW: Experimental evidence to support the hypothesis that damage to vascular endothelium plays the primary role in the development of late radiation-induced CNS injury. Br J Radiol 77:488-492, 2004 (Pubitemid 38807563)
18. Monje ML, Mizumatsu S, Fike JR, Palmer TD: Irradiation induces neural precursor-cell dysfunction. Nat Med 8:955-961, 2002
19. Ohta M, Ohta K, Ma J, Takeuchi J, Saida T, Nishimura M, et al: Clinical and analytical evaluation of an enzyme immunoassay for myelin basic protein in cerebrospinal fluid. Clin Chem 46:1326-1330, 2000
20. Paxinos G, Watson C: The Rat Brain in Stereotactic Coordinates, ed 2. New York: Academic Press, 1986, pp 86-93
21. Reinhold HS, Calvo W, Hopewell JW, van den Berg AP: Development of blood vessel-related radiation damage in the fimbria of the central nervous system. Int J Radiat Oncol Biol Phys 18:37-42, 1990 (Pubitemid 20047388)
22. Sato G, Tanaka R, Akiyama K, Yamanaka R, Sato M: Immunohistochemical analysis of myelination following hemicranial irradiation in neonatal rats. Neurosci Lett 353:131-134, 2003 (Pubitemid 37510198)
23. Schultheiss TE, Kun LE, Ang KK, Stephens LC: Radiation response of the central nervous system. Int J Radiat Oncol Biol Phys 31:1093-1112, 1995
24. Skoff RP, Bessert DA, Barks JDE, Song D, Cerghet M, Silverstein FS: Hypoxic-ischemic injury results in acute disruption of myelin gene expression and death of oliogodenglial precursors in neonatal mice. Int J Dev Neurosci 19:197-208, 2001 (Pubitemid 32194655)
25. Tofilon PJ, Fike JR: The radioresponse of the central nervous system: a dynamic process. Radiat Res 153:357-370, 2000
26. van der Kogel AJ: Central nervous system injury in small animal models, in Gutin PH, Leibel SA, Sheline GE (eds): Radiation Injury to the Nervous System. New York: Raven Press, 1991, pp 91-111
27. Yoneoka Y, Satoh M, Akiyama K, Sano K, Fujii Y, Tanaka R: An experimental study of radiation-induced cognitive dysfunction in an adult rat model. Br J Radiol 72:1196-1201, 1999 (Pubitemid 30028933)