Radiomodulatory and free-radical scavenging activity of the fractionated aquo-alcoholic extract of the adaptogenic nutraceutical (Rhodiola imbricata) - A comparative in vitro assessment with ascorbate

Journal of Dietary Supplements

Volumn 5, Issue 2, 2008, Pages 147-163

  Arora, Rajesh ^a   Singh, Shikha ^a   Sagar, R K ^a   Chawla, Raman ^a   Kumar, R ^a   Puri, S C ^b   Surender, S ^a   Prasad, J ^a   Gupta, M L ^a   Krishna, B ^d   Siddiqui, M S ^e   Sharma, A K ^a   Tripathi, R P ^a   Qazi, G N ^b   Sharma, Rakesh Kumar ^b,c  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^c Defence R D Organization   (India)

^d MAULANA AZAD MEDICAL COLLEGE   (India)

^e HAMDARD UNIVERSITY   (India)

Author keywords

Free radical; Radiation damage; Radio protection; Rhodiola imbricata

Indexed keywords

ASCORBIC ACID; FREE RADICAL; HEMATOLOGIC AGENT; PLANT EXTRACT; RADIOPROTECTIVE AGENT; SCAVENGER;

ARTICLE; BLOOD; CELL MEMBRANE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; ERYTHROCYTE; HUMAN; IONIZING RADIATION; METABOLISM; PHYTOTHERAPY; RADIATION EXPOSURE; RADIATION INJURY; RHODIOLA;

ASCORBIC ACID; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; FREE RADICAL SCAVENGERS; FREE RADICALS; HEMATOLOGIC AGENTS; HUMANS; PHYTOTHERAPY; PLANT EXTRACTS; RADIATION INJURIES; RADIATION, IONIZING; RADIATION-PROTECTIVE AGENTS; RHODIOLA;

RHODIOLA;

EID: 58149173793     PISSN: 19390211     EISSN: None     Source Type: Journal    
DOI: 10.1080/19390210802332695     Document Type: Article

References (40)

1. Arora, R., Chawla, R., Prasad, J., Singh, S., Kumar, R., Sharma, A., et al. (2005a). Radioprotective activity of Rhodiola imbricata - a high altitude medicinal plant. Molecular Cellular Biochemistry, 273, 209-223.
2. Arora, R., Chawla, R., Puri, S.C., Sagar, R.K., Singh, S., Kumar, R., et al. (2005b). Radioprotective activity of low altitude Podophyllum hexandrum. Journal of Environmental Pathology, Toxicology and Oncology, 24, 253-269.
3. Arora, R., Gupta, D., Chawla, R., Prasad, J., Singh, S., Sharma, A.K., et al., (2005c). Radioprotection by plant products: Present status and future prospects. Phytotherapy Research, 19, 1-22.
4. Baudouin, C., Charveron, M., Tarroux, R. & Gall, Y. (2002). Environmental pollutants and skin cancer. Cell Biology and Toxicology, 18, 341-348.
5. Bol'shakova, I.V., Lozovskaia, E.L. & Sapezhinskii, I.I. (1998). Antioxidant properties of series of extracts from medicinal plants. Biofizika, 43, 186-188.
6. Brizel, D.M. & Overgaard, J., (2003). Does amifostine have a role in chemoradiation treatment? The Lancet Oncology, 4, 378-381.
7. Brown, R.P., Gerbarg, P.L. & Ramazanov. (2002). Z. Rhodiola rosea: A phytomedicinal overview. Herbal Gram, 56, 40-52.
8. Celendon, C., Gonzalez, C., Lissi, E.A. & Hidalgo, G. (2001). Free radical induced protein degradation of erythrocyte membrane is induced by localization of free radical generation. IUBMB Life, 51, 377-380.
9. Chaurasia, O.P. & Singh, B. (1996). Cold Desert Plants. Vol. 1, DRDO, Leh, India: Leh Valley, Field Research Lab. (FRL).
10. Chawla, R., Arora, R., Kumar, R., Sharma, A.K., Prasad, J., Singh, S., et al., (2005a). Antioxidant activities of fractionated extracts of High Altitude Podophyllum hexandrum in radiation protection. Molecular Cellular Biochemistry, 273, 193-208.
11. Chawla, R., Arora, R., Sagar, R.K., Singh, S., Puri, S.C., Kumar, R., et al. (2005b). 3-O-β-D- galactopyranoside of quercetin as an active principle from high-altitude Podophyllum hexandrum and evaluation of its radioprotective properties. Zeitschrift für Naturforschung, 60, 728-738.
12. Colson, S.N., Wyatt, F.B., Jonhston, D.L., Autrey, L.D., Fitzgerald, Y.L. & Earnest, C.P. (2005). Cordyceps sinensis- and Rhodiola rosea-bused supplementation in male cyclists and its effect on muscle tissue oxygen saturation. Journal of Strength and Conditioning, 19, 358-363.
13. Dacie, J.V. & Lewis, S.M. (1995). Practical Hematology (8th Ed.). Edinburgh, U.K.: Churchill Livingstone.
14. Darbinyan, V., Kteyan, A. & Panossian, A. (2000). Rhodiola rosea in stress-induced fatigue a double blind cross-over study of a standardized extract SHR-5 with a repeated low dose regimen on the mental performance of healthy physicians on night duty. Phytomedicine, 7, 365-371.
15. De Sanctis, R., De Bellis, R., Scesa, C., Mancini, U., Cucchiarini, L. & Dacha, M. (2004). In vitro protective effect of Rhodiola rosea extract against hypochlorous acid-induced oxidative damage in human erythrocytes. Biofactors, 20, 147-159.
16. Germano, C., Ramazanov, Z. & Bernai, S.M. (1999). Arctic root (Rhodiola rosea): The powerful new Ginseng alternative. New York: Kensington Publishing Corporation.
17. Goel, H.C., Kumar, I.P., Samanta. N. & Rana, S.V.S. (2003). Induction of DNA-protein cross-links by Hippophae rhamnoides, implications in radioprotection and cytotoxicity. Molecular and Cellular Biochemistry, 245, 57-67.
18. Grant, III, W., Cundiff, J., Hanson, W., Gagnon, W. & Shalek, R. (1976). Calibration instrumentation used by the AAPM radiological physics center. Medical Physics, 3, 353-354.
19. Green, L.C., Wagner, D.A. & Glogowski, J. (1982). Analysis of nitrate, nitrite and nitrate in biological fluids. Analytical Biochemistry, 126, 131-138.
20. Gupta, D., Arora, R., Garg, A.P. & Goel, H.C. (2003). Radiation-induced damage to mitochondria and its modification by Podophyllum hexandrum Royale in HepG2 cells. Molecular and Cellular Biochemistry, 247, 25-40.
21. Iaremii, I.N. & Grigor'eva, N.F. (2002). Hepatoprotective properties of liquid extract of Rhodiola rosea. Eksperimental'naia i Klinicheskaia Farmakologiia, 65, 57-59.
22. Kakkar, P., Das, B. & Viswanathan, P.N. (1984). A modified spectrophometric assay of superoxide dismutase. Indian Journal of Biochemisry & Biophysics, 21, 110-133.
23. Kanupriya, D., Prasad, D., Sairam, M., Kumar, R., Sawhney, R.C., Sharma, S.K., et al., (2005). Cytoprotective and antioxidant activity of Rhodiola imbricata against tertbutyl hydroperoxide injury in U-937 human macrophages. Molecular and Cellular Biochemistry, 275, 1-6.
24. Kelly, G.S. (2001). Rhodiola rosea: A possible plant adaptogen. Alternative Medical Reviews, 6, 293-302.
25. Kitts, D.D., Wijewickreme, A.N. & Hu, C. (2000). Antioxidant properties of a North American ginseng extract. Molecular and Cellular Biochemistry, 203, 1-10.
26. Komar, V.B., Kit, S.M., Sischuk, L.V. & Sischuk, V.M. (1981). Effect of Rhodiola rosea on the human mental activity. Pharmaceutical Journal, 36, 62-64.
27. Konopacka, M. (1996). Vitamins as radioprotectors of normal cells. Postepy Higieny i Medycyny Doswiadczalnej, 50, 145-156.
28. Li, J., Fan, W.H. & Ao, H. (2005). Effect of Rhodiola on expressions of FIt-1, KDR and Tie-2 in rats with ischemic myocardium. Zhongguo Zhong Xi Ti Jie He Za Zhi, 25, 445-448.
29. Maimeskulova, L.A. & Maslov, L.N. (1998). The anti-arrhythimia action of an extract of Rhodiola rosea and of n-tyrosol in models of experimental arrhythmias. Eksperimental'naia i Klinicheskaia Farmakologiia, 61, 37-40.
30. Maisin, J.R. (1998). Chemical radioprotection: Past, present and future prospects. International Journal of Radiation Biology, 73, 443-450.
31. Maslova, L.V., Kondratev, B.I., Maslov, L.N. & Lishmanov, I.B. (1994). The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress. Eksperimental'naia i Klinicheskaia Farmakologiia, 57, 61-63.
32. Nair, C.K.K., Parida, D.K. & Nomura, T (2001). Radioprotectors in Radiotherapy. Journal of Radiation Research, 42, 21-37.
33. Ohwi, J. (1984). Flora of Japan (p. 495). Washington, DC: Smithsonian Institution.
34. Oyaizu, M. (1986). Antioxidative activity of browning products of glucosamine fractionated by organic solvent and thin layer chromatography. Nippon ShoKuhin Kogvo Gakkaishi, 35, 771-775.
35. Provalova, N. V., Skurikhin, E.G., Pershina, O.V., Suslov, N.I., Minakova, M.Y., Dygai, A.M., et al., (2002). Mechanisms underlining the effects of adaptogens on erythropoiesis during paradoxical sleep deprivation. Bulletin of Experimental Biology and Medicine, 133, 428-432.
36. Ramazanov, Z. & Maria del, M.B.S. (1999). New secrets of effective natural stress and weight management using Rhodiola rosea and Rhododendron caucasicum (pp. 88). East Cannan, CT: ATN/Safe Goods Publishing.
37. Sagar, R.K., Chawla, R., Arora, R., Singh, S., Krishna, B., Sharma, R.K., et al., (2006). Protection of hematopoietic system by Podophyllum hexandrum. Planta Medica, 72, 114-120.
38. Scholes, G. (1982). Radiation effects on DNA: The Silvanus Thomson memorial lecture April 1982. The British Journal of Radiology, 56, 221-231.
39. Spasov, A.A., Wikman, G.K., Mandrikov, V.B., Mironova, I.A. & Neumoin, V.V. (2000). A double-blind, placebo-control pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low dose regimen. Phytomedicine, 7, 85-89.
40. Sweeney, T.R. (1979). A survey of compounds from the anti-radiation drug development program of the US Army Medical Research and Development Command. Washington, DC: Government Printing Office.