The Janus effect: Two faces of aldosterone

Kidney International

Volumn 75, Issue 2, 2009, Pages 137-139

  Brem, Andrew S ^a,b  

^a BROWN UNIVERSITY   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ALDOSTERONE; ANGIOTENSIN 1 RECEPTOR; CORTISONE; DEHYDROCORTICOSTERONE; GLUCOCORTICOID; HYDROCORTISONE; MINERALOCORTICOID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SODIUM; SPIRONOLACTONE;

ALDOSTERONE BLOOD LEVEL; DRUG EFFECT; HUMAN; HYPERTENSION; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEINURIA; SODIUM TRANSPORT;

EID: 58149166822     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.567     Document Type: Note

References (18)

1. Ikeda H, Tsuruya K, Toyonaga J et al. Spironolactone suppresses inflammation and prevents l-NAME-induced renal injury in rats. Kidney Int 2009; 75: 147-155.
2. Kataoka H, Otsuka F, Ogura T et al. The role of nitric oxide and the renin-angiotensin system in salt-restricted Dahl rats. Am J Hypertens 2001; 14: 276-285.
3. Pechanova O, Matuskova J, Capikova D et al. Effect of spironolactone and captopril on nitric oxide and S-nitrosothiol formation in kidney of L-NAME-treated rats. Kidney Int 2006; 70: 170-176.
4. Nagase M, Shibata S, Yoshida S et al. Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension 2006; 47: 1084-1093.
5. Hanke CJ, Drewett JG, Myers CR et al. Nitric oxide inhibits aldosterone synthesis by a guanylyl cyclase-independent effect. Endocrinology 1998; 139: 4053-4060.
6. Kreklau EL, Carlson EJ, Drewett JG. Nitric oxide inhibits human aldosteronogenesis without guanylyl cyclase stimulation. Mol Cell Endocrinol 1999; 153: 103-111.
7. Nithipatikom K, Holmes BB, McCoy MJ et al. Chronic administration of nitric oxide reduces angiotensin II receptor type 1 expression and aldosterone synthesis in zona glomerulosa cells. Am J Physiol Endocrinol Metab 2004; 287: E820-E827.
8. Nithipatikom K, Holmes BB, Isbell MA et al. Measurement of steroid synthesis in zona glomerulosa cells by liquid chromatography-electro-spray ionization-mass spectrometry: inhibition by nitric oxide. Anal Biochem 2005; 337: 203-210.
9. Funder JW, Feldman D, Edelman IS. The roles of plasma binding and receptor specificity in the mineralocorticoid action of aldosterone. Endocrinology 1973; 92: 994-1004.
10. Barger AC, Berlin RD, Tulenko JF. Infusion of aldosterone, 9-alpha-fluorohydrocortisone, and antidiuretic hormone into the renal artery of normal and adrenalectomized unanesthetized dogs: effect on electrolyte and water excretion. Endocrinology 1958; 62: 804-815.
11. Uete T, Venning EH. The effect of cortisone, hydrocortisone, and 9-alpha-fluoro-16-alpha-hydroxy-delta-hydrocortisone on the action of desoxycorticosterone and aldosterone with respect to electrolyte excretion. Endocrinology 1960; 67: 62-69.
12. Alberti KGMM, Sharp GWG. I dentification of four types of steroid by their interaction with mineralocorticoid receptors in the toad bladder. J Endocrinology 1970; 48: 563-574.
13. Brem AS, Matheson KL, Barnes JL et al. 11-Dehydrocorticosterone, a glucocorticoid metabolite, inhibits aldosterone action in toad bladder. Am J Physiol 1991; 261: F873-F879.
14. Kenyon CJ, Saccoccio NA, Morris DJ. Glucocorticoid inhibition of mineralocorticoid action in the rat. Clin Sci (Lond) 1984; 67: 329-335.
15. Morris DJ, Souness GW, Brem AS et al. Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues. Kidney Int 2000; 57: 1370-1373.
16. Odermatt A, Arnold P, Frey FJ. The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2. J Biol Chem 2001; 276: 28484-28492.
17. Funder J. Mineralocorticoids and cardiac fibrosis: the decade in review. Clin Exp Pharmacol Physiol 2001; 28: 1002-1006.
18. Remuzzi G, Cattaneo D, Perico N. The aggravating mechanisms of aldosterone on kidney fibrosis. J Am Soc Nephrol 2008; 19: 1459-1 462.