Candidate genes and cerebral palsy: A population-based study

Pediatrics

Volumn 122, Issue 5, 2008, Pages 1079-1085

  Gibson, Catherine S ^a   MacLennan, Alastair H ^a   Dekker, Gustaaf A ^a   Goldwater, Paul N ^a,b   Sullivan, Thomas R ^c   Munroe, David J ^d   Tsang, Shirley ^d   Stewart, Claudia ^d   Nelson, Karin B ^e,f,g  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d SAIC FREDERICK INC   (United States)

^e NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^f CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^g NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cerebral palsy; Genetics; IL 8; Nitric Oxide synthase; Prematurity

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; ENDOTHELIAL PROTEIN C RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 8; LYMPHOTOXIN; 5-LIPOXYGENASE-ACTIVATING PROTEIN; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; CARRIER PROTEIN; CELL SURFACE RECEPTOR; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROCR PROTEIN, HUMAN; PROTEIN C; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; AUSTRALIA; CASE CONTROL STUDY; CEREBRAL PALSY; CONTROLLED STUDY; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; GESTATIONAL AGE; HEMIPLEGIA; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; POPULATION RESEARCH; PREMATURITY; PRIORITY JOURNAL; QUADRIPLEGIA; SINGLE NUCLEOTIDE POLYMORPHISM; EPIDEMIOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; NEWBORN; NEWBORN SCREENING; PHYSIOLOGY; RISK ASSESSMENT;

ANTIGENS, CD; CARRIER PROTEINS; CASE-CONTROL STUDIES; CEREBRAL PALSY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INTERLEUKIN-8; MALE; MEMBRANE PROTEINS; NEONATAL SCREENING; NITRIC OXIDE SYNTHASE TYPE II; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN C; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, CELL SURFACE; RISK ASSESSMENT; SEROEPIDEMIOLOGIC STUDIES; SOUTH AUSTRALIA;

EID: 58149166310     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2007-3758     Document Type: Article

References (37)

1. Little WJ. On the influence of abnormal parturition, difficult labour, premature birth, and asphyxia neonatorum on the mental and physical condition of the child, especially in relation to deformities. Tr Obst Soc London 1861;3:293
2. Wu YW, March WM, Croen LA, Grether JK, Escobar GJ, Newman TB. Perinatal stroke in children with motor impairment: a population-based study. Pediatrics. 2004;114(3):612-619
3. Raju T, Nelson KB, Ferriero D, Lynch JK, NICHD-NINDS Perinatal Stroke Workshop Participants. Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National institute of Neurological Disorders and Stroke. Pediatrics. 2007; 120(3):609-616
4. Gibson CS, MacLennan AH, Goldwater PN, et al. The association between inherited cytokine polymorphisms and cerebral palsy. Am J Obstet Gynecol. 2006;194(3):674.e1-674.e11
5. Nelson KB, Dambrosia JM, Iovannisci DM, Cheng S, Grether JK, Lammer E. Genetic polymorphisms and cerebral palsy in very preterm infants. Pediatr Res. 2005;57(4):494-499
6. Meirelles Kalil Pessao de Barr, Rodrigues CJ, de Baros TE, Bevilacqua RG. Presence of apolipoprotein E epsilon4 allele in cerebral palsy. J Pediatr Orthop. 2000;20(6):786-789
7. Kuroda MM, Weck ME, Sarwark JF, Hamidullah A, Wain- wright MS. Association of apolipoprotein E genotype and cerebral palsy in children. Pediatrics. 2007;119(2):306-313
8. Bundey S, Griffiths MI. Recurrence risks in families of children with symmetrical spasticity. Dev Med Child Neurol. 1977;19(2): 179-191
9. Hemminki K, Sundquist K, Li X. Familial risks for main neurological diseases in siblings based on hospitalizations in Sweden. Twin Res Hum Genet. 2006;9(4):580-586
10. Gibson CS, MacLennan AH, Hague WM, et al. Associations between inherited thrombophilias, gestational age, and cerebral palsy. Am J Obstet Gynecol. 2005;193(4):1437
11. Johnston MV, Hagberg H. Sex and the pathogenesis of cerebral palsy. Dev Med Child Neurol. 2007;49(1):74-78
12. Ballerio R, Gianazza E, Mussoni L, et al. Gender differences in endothelial function and inflammatory markers along the occurrence of pathological events in stroke-prone rats. Exp Mol Pathol. 2007;82(1):33-41
13. Khoury MJ, Little J. Human genome epidemiologic reviews: the beginning of something HuGE. Am J Epidemiol. 2000; 151(1):2-3
14. Naseem KM. The role of nitric oxide in cardiovascular diseases. Mol Aspects Med. 2005;26(1-2):33-65
15. Duncan AJ, Heales SJ. Nitric oxide and neurological disorders. Mol Aspects Med. 2005;26(1-2):67-96
16. Boullerne AI, Benjamins JA. Nitric oxide synthase expression and nitric oxide toxicity in oligodendrocytes. Antioxid Redox Signal. 2006;8(5-6):967-980
17. Shen Y, Yu HM, Yuan TM, Gu WZ, Wu YD. Intrauterine infection induced oligodendrocyte injury and inducible nitric oxide synthase expression in the developing rat brain. J Perinat Med. 2007;35(3):203-209
18. Kadhim H, Khalifa M, Deltenre P, Casimir G, Sebire G. Molecular mechanisms of cell death in periventricular leukomalacia. Neurology. 2006;67(2):293-299
19. Forster C, Clark HB, Ross ME, Iadecola C. Inducible nitric oxide synthase expression in human cerebral infarcts. Acta Neuro- pathol (Berl). 1999;97(3):215-220
20. Ozaki K, Ohnishi Y, Iida A, et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet. 2002;32(4):650-654
21. Szolnoki Z, Havasi V, Talian G, et al. Lymphotoxin-alpha gene 252G allelic variant is a risk factor for large-vessel-associated ischemic stroke. J Mol Neurosci. 2005;27(2):205-211
22. Asselbergs FW, Pai JK, Rexrode KM, Hunter DJ, Rimm EB. Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease. Clin Sci (Lond). 2007;112(5):291-298
23. Yesilirmak DC, Kumral A, Baskin H, et al. Activated protein C reduces endotoxin-induced white matter injury in the developing rat brain. Brain Res. 2007;1164:14-23
24. Genc K. The rationale for activated protein C treatment in perinatal white matter injury. Med Hypotheses. 2007;68(6):1418 -1419
25. Nelson PG, Kuddo T, Song EY, et al. Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. Int J Dev Neurosci. 2006;24(1):73-80
26. Ellison VJ, Mocatta TJ, Winterbourn CC, Darlow BA, Volpe JJ, InderTE. The relationship of CSF and plasma cytokine levels to cerebral white matter injury in the premature newborn. Pediatr Res. 2005;57(2):282-286
27. Nelson K, Dambrosia JM, Grether JK, Phillips TM. Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol. 1998;44(4):665-675
28. Yoon BH, Park CW, Chaiworapongsa T. Intrauterine infection and the development of cerebral palsy. BJOG. 2003;110(suppl 20):124-127
29. Cartier L, Hartley O, Dubois-Dauphin M, Krause KH. Chemo- kine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev. 2005;48(1):16-42
30. Resch BE, Ducza E, Gaspar R, Falkay G. Role of adrenergic receptor subtypes in the control of human placental blood vessels. Mol Reprod Dev. 2003;66(2):166-171
31. Loza MJ, Peters SP, Foster S, Khan IU, Penn RB. Beta-agonist enhances type 2 T-cell survival and accumulation. J Allergy Clin Immunol. 2007;119(1):235-244
32. Wessel J, Moratorio G, Rao F, et al. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007;25(2):329-343
33. Gibson CS, MacLennan AH, Dekker GA, et al. Genetic polymorphisms and spontaneous preterm birth. Obstet Gynecol. 2007;109(2 pt 1):384-391
34. Hoon AH Jr. Neuroimaging in cerebral palsy: patterns of brain dysgenesis and injury. J Child Neurol. 2005;20(12):936-939
35. Bax M, Tydeman C, Flodmark O. Clinical and MRI correlates of cerebral palsy: the European Cerebral Palsy Study. JAMA. 2006;296(13):1602-1608
36. Wu YW, Croen LA, Shah SJ, Newman TB, Naijar DV. Cerebral palsy in a term population: risk factors and neuroimaging findings. Pediatrics. 2006;118(2):690-697
37. Miller SP, Wu YW, Lee J, et al. Candidate gene polymorphisms do not differ between newborns with stroke and normal controls. Stroke. 2006;37(11):2678-2683