The rationale for activated protein C treatment in perinatal white matter injury

Medical Hypotheses

Volumn 68, Issue 6, 2007, Pages 1418-1419

  Genc, Kursad ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ENDOTHELIAL PROTEIN C RECEPTOR;

ADULT; ANTICOAGULATION; ANTIINFLAMMATORY ACTIVITY; BLEEDING; BLOOD CLOTTING; BRAIN INJURY; BRAIN PERIVENTRICULAR LEUKOMALACIA; ENDOTHELIUM CELL; EXPERIMENTAL MODEL; HUMAN; INFANT; INFLAMMATION; LETTER; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; PERINATAL WHITE MATTER INJURY; POSTNATAL CARE; PREGNANCY; PREMATURITY; PRENATAL CARE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RISK REDUCTION; WHITE MATTER;

ANTI-INFLAMMATORY AGENTS; ENZYME ACTIVATION; FEMALE; HUMANS; INFANT, NEWBORN; LEUKOMALACIA, PERIVENTRICULAR; MODELS, NEUROLOGICAL; PREGNANCY; PROTEIN KINASE C;

EID: 33947705801     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.11.021     Document Type: Letter

References (9)

1. Back S.A. Perinatal white matter injury: the changing spectrum of pathology and emerging insights into pathogenetic mechanisms. Ment Retard Dev Disabil Res Rev 12 (2006) 129-140
2. Balcaitis S., Xie Y., Weinstein J.R., Andersen H., Hanisch U.K., Ransom B.R., et al. Expression of proteinase-activated receptors in mouse microglial cells. Neuroreport 14 (2003) 2373-2377
3. Chan A.K., Patel S., Male C., Berry L.R., and Mitchell L.G. Activated protein C generation is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium. Thromb Haemost 91 (2004) 238-247
4. Esmon C.T. The endothelial protein C receptor. Curr Opin Hematol 13 (2006) 382-385
5. Griffin JH, Fernandez JA, Mosnier LO, Liu D, Cheng T, Guo H et al., The promise of protein C. Blood Cells Mol Dis 77 2006;36: p. 211-16.
6. Ishii S., Mochizuki T., Nagao T., Kudo S., Fujita A., Taniguchi K., et al. Pharmacokinetics of human activated protein C. 2nd communication: tissue distribution study of a lyophilized purified human activated protein C after single or repeated intravenous administration in male mice and placental transfer and milk passage study after intravenous administration in pregnant and lactating mice. Arzneimittelforschung 45 (1995) 644-656
7. Leviton A., and Dammann O. Coagulation, inflammation, and the risk of neonatal white matter damage. Pediatr Res 55 (2004) 541-545
8. Monnet X., Lamia B., Anguel N., Richard C., Bonmarchand G., and Teboul J.L. Rapid and beneficial hemodynamic effects of activated protein C in septic shock patients. Intensive Care Med 31 (2005) 1573-1576
9. Yamaji K., Wang Y., Liu Y., Abeyama K., Hashiguchi T., Uchimura T., et al. Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation. Thromb Res 115 (2005) 319-325