Intraosseous delivery of paclitaxel-loaded hydroxyapatite-alginate composite beads delaying paralysis caused by metastatic spine cancer in rats: Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 9, Issue 5, 2008, Pages 502-510

  Tetsuya, Abe ^a   Sakane, Masataka ^a   Ikoma, Toshiyuki ^b   Kobayashi, Mihoko ^c   Nakamura, Satoshi ^c   Ochiai, Naoyuki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NATIONAL INSTITUTE FOR MATERIALS SCIENCE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Hydroxyapatite alginate composite bead; Intraosseous chemotherapy; Metastatic spine cancer; Paclitaxel; Paralysis

Indexed keywords

ALGINIC ACID; HYDROXYAPATITE; PACLITAXEL; ANTINEOPLASTIC AGENT; DRUG CARRIER; GLUCURONIC ACID; HEXURONIC ACID; MICROSPHERE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CONTROL; COMPOSITE MATERIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE INTERVAL; DISEASE FREE SURVIVAL; DRUG DELIVERY SYSTEM; DRUG EFFECT; FEMALE; HISTOPATHOLOGY; LIMB; LOG RANK TEST; MORPHOMETRICS; MOTOR PERFORMANCE; NONHUMAN; PARALYSIS; QUALITY OF LIFE; RAT; RATING SCALE; SPINAL CORD COMPRESSION; SPINE METASTASIS; STATISTICAL SIGNIFICANCE; SURVIVAL TIME; ADENOCARCINOMA; ANIMAL; FISCHER 344 RAT; PATHOLOGY; SPINAL CORD TUMOR; SPRAGUE DAWLEY RAT;

ADENOCARCINOMA; ALGINATES; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DRUG CARRIERS; DURAPATITE; FEMALE; GLUCURONIC ACID; HEXURONIC ACIDS; MICROSPHERES; PACLITAXEL; PARALYSIS; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; SPINAL NEOPLASMS;

EID: 58149159285     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/SPI.2008.9.11.502     Document Type: Article

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