Embryonic stem cell rescue of tremor and ataxia in myelin-deficient shiverer mice

Journal of the Neurological Sciences

Volumn 276, Issue 1-2, 2009, Pages 133-137

  Low, Hoi Pang ^a   Gréco, Béatrice ^a   Tanahashi, Yusuke ^a   Gallant, Judith ^a   Jones, Stephen N ^a   Billings Gagliardi, Susan ^a   Recht, Lawrence D ^a   Schwartz, William J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Blastocyst injection; Chimera; Myelin basic protein; Oligodendrocytes; Shiverer mice; Stem cells; White matter; X gal histochemistry

Indexed keywords

MYELIN BASIC PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; ATAXIA; BLASTOCYST; BRAIN; EMBRYONIC STEM CELL; FEMALE; IMMUNOREACTIVITY; MALE; MOUSE; MYELIN DEFICIENCY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREMOR;

ANIMALS; ATAXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DEMYELINATING DISEASES; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; GENOTYPE; GLIAL FIBRILLARY ACIDIC PROTEIN; MICE; MICE, NEUROLOGIC MUTANTS; MUTATION; MYELIN BASIC PROTEINS; PHOSPHOPYRUVATE HYDRATASE; TREMOR;

EID: 58149147320     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2008.09.037     Document Type: Article

References (24)

1. Roach A., Takahashi N., Pravtcheva D., Ruddle F., and Hood L. Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice. Cell 42 (1985) 149-155
2. Chernoff G.F. Shiverer: an autosomal recessive mutant mouse with myelin deficiency. J Hered 72 (1981) 128
3. Readhead C., Popko B., Takahashi N., Shine H.D., Saavedra R.A., Sidman R.L., et al. Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Cell 48 (1987) 703-712
4. Mitome M., Low H.P., van den Pol A., Nunnari J.J., Wolf M.K., Billings-Gagliardi S., et al. Towards the reconstruction of central nervous system white matter using neural precursor cells. Brain 124 (2001) 2147-2161
5. Duncan I.D. Oligodendrocytes and stem cell transplantation: their potential in the treatment of leukoencephalopathies. J Inherit Metab Dis 28 (2005) 357-368
6. Keyoung H.M., and Goldman S.A. Glial progenitor-based repair of demyelinating neurological diseases. Neurosurg Clin N Am 18 (2007) 93-104
7. Radtke C., Spies M., Sasaki M., Vogt P.M., and Kocsis J.D. Demyelinating diseases and potential repair strategies. Int J Dev Neurosci 25 (2007) 149-153
8. Eftekharpour E., Karimi-Abdolrezaee S., Wang J., Beheiry H.E., Morshead C., and Fehlings M.G. Myelination of congenitally dysmyelinated spinal cord axons by adult neural precursor cells results in formation of nodes of Ranvier and improved axonal conduction. J Neurosci 27 (2007) 3416-3428
9. Izrael M., Zhang P., Kaufman R., Shinder V., Ella R., Amit M., et al. Human oligodendrocytes derived from embryonic stem cells: effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. Mol Cell Neurosci 34 (2007) 310-323
10. Yandava B.D., Billinghurst L.L., and Snyder E.Y. "Global" cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain. Proc Natl Acad Sci USA 96 (1999) 7029-7034
11. Kuhn P.L., Petroulakis E., Zazanis G.A., and McKinnon R.D. Motor function analysis of myelin mutant mice using a rotarod. Int J Dev Neurosci 13 (1995) 715-722
12. Windrem M.S., Schanz S.J., Guo M., Tian G.F., Washco V., Stanwood N., et al. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell 2 (2008) 553-565
13. Inoue Y., Mikoshiba K., Yokoyama M., Inoue K., Terashima T., Nomura T., et al. Alteration of the primary pattern of central myelin in a chimaeric environment - study of shiverer ↔ wild-type chimaeras. Dev Brain Res 26 (1986) 239-247
14. Guidi C.J., Sands A.T., Zambrowicz B.P., Turner T.K., Demers D.A., Webster W., et al. Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. Mol Cell Biol 21 (2001) 3598-3603
15. Gomez C.M., Muggleton-Harris A.L., Whittingham D.G., Hood L.E., and Readhead C. Rapid preimplantation detection of mutant (shiverer) and normal alleles of the mouse myelin basic protein gene allowing selective implantation and birth of live young. Proc Natl Acad Sci USA 87 (1990) 4481-4484
16. In: Hof P.R., Young W.G., Bloom F.E., Belichenko P.V., and Celio M.R. (Eds). Comparative Cytoarchitectonic Atlas of the C57BL/6 and 129/Sv Mouse Brains (2000), Elsevier Science BV, Amsterdam
17. Fraidenraich D., Stillwell E., Romero E., Wilkes D., Manova K., Basson C.T., et al. Rescue of cardiac defects in Id knockout embryos by injection of embryonic stem cells. Science 306 (2004) 247-252
18. Vermot J., Messaddeq N., Niederreither K., Dierich A., and Dolle P. Rescue of morphogenetic defects and of retinoic acid signaling in retinaldehyde dehydrogenase 2 (Raldh2) mouse mutants by chimerism with wild-type cells. Differentiation 74 (2006) 661-668
19. Popko B., Puckett C., Lai E., Shine H.D., Readhead C., Takahashi N., et al. Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin. Cell 48 (1987) 713-721
20. Shine H.D., Readhead C., Popko B., Hood L., and Sidman R.L. Morphometric analysis of normal, mutant, and transgenic CNS: correlation of myelin basic protein expression to myelinogenesis. J Neurochem 58 (1992) 342-349
21. Rosenbluth J. Axoglial junctions in the mouse mutant shiverer. Brain Res 208 (1981) 283-297
22. Wang H., Allen M.L., Grigg J.J., Noebels J.L., and Tempel B.L. Hypomyelination alters K+ channel expression in mouse mutants shiverer and trembler. Neuron 15 (1995) 1337-1347
23. Rasband M.N., Peles E., Trimmer J.S., Levinson S.R., Lux S.E., and Shrager P. Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. J Neurosci 19 (1999) 7516-7528
24. Brady S.T., Witt A.S., Kirkpatrick L.L., de Waegh S.M., Readhead C., Tu P.H., et al. Formation of compact myelin is required for maturation of the axonal cytoskeleton. J Neurosci 19 (1999) 7278-7288