Epidermal growth factor receptor pathway gene expressions and biological response of glioblastoma multiforme cell lines to erlotinib

Anticancer Research

Volumn 28, Issue 6 A, 2008, Pages 3725-3728

  Halatsch, Marc E ^a   Löw, Sarah ^a   Hielscher, Thomas ^b   Schmidt, Ursula ^b   Unterberg, Andreas ^a   Vougioukas, Vassilios I ^c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

cRNA microarrays; Epidermal growth factor receptor pathway; Erlotinib; Gene expression; Glioblastoma multiforme

Indexed keywords

COMPLEMENTARY RNA; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 13; MYC PROTEIN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E RECEPTOR 4; RAC1 PROTEIN; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA MICROARRAY; DRUG RESPONSE; DRUG SENSITIVITY; FK506 BINDING PROTEIN 14 GENE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; GENETIC TRANSDUCTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MYELOCYTOMATOSIS VIRAL ONCOGENE HOMOLOG GENE; ONCOGENE MYC; PHARMACOGENETICS; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTAGLANDIN E RECEPTOR 4 GENE; QUANTITATIVE ANALYSIS; RAS RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 GENE; RNA HYBRIDIZATION; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 GENE;

CELL LINE, TUMOR; GENE EXPRESSION; GENES, ERBB-1; GENES, MYC; GLIOBLASTOMA; HUMANS; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RAC1 GTP-BINDING PROTEIN; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, PROSTAGLANDIN E; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TACROLIMUS BINDING PROTEINS;

EID: 58149145875     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Halatsch M-E, Schmidt U, Bötefür IC et al: Marked inhibition of glioblastoma target cell tumorigenicity in vitro by retrovirus-mediated transfer of a hairpin ribozyme against deletion-mutant epidermal growth factor receptor messenger RNA. J Neurosurg 92: 297-305, 2000.
2. Halatsch M-E, Schmidt U, Behnke-Mursch J et al: Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours. Cancer Treat Rev 32: 74-89, 2006.
3. Halatsch M-E, Gehrke E, Vougioukas VI et al: Inverse correlation of epidermal growth factor receptor (EGFR) mRNA induction and suppression of anchorage-independent growth by OSI-774, an EGFR tyrosine kinase inhibitor, in glioblastoma multiforme cell lines. J Neurosurg 100: 523-533, 2004.
4. Diez D, Alvarez R and Dopazo A: Codelink: an R package for analysis of GE healthcare gene expression bioarrays. Bioinformatics 23: 1168-1169, 2007.
5. Oda K, Matsuoka Y, Funahashi A et al: A comprehensive pathway map of epidermal growth factor receptor signaling. Mol Syst Biol 1: 2005.0010, 2005.
6. Van der Laan MJ, Dudoit S and Pollard KS: Part II. Step-down procedures for control of the family-wise error rate. Stat Appl Genet Mol Biol 3: Article 14, Epub June 14, 2004.
7. Barnett SC, Robertson L, Graham D et al: Oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells transformed with c-myc and H-ras form high-grade glioma after stereotactic injection into the rat brain. Carcinogenesis 19: 1529-1537, 1998.
8. Broaddus WC, Chen ZJ, Prabhu SS et al: Antiproliferative effect of c-myc antisense phosphorothioate oligodeoxynucleotides in malignant glioma cells. Neurosurgery 41: 908-915, 1997.
9. Senger DL, Tudan C, Guiot M-C et al: Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes. Cancer Res 62: 2131-2140, 2002.
10. Kim HS and Lee M-S: STAT1 as a key modulator of cell death. Cell Signal 19: 454-465, 2007.
11. Levy DE and Gilliland DG: Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice. Oncogene 19: 2505-2510, 2000.
12. Kleivi K, Lind GE, Diep CB et al: Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses. Mol Cancer 6: 2, 2007.
13. Khatua S, Peterson KM, Brown KM et al: Overexpression of the EGFR/FKBP12/HIF-2α pathway identified in childhood astrocytomas by angiogenesis profiling. Cancer Res 63: 1865-1870, 2003.