Practical asymmetric synthesis of trifluoromethyl-containing aminoester using a modified davis protocol

Organic Process Research and Development

Volumn 12, Issue 3, 2008, Pages 424-428

  Alirnardanov, Asaf ^a   Schmid, Jean ^a   Afragola, Jay ^a   Khafizova, Gulnaz ^a  

^a WYETH RESEARCH   (United States)

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EID: 58149145253     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op700259d     Document Type: Article

References (26)

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3. Estimated 80% ee.
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26. Ester 1 was converted to several pharmacologically active derivatives of interest in two steps. Enantiomeric purity was determined for one of the derivatives purified by recrystallization and was found to be >99% ee by chiral HPLC.