Designing sleeping sickness control

ACS Chemical Biology

Volumn 3, Issue 10, 2008, Pages 601-603

  Kinoshita, Taroh ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; MANNOSE; MANNOSYLTRANSFERASE; N ACETYLGLUCOSAMINE; PALMITIC ACID; PHOSPHATIDYLINOSITOL; PHOSPHOETHANOLAMINE; TRANSFERRIN RECEPTOR; TRYPANOSOMA VACCINE; VARIANT SURFACE GLYCOPROTEIN;

ACETYLATION; AFRICAN TRYPANOSOMIASIS; ANTIBODY RESPONSE; DRUG TARGETING; HUMAN; INFECTION CONTROL; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN TARGETING; SHORT SURVEY; TRYPANOSOMA BRUCEI; TSETSE FLY;

ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; GLYCOSYLPHOSPHATIDYLINOSITOLS; MANNOSYLTRANSFERASES; RECEPTORS, TRANSFERRIN; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN; VARIANT SURFACE GLYCOPROTEINS, TRYPANOSOMA;

PROTOZOA; TRYPANOSOMA BRUCEI;

EID: 58149142624     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb800239p     Document Type: Short Survey

References (12)

1. World Health Organization (2001) African trypanosomiasis or sleeping sickness, Fact Sheet N-259, WHO Publications, Geneva.
2. Urbaniak, M. D., Yashunsky, D. V., Crossman, A., Nikolaev, A. V., and Ferguson, M. A. (2008) Probing enzymes late in the trypanosomal glycosylphosphatidylinositol biosynthetic pathway with synthetic glycosylphosphatidylinositol analogues, ACS Chem. Biol. 10, 625-634.
3. Cross, G. A. (1996) Antigenic variation in trypanosomes: secrets surface slowly, Bioessays 18, 283-291.
4. Frearson, J. A., Wyatt, P. G., Gilbert, I. H., and Fairlamb, A. H. (2007) Target assessment for antiparasitic drug discovery, Trends Parasitol. 23, 589-595.
5. Ferguson, M. A., Brimacombe, J. S., Brown, J. R., Crossman, A., Dix, A., Field, R. A., Guther, M. L., Milne, K. G., Sharma, D. K., and Smith, T. K. (1999) The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness, Biochim. Biophys. Acta 1455, 327-340.
6. Orlean, P., and Menon, A. K. (2007) Thematic review series: lipid posttranslational modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids, J. Lipid Res. 48, 993-1011.
7. Nagamune, K., Nozaki, T., Maeda, Y., Ohishi, K., Fukuma, T., Hara, T., Schwarz, R. T., Sutterlin, C., Brun, R., Riezman, H., and Kinoshita, T. (2000) Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei, Proc. Natl. Acad. Sci. U.S.A. 97, 10336-10341.
8. Chang, T., Milne, K. G., Guther, M. L., Smith, T. K., and Ferguson, M. A. (2002) Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite, J. Biol. Chem. 277, 50176-50182.
9. Ferguson, M. A. J. (2000) Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness, Proc. Natl. Acad. Sci. U.S.A. 97, 10673-10675.
10. Smith, T. K., Sharma, D. K., Crossman, A., Brimacombe, J. S., and Ferguson, M. A. (1999) Selective inhibitors of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei, EMBO J. 18, 5922-5930.
11. Smith, T. K., Crossman, A., Borissow, C. N., Paterson, M. J., Dix, A., Brimacombe, J. S., and Ferguson, M. A. (2001) Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors, EMBO J. 20, 3322-3332.
12. Smith, T. K., Crossman, A., Brimacombe, J. S., and Ferguson, M. A. (2004) Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness, EMBO J. 23, 4701-4708.