A "Glyconutrient Sham"

Glycobiology

Volumn 18, Issue 9, 2008, Pages 652-657

  Schnaar, Ronald I ^a,b   Freeze, Hudson H ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

Aloe glucomannan; Ambrotose ; Larch arabinogalactan; Mannatech; Nutraceutical; Texas attorney general

Indexed keywords

AMBROTOSE; ARABINOGALACTAN; EMODIN; GLYCONUTRIENT; MANNAN; NUTRACEUTICAL; PLANT EXTRACT; PLANT GLYCOSIDE; PLANT GUM; UNCLASSIFIED DRUG; OLIGOSACCHARIDE; PLACEBO;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BURN; CHEMICAL COMPOSITION; CLINICAL RESEARCH; CLINICAL TRIAL; DIET SUPPLEMENTATION; DIETARY FIBER; DIETARY INTAKE; DRUG APPROVAL; DRUG EFFICACY; DRUG FORMULATION; DRUG INDUSTRY; DRUG LEGISLATION; DRUG MARKETING; DRUG MECHANISM; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; ECONOMIC EVALUATION; FOOD AND DRUG ADMINISTRATION; GLYCOBIOLOGY; HUMAN; IMMUNOMODULATION; PATENT; PRIORITY JOURNAL; PRODUCT DEVELOPMENT; SKIN DISEASE; FOOD; LAWYER; LEGAL ASPECT; MEDICAL RESEARCH; MEDICOLEGAL ASPECT; PERCEPTION; TREATMENT OUTCOME;

ALOE; LARIX;

BIOMEDICAL RESEARCH; CLINICAL TRIALS AS TOPIC; DIETARY SUPPLEMENTS; DRUG INDUSTRY; FOOD; HUMANS; LAWYERS; LEGISLATION, MEDICAL; OLIGOSACCHARIDES; PERCEPTION; PLACEBOS; TREATMENT OUTCOME;

EID: 58149109874     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwm098     Document Type: Article

References (23)

1. Axford JS. 2005. 7th Jenner Glycobiology and Medicine Symposium. Adv Exp Med Biol. 564:v-viii.
2. Brammer R. 2005. Manna from Texas. Barron's Online: May 9, 2005.
3. Currier NL, Lejtenyi D, Miller SC. 2003. Effect over time of in-vivo administration of the polysaccharide arabinogalactan on immune and hemopoietic cell lineages in murine spleen and bone marrow. Phytomedicine. 10:145-153.
4. Eastwood MA, Brydon WG, Anderson DM. 1984. The effects of dietary gum tragacanth in man. Toxicol Lett. 21:73-81.
5. Hauer J, Anderer FA. 1993. Mechanism of stimulation of human natural killer cytotoxicity by arabinogalactan from Larix occidentalis. Cancer Immunol Immunother. 36:237-244.
6. Kaiser J. 2007. Science and commerce. Who owns glycobiology? Science 318:734-737.
7. Kim LS, Waters RF, Burkholder PM. 2002. Immunological activity of larch arabinogalactan and Echinacea: A preliminary, randomized, double-blind, placebo-controlled trial. Altern Med Rev. 7:138-149.
8. Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C. 2007. The efficacy of aloe vera used for burn wound healing: A systematic review. Burns. 33:713-718.
9. Marett R, Slavin JL. 2004. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc. 104:636-639.
10. Montaner JS, Gill J, Singer J, Raboud J, Arseneau R, McLean BD, Schechter MT, Ruedy J. 1996. Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease. J Acquir Immune Defic Syndr Hum Retrovirol. 12:153-157.
11. Murray RK, Granner DK, Rodwell VW. 2006. Harper's Illustrated Biochemistry, 27th ed. Columbus (OH): McGraw-Hill.
12. Niehues R, Hasilik M, Alton G, Korner C, Schiebe-Sukumar M, Koch HG, Zimmer KP, Wu R, Harms E, Reiter K, et al. 1998. Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy. J Clin Invest. 101:1414-1420.
13. Ponder GR, Richards GN. 1997. Arabinogalactan from Western larch: Part III. Alkaline degradation revisited, with novel conclusions on molecular structure. Carbohydr Polym. 34:251-261.
14. Pugh N, Ross SA, ElSohly MA, Pasco DS. 2001. Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J Agric Food Chem. 49:1030-1034.
15. Robbins D. 2006. Charity's links to firm raise questions. http://www.startelegram.com/consumer_news/story/105587.html.
16. Robb-Nicholson C. 2007. By the way, doctor. Should I supplement my diet with Ambrotose? Harv Women's Health Watch.14:8.
17. Robinson RR, Feirtag J, Slavin JL. 2001. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr. 20:279-285.
18. Sierpina VS, Murray RK. 2006. Glyconutrients: The state of the science and the impact of glycomics. Explore (NY). 2:488-494.
19. Tai-Nin CJ, Williamson DA, Yates KM, Goux WJ. 2005. Chemical characterization of the immunomodulating polysaccharide of Aloe vera L. Carbohydr Res. 340:1131-1142.
20. Tischer CA, Iacomini M, Gorin PA. 2002. Structure of the arabinogalactan from gum tragacanth (Astralagus gummifer). Carbohydr Res. 337:1647-1655.
21. Tischer CA, Iacomini M, Wagner R, Gorin PA. 2002. New structural features of the polysaccharide from gum ghatti (Anogeissus latifola). Carbohydr Res. 337:2205-2210.
22. Verbeken D, Dierckx S, Dewettinck K. 2003. Exudate gums: Occurrence, production, and applications. Appl Microbiol Biotechnol. 63:10-21.
23. Werz DB, Ranzinger R, Herget S, Adibekian A, von der Lieth C-W, Seeberger PH. 2007. Exploring the structural diversity of mammalian carbohydrates ("Glycospace") by statistical databank analysis. ACS Chem Biol. 2:685-691.